| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FRANKLIN RESOURCES INC | 7,685,568 | 100,669,000 | 14.02% | ||
| 2 | TANG CAPITAL MANAGEMENT LLC | 6,197,198 | 81,183,000 | 11.31% | ||
| 3 | FMR LLC | 5,872,839 | 76,934,000 | 10.72% | ||
| 4 | JANUS HENDERSON INVESTORS US LLC | 4,575,807 | 59,947,000 | 8.35% | ||
| 5 | Broadfin Capital, LLC | 3,899,587 | 51,085,000 | 7.12% | ||
| 6 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 2,813,161 | 36,852,000 | 5.13% | ||
| 7 | PFM Health Sciences, LP | 2,733,277 | 35,806,000 | 4.99% | ||
| 8 | BAKER BROS. ADVISORS LP | 2,383,569 | 31,225,000 | 4.35% | ||
| 9 | Cormorant Asset Management, LP | 1,951,263 | 25,562,000 | 3.56% | ||
| 10 | HIGHLAND CAPITAL MANAGEMENT LP | 1,562,817 | 20,473,000 | 2.85% | ||
| 11 | STATE STREET CORP | 1,367,565 | 17,913,000 | 2.50% | ||
| 12 | VANGUARD GROUP INC | 1,337,540 | 17,522,000 | 2.44% | ||
| 13 | VHCP Management, LLC | 1,095,734 | 14,354,000 | 2.00% | ||
| 14 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,035,000 | 13,559,000 | 1.89% | Call | |
| 15 | BlackRock Fund Advisors | 1,019,962 | 13,362,000 | 1.86% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 831,324 | 10,890,000 | 1.52% | ||
| 17 | Invesco Ltd. | 585,819 | 7,674,000 | 1.07% | ||
| 18 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 566,900 | 7,426,000 | 1.03% | Put | |
| 19 | RUBRIC CAPITAL MANAGEMENT LP | 550,000 | 7,205,000 | 1.00% | ||
| 20 | Alyeska Investment Group, L.P. | 523,597 | 6,859,000 | 0.96% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 485,927 | 6,366,000 | 0.89% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 480,700 | 6,297,000 | 0.88% | Call | |
| 23 | ROYAL BANK OF CANADA | 412,461 | 5,402,000 | 0.75% | ||
| 24 | VHCP MANAGEMENT II, LLC | 405,901 | 5,317,000 | 0.74% | ||
| 25 | NORTHERN TRUST CORP | 366,685 | 4,803,000 | 0.67% | ||
| 26 | PANAGORA ASSET MANAGEMENT INC | 273,973 | 3,589,000 | 0.50% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 264,556 | 3,465,000 | 0.48% | ||
| 28 | MILLENNIUM MANAGEMENT LLC | 257,062 | 3,368,000 | 0.47% | ||
| 29 | DEUTSCHE BANK AG\ | 255,534 | 3,345,000 | 0.47% | ||
| 30 | EVENTIDE ASSET MANAGEMENT, LLC | 225,000 | 2,948,000 | 0.41% | ||
| 31 | CITIGROUP INC | 214,583 | 2,810,000 | 0.39% | ||
| 32 | CITADEL ADVISORS LLC | 176,733 | 2,315,000 | 0.32% | ||
| 33 | MORGAN STANLEY | 156,873 | 2,054,000 | 0.29% | ||
| 34 | HAP Trading, LLC | 154,035 | 2,018,000 | 0.28% | ||
| 35 | Bank of New York Mellon Corp | 150,114 | 1,967,000 | 0.27% | ||
| 36 | BlackRock Investment Management, LLC | 123,064 | 1,612,000 | 0.22% | ||
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 120,318 | 1,577,000 | 0.22% | ||
| 38 | GUGGENHEIM CAPITAL LLC | 102,069 | 1,337,000 | 0.19% | ||
| 39 | Lombard Odier Asset Management (USA) Corp | 100,000 | 1,310,000 | 0.18% | ||
| 40 | Allianz Asset Management GmbH | 93,528 | 1,225,000 | 0.17% | ||
| 41 | TIAA CREF INVESTMENT MANAGEMENT LLC | 91,303 | 1,196,000 | 0.17% | ||
| 42 | JPMORGAN CHASE & CO | 67,455 | 884,000 | 0.12% | ||
| 43 | ALDEN GLOBAL CAPITAL LLC | 65,935 | 864,000 | 0.12% | ||
| 44 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 65,532 | 858,000 | 0.12% | ||
| 45 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 62,300 | 816,000 | 0.11% | ||
| 46 | GAM Holding AG | 59,100 | 774,000 | 0.11% | ||
| 47 | TEACHERS ADVISORS, LLC | 57,858 | 758,000 | 0.11% | ||
| 48 | CUTLER GROUP LLC / CA | 56,482 | 739,000 | 0.10% | ||
| 49 | Swiss National Bank | 51,900 | 680,000 | 0.09% | ||
| 50 | BANK OF AMERICA CORP /DE/ | 51,495 | 675,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
