| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FRANKLIN RESOURCES INC | 7,735,848 | 133,283,000 | 14.78% | ||
| 2 | TANG CAPITAL MANAGEMENT LLC | 6,197,198 | 106,778,000 | 11.84% | ||
| 3 | FMR LLC | 5,852,294 | 100,835,000 | 11.18% | ||
| 4 | JANUS HENDERSON INVESTORS US LLC | 4,033,800 | 69,502,000 | 7.71% | ||
| 5 | PFM Health Sciences, LP | 3,390,252 | 58,414,000 | 6.48% | ||
| 6 | BAKER BROS. ADVISORS LP | 2,857,250 | 49,230,000 | 5.46% | ||
| 7 | Broadfin Capital, LLC | 2,850,000 | 49,105,000 | 5.44% | ||
| 8 | Invesco Ltd. | 2,773,656 | 47,790,000 | 5.30% | ||
| 9 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 2,695,997 | 46,452,000 | 5.15% | ||
| 10 | Cormorant Asset Management, LP | 1,771,263 | 30,519,000 | 3.38% | ||
| 11 | VANGUARD GROUP INC | 1,310,980 | 22,588,000 | 2.50% | ||
| 12 | STATE STREET CORP | 1,097,543 | 18,915,000 | 2.10% | ||
| 13 | VHCP Management, LLC | 1,095,734 | 18,879,000 | 2.09% | ||
| 14 | BlackRock Fund Advisors | 878,227 | 15,132,000 | 1.68% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 830,576 | 14,311,000 | 1.59% | ||
| 16 | HIGHLAND CAPITAL MANAGEMENT LP | 650,731 | 11,212,000 | 1.24% | ||
| 17 | ROYAL BANK OF CANADA | 417,900 | 7,200,000 | 0.80% | ||
| 18 | VHCP MANAGEMENT II, LLC | 405,901 | 6,994,000 | 0.78% | ||
| 19 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 388,600 | 6,696,000 | 0.74% | Put | |
| 20 | RTW INVESTMENTS, LP | 386,787 | 6,664,000 | 0.74% | ||
| 21 | NORTHERN TRUST CORP | 358,265 | 6,173,000 | 0.68% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 322,200 | 5,552,000 | 0.62% | Call | |
| 23 | Broadfin Capital, LLC | 300,000 | 5,169,000 | 0.57% | Call | |
| 24 | Asset Management One Co., Ltd. | 274,368 | 4,691,000 | 0.52% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 255,038 | 4,394,000 | 0.49% | ||
| 26 | PANAGORA ASSET MANAGEMENT INC | 201,657 | 3,475,000 | 0.39% | ||
| 27 | BOXER CAPITAL, LLC | 200,000 | 3,446,000 | 0.38% | ||
| 28 | Alyeska Investment Group, L.P. | 196,342 | 3,383,000 | 0.38% | ||
| 29 | Lombard Odier Asset Management (USA) Corp | 175,000 | 3,015,000 | 0.33% | ||
| 30 | Allianz Asset Management GmbH | 167,969 | 2,880,000 | 0.32% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 164,482 | 2,834,000 | 0.31% | ||
| 32 | Bank of New York Mellon Corp | 149,932 | 2,584,000 | 0.29% | ||
| 33 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 126,268 | 2,176,000 | 0.24% | ||
| 34 | BlackRock Investment Management, LLC | 123,625 | 2,130,000 | 0.24% | ||
| 35 | DEUTSCHE BANK AG\ | 98,089 | 1,688,000 | 0.19% | ||
| 36 | TIAA CREF INVESTMENT MANAGEMENT LLC | 95,772 | 1,650,000 | 0.18% | ||
| 37 | GUGGENHEIM CAPITAL LLC | 92,730 | 1,598,000 | 0.18% | ||
| 38 | MORGAN STANLEY | 84,014 | 1,448,000 | 0.16% | ||
| 39 | FRED ALGER MANAGEMENT, LLC | 81,903 | 1,411,000 | 0.16% | ||
| 40 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 67,332 | 1,160,000 | 0.13% | ||
| 41 | JPMORGAN CHASE & CO | 65,092 | 1,122,000 | 0.12% | ||
| 42 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 62,300 | 1,073,000 | 0.12% | ||
| 43 | Candriam S.C.A. | 60,000 | 1,034,000 | 0.11% | ||
| 44 | Brandywine Global Investment Management, LLC | 59,113 | 1,019,000 | 0.11% | ||
| 45 | GAM Holding AG | 59,100 | 1,018,000 | 0.11% | ||
| 46 | Partner Investment Management, L.P. | 56,258 | 969,000 | 0.11% | ||
| 47 | TEACHERS ADVISORS, LLC | 55,934 | 964,000 | 0.11% | ||
| 48 | Swiss National Bank | 51,900 | 894,000 | 0.10% | ||
| 49 | ALLIANCEBERNSTEIN L.P. | 48,700 | 839,000 | 0.09% | ||
| 50 | CREDIT SUISSE AG/ | 47,040 | 810,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
