| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FRANKLIN RESOURCES INC | 7,523,278 | 142,869,000 | 16.32% | ||
| 2 | FMR LLC | 5,429,452 | 103,105,000 | 11.78% | ||
| 3 | TANG CAPITAL MANAGEMENT LLC | 5,190,837 | 98,574,000 | 11.26% | ||
| 4 | JANUS HENDERSON INVESTORS US LLC | 3,497,755 | 66,424,000 | 7.59% | ||
| 5 | Invesco Ltd. | 3,146,208 | 59,746,000 | 6.83% | ||
| 6 | PFM Health Sciences, LP | 3,073,470 | 58,365,000 | 6.67% | ||
| 7 | BAKER BROS. ADVISORS LP | 2,907,784 | 55,219,000 | 6.31% | ||
| 8 | Cormorant Asset Management, LP | 1,750,000 | 33,233,000 | 3.80% | ||
| 9 | Broadfin Capital, LLC | 1,465,475 | 27,829,000 | 3.18% | ||
| 10 | STATE STREET CORP | 1,208,572 | 22,947,000 | 2.62% | ||
| 11 | VANGUARD GROUP INC | 1,157,304 | 21,978,000 | 2.51% | ||
| 12 | VHCP Management, LLC | 1,095,734 | 20,808,000 | 2.38% | ||
| 13 | BlackRock Fund Advisors | 757,175 | 14,379,000 | 1.64% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 714,241 | 13,563,000 | 1.55% | ||
| 15 | Allianz Asset Management GmbH | 472,678 | 8,976,000 | 1.03% | ||
| 16 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 433,084 | 8,224,000 | 0.94% | ||
| 17 | VHCP MANAGEMENT II, LLC | 405,901 | 7,708,000 | 0.88% | ||
| 18 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 376,700 | 7,154,000 | 0.82% | Call | |
| 19 | JPMORGAN CHASE & CO | 348,685 | 6,622,000 | 0.76% | ||
| 20 | NORTHERN TRUST CORP | 341,584 | 6,487,000 | 0.74% | ||
| 21 | BROWN ADVISORY INC | 296,356 | 5,628,000 | 0.64% | ||
| 22 | Asset Management One Co., Ltd. | 278,864 | 5,401,000 | 0.62% | ||
| 23 | PANAGORA ASSET MANAGEMENT INC | 245,392 | 4,660,000 | 0.53% | ||
| 24 | Tekla Capital Management LLC | 219,000 | 4,159,000 | 0.48% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 207,789 | 3,945,000 | 0.45% | ||
| 26 | MILLENNIUM MANAGEMENT LLC | 200,000 | 3,798,000 | 0.43% | Put | |
| 27 | FRED ALGER MANAGEMENT, LLC | 171,233 | 3,252,000 | 0.37% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 169,894 | 3,226,000 | 0.37% | ||
| 29 | GOLDMAN SACHS GROUP INC | 154,671 | 2,937,000 | 0.34% | ||
| 30 | Bank of New York Mellon Corp | 143,407 | 2,723,000 | 0.31% | ||
| 31 | UBS Group AG | 139,623 | 2,651,000 | 0.30% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 121,300 | 2,303,000 | 0.26% | Call | |
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 116,900 | 2,220,000 | 0.25% | Put | |
| 34 | GUGGENHEIM CAPITAL LLC | 104,617 | 1,987,000 | 0.23% | ||
| 35 | BlackRock Investment Management, LLC | 104,630 | 1,987,000 | 0.23% | ||
| 36 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 102,996 | 1,956,000 | 0.22% | ||
| 37 | SPHERA FUNDS MANAGEMENT LTD. | 100,000 | 1,899,000 | 0.22% | ||
| 38 | TURNER INVESTMENTS LLC | 96,570 | 1,834,000 | 0.21% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 88,990 | 1,690,000 | 0.19% | ||
| 40 | Brandywine Global Investment Management, LLC | 74,085 | 1,407,000 | 0.16% | ||
| 41 | DRIEHAUS CAPITAL MANAGEMENT LLC | 72,059 | 1,368,000 | 0.16% | ||
| 42 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 68,700 | 1,305,000 | 0.15% | ||
| 43 | Jefferies Group LLC | 68,400 | 1,299,000 | 0.15% | Call | |
| 44 | DEUTSCHE BANK AG\ | 65,939 | 1,250,000 | 0.14% | ||
| 45 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 61,900 | 1,175,000 | 0.13% | ||
| 46 | GAM Holding AG | 59,100 | 1,122,000 | 0.13% | ||
| 47 | TEACHERS ADVISORS, LLC | 58,473 | 1,110,000 | 0.13% | ||
| 48 | GOLDMAN SACHS GROUP INC | 57,000 | 1,082,000 | 0.12% | Call | |
| 49 | CREDIT SUISSE AG/ | 55,020 | 1,045,000 | 0.12% | ||
| 50 | GOLDMAN SACHS GROUP INC | 50,000 | 950,000 | 0.11% | Put |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
