| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FRANKLIN RESOURCES INC | 7,752,460 | 139,937,000 | 16.19% | ||
| 2 | TANG CAPITAL MANAGEMENT LLC | 6,197,198 | 111,860,000 | 12.94% | ||
| 3 | FMR LLC | 5,493,420 | 99,156,000 | 11.47% | ||
| 4 | JANUS HENDERSON INVESTORS US LLC | 4,013,921 | 72,450,000 | 8.38% | ||
| 5 | PFM Health Sciences, LP | 3,351,104 | 60,487,000 | 7.00% | ||
| 6 | Invesco Ltd. | 2,909,591 | 52,519,000 | 6.08% | ||
| 7 | BAKER BROS. ADVISORS LP | 2,857,250 | 51,573,000 | 5.97% | ||
| 8 | Cormorant Asset Management, LP | 1,771,263 | 31,971,000 | 3.70% | ||
| 9 | Broadfin Capital, LLC | 1,250,104 | 22,564,000 | 2.61% | ||
| 10 | VANGUARD GROUP INC | 1,215,343 | 21,937,000 | 2.54% | ||
| 11 | VHCP Management, LLC | 1,095,734 | 19,778,000 | 2.29% | ||
| 12 | STATE STREET CORP | 994,232 | 17,944,000 | 2.08% | ||
| 13 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 911,107 | 16,445,000 | 1.90% | ||
| 14 | BlackRock Fund Advisors | 827,352 | 14,934,000 | 1.73% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 751,349 | 13,562,000 | 1.57% | ||
| 16 | Tekla Capital Management LLC | 492,303 | 8,886,000 | 1.03% | ||
| 17 | VHCP MANAGEMENT II, LLC | 405,901 | 7,327,000 | 0.85% | ||
| 18 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 376,700 | 6,799,000 | 0.79% | Call | |
| 19 | NORTHERN TRUST CORP | 356,979 | 6,443,000 | 0.75% | ||
| 20 | JPMORGAN CHASE & CO | 336,888 | 6,079,000 | 0.70% | ||
| 21 | BROWN ADVISORY INC | 307,827 | 5,557,000 | 0.64% | ||
| 22 | Asset Management One Co., Ltd. | 300,337 | 5,406,000 | 0.63% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 275,600 | 4,975,000 | 0.58% | Call | |
| 24 | PANAGORA ASSET MANAGEMENT INC | 261,298 | 4,716,000 | 0.55% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 218,988 | 3,952,000 | 0.46% | ||
| 26 | Allianz Asset Management GmbH | 214,891 | 3,879,000 | 0.45% | ||
| 27 | CITADEL ADVISORS LLC | 213,517 | 3,854,000 | 0.45% | ||
| 28 | UBS Group AG | 205,972 | 3,718,000 | 0.43% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 168,100 | 3,034,000 | 0.35% | Put | |
| 30 | Bank of New York Mellon Corp | 147,986 | 2,672,000 | 0.31% | ||
| 31 | DEUTSCHE BANK AG\ | 143,830 | 2,594,000 | 0.30% | ||
| 32 | BlackRock Investment Management, LLC | 123,234 | 2,224,000 | 0.26% | ||
| 33 | GAM Holding AG | 118,200 | 2,134,000 | 0.25% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 114,519 | 2,067,000 | 0.24% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 111,768 | 2,018,000 | 0.23% | ||
| 36 | FRED ALGER MANAGEMENT, LLC | 100,135 | 1,807,000 | 0.21% | ||
| 37 | GUGGENHEIM CAPITAL LLC | 98,382 | 1,776,000 | 0.21% | ||
| 38 | TURNER INVESTMENTS LLC | 96,570 | 1,743,000 | 0.20% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 96,225 | 1,737,000 | 0.20% | ||
| 40 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 66,632 | 1,203,000 | 0.14% | ||
| 41 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 66,600 | 1,202,000 | 0.14% | ||
| 42 | Brandywine Global Investment Management, LLC | 59,466 | 1,074,000 | 0.12% | ||
| 43 | D. E. Shaw & Co., Inc. | 57,850 | 1,044,000 | 0.12% | ||
| 44 | CREDIT SUISSE AG/ | 56,002 | 1,012,000 | 0.12% | ||
| 45 | TEACHERS ADVISORS, LLC | 55,934 | 1,010,000 | 0.12% | ||
| 46 | Swiss National Bank | 51,900 | 937,000 | 0.11% | ||
| 47 | Partner Investment Management, L.P. | 48,279 | 871,000 | 0.10% | ||
| 48 | ALLIANCEBERNSTEIN L.P. | 47,400 | 856,000 | 0.10% | ||
| 49 | BANK OF AMERICA CORP /DE/ | 41,134 | 742,000 | 0.09% | ||
| 50 | GROUP ONE TRADING LLC | 37,776 | 682,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
