| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | TANG CAPITAL MANAGEMENT LLC | 4,919,625 | 40,980,000 | 20.16% | ||
| 2 | FRANKLIN RESOURCES INC | 4,223,152 | 35,179,000 | 17.31% | ||
| 3 | Broadfin Capital, LLC | 2,808,173 | 23,392,000 | 11.51% | ||
| 4 | BAKER BROS. ADVISORS LP | 2,607,784 | 21,723,000 | 10.69% | ||
| 5 | VHCP Management, LLC | 1,095,734 | 9,127,000 | 4.49% | ||
| 6 | PERCEPTIVE ADVISORS LLC | 885,352 | 7,375,000 | 3.63% | ||
| 7 | Tekla Capital Management LLC | 873,940 | 7,280,000 | 3.58% | ||
| 8 | DRIEHAUS CAPITAL MANAGEMENT LLC | 859,481 | 7,159,000 | 3.52% | ||
| 9 | Cormorant Asset Management, LP | 700,000 | 5,831,000 | 2.87% | ||
| 10 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 683,315 | 5,699,000 | 2.80% | ||
| 11 | VANGUARD GROUP INC | 564,533 | 4,702,000 | 2.31% | ||
| 12 | BlackRock Fund Advisors | 541,666 | 4,512,000 | 2.22% | ||
| 13 | FEDERATED HERMES, INC. | 375,000 | 3,124,000 | 1.54% | ||
| 14 | EMERALD ADVISERS, LLC | 305,900 | 2,548,000 | 1.25% | ||
| 15 | THB ASSET MANAGEMENT | 300,120 | 2,499,000 | 1.23% | ||
| 16 | EMERALD MUTUAL FUND ADVISERS TRUST | 290,180 | 2,417,000 | 1.19% | ||
| 17 | NORTHERN TRUST CORP | 234,079 | 1,950,000 | 0.96% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 220,167 | 1,834,000 | 0.90% | ||
| 19 | STATE STREET CORP | 214,365 | 1,781,000 | 0.88% | ||
| 20 | MILLENNIUM MANAGEMENT LLC | 200,469 | 1,670,000 | 0.82% | ||
| 21 | SABBY MANAGEMENT, LLC | 185,000 | 1,541,000 | 0.76% | ||
| 22 | Forward Management, LLC | 135,748 | 1,423,000 | 0.70% | ||
| 23 | Alyeska Investment Group, L.P. | 125,669 | 1,047,000 | 0.52% | ||
| 24 | TURNER INVESTMENTS LLC | 123,730 | 1,031,000 | 0.51% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 123,467 | 1,028,000 | 0.51% | ||
| 26 | Bank of New York Mellon Corp | 107,591 | 896,000 | 0.44% | ||
| 27 | DEUTSCHE BANK AG\ | 87,426 | 726,000 | 0.36% | ||
| 28 | TIAA CREF INVESTMENT MANAGEMENT LLC | 73,170 | 610,000 | 0.30% | ||
| 29 | Ghost Tree Capital, LLC | 70,000 | 583,000 | 0.29% | ||
| 30 | Rock Springs Capital Management LP | 70,000 | 583,000 | 0.29% | ||
| 31 | BlackRock Investment Management, LLC | 65,938 | 549,000 | 0.27% | ||
| 32 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 42,804 | 357,000 | 0.18% | ||
| 33 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 40,750 | 340,000 | 0.17% | ||
| 34 | GLG Partners LP | 30,643 | 255,000 | 0.13% | ||
| 35 | TEACHERS ADVISORS, LLC | 26,021 | 217,000 | 0.11% | ||
| 36 | METROPOLITAN LIFE INSURANCE CO/NY | 22,917 | 191,000 | 0.09% | ||
| 37 | Nationwide Fund Advisors | 17,597 | 147,000 | 0.07% | ||
| 38 | VOYA INVESTMENT MANAGEMENT LLC | 17,249 | 144,000 | 0.07% | ||
| 39 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 15,846 | 132,000 | 0.06% | ||
| 40 | RHUMBLINE ADVISERS | 15,875 | 132,000 | 0.06% | ||
| 41 | Spark Investment Management LLC | 15,500 | 129,000 | 0.06% | ||
| 42 | AMERICAN INTERNATIONAL GROUP, INC. | 12,760 | 106,291 | 0.05% | ||
| 43 | Geduld E E | 10,000 | 83,000 | 0.04% | ||
| 44 | BLACKROCK ADVISORS LLC | 9,235 | 77,000 | 0.04% | ||
| 45 | BANK OF AMERICA CORP /DE/ | 5,160 | 43,000 | 0.02% | ||
| 46 | MORGAN STANLEY | 3,738 | 32,000 | 0.02% | ||
| 47 | BNP PARIBAS FINANCIAL MARKETS | 1,624 | 13,528 | 0.01% | ||
| 48 | WELLS FARGO & COMPANY/MN | 1,172 | 10,000 | 0.00% | ||
| 49 | ALLIANCEBERNSTEIN L.P. | 1,000 | 8,000 | 0.00% | ||
| 50 | GROUP ONE TRADING LLC | 900 | 8,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
