| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FRANKLIN RESOURCES INC | 5,870,270 | 156,737,000 | 12.57% | ||
| 2 | FMR LLC | 5,390,298 | 143,921,000 | 11.54% | ||
| 3 | TANG CAPITAL MANAGEMENT LLC | 5,190,837 | 138,595,000 | 11.11% | ||
| 4 | Invesco Ltd. | 3,312,385 | 88,441,000 | 7.09% | ||
| 5 | JANUS HENDERSON INVESTORS US LLC | 3,131,347 | 83,607,000 | 6.70% | ||
| 6 | BAKER BROS. ADVISORS LP | 2,907,784 | 77,638,000 | 6.23% | ||
| 7 | PFM Health Sciences, LP | 2,777,464 | 74,158,000 | 5.95% | ||
| 8 | Broadfin Capital, LLC | 2,232,001 | 59,594,000 | 4.78% | ||
| 9 | Cormorant Asset Management, LP | 1,685,719 | 45,009,000 | 3.61% | ||
| 10 | STATE STREET CORP | 1,424,311 | 38,027,000 | 3.05% | ||
| 11 | VANGUARD GROUP INC | 1,102,364 | 29,433,000 | 2.36% | ||
| 12 | VHCP Management, LLC | 1,095,734 | 29,256,000 | 2.35% | ||
| 13 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 869,029 | 23,203,000 | 1.86% | ||
| 14 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 800,000 | 21,360,000 | 1.71% | Call | |
| 15 | BlackRock Fund Advisors | 793,276 | 21,180,000 | 1.70% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 704,262 | 18,804,000 | 1.51% | ||
| 17 | ALLIANCEBERNSTEIN L.P. | 634,361 | 15,478,000 | 1.24% | ||
| 18 | Allianz Asset Management GmbH | 446,891 | 12,220,000 | 0.98% | ||
| 19 | UBS Group AG | 351,207 | 9,378,000 | 0.75% | ||
| 20 | NORTHERN TRUST CORP | 342,416 | 9,143,000 | 0.73% | ||
| 21 | CITADEL ADVISORS LLC | 328,985 | 8,784,000 | 0.70% | ||
| 22 | JPMORGAN CHASE & CO | 328,948 | 8,783,000 | 0.70% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 312,900 | 8,354,000 | 0.67% | Call | |
| 24 | BROWN ADVISORY INC | 300,941 | 8,036,000 | 0.64% | ||
| 25 | Asset Management One Co., Ltd. | 250,065 | 7,336,000 | 0.59% | ||
| 26 | FRED ALGER MANAGEMENT, LLC | 244,640 | 6,532,000 | 0.52% | ||
| 27 | Tekla Capital Management LLC | 219,000 | 5,847,000 | 0.47% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 204,881 | 5,469,000 | 0.44% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 201,732 | 5,386,000 | 0.43% | ||
| 30 | DRIEHAUS CAPITAL MANAGEMENT LLC | 157,326 | 4,201,000 | 0.34% | ||
| 31 | TEACHERS ADVISORS, LLC | 153,092 | 4,088,000 | 0.33% | ||
| 32 | Bank of New York Mellon Corp | 147,473 | 3,938,000 | 0.32% | ||
| 33 | SPHERA FUNDS MANAGEMENT LTD. | 135,000 | 3,605,000 | 0.29% | ||
| 34 | PANAGORA ASSET MANAGEMENT INC | 128,931 | 3,442,000 | 0.28% | ||
| 35 | HAP Trading, LLC | 120,616 | 3,220,000 | 0.26% | ||
| 36 | BANK OF MONTREAL /CAN/ | 112,720 | 3,010,000 | 0.24% | ||
| 37 | TURNER INVESTMENTS LLC | 106,080 | 2,832,000 | 0.23% | ||
| 38 | BlackRock Investment Management, LLC | 102,695 | 2,742,000 | 0.22% | ||
| 39 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 100,892 | 2,694,000 | 0.22% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 100,155 | 2,674,000 | 0.21% | ||
| 41 | Sio Capital Management, LLC | 99,772 | 2,664,000 | 0.21% | ||
| 42 | Lombard Odier Asset Management (USA) Corp | 91,938 | 2,455,000 | 0.20% | ||
| 43 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 90,600 | 2,419,000 | 0.19% | ||
| 44 | GUGGENHEIM CAPITAL LLC | 84,220 | 2,249,000 | 0.18% | ||
| 45 | OXFORD ASSET MANAGEMENT LLP | 80,036 | 2,210,000 | 0.18% | ||
| 46 | Brandywine Global Investment Management, LLC | 80,950 | 2,162,000 | 0.17% | ||
| 47 | FT OPTIONS LLC | 71,049 | 1,897,000 | 0.15% | ||
| 48 | DEUTSCHE BANK AG\ | 69,648 | 1,858,000 | 0.15% | ||
| 49 | MOORE CAPITAL MANAGEMENT, LP | 65,000 | 1,736,000 | 0.14% | ||
| 50 | AXA S.A. | 57,660 | 1,540,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
