| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FRANKLIN RESOURCES INC | 5,005,678 | 72,833,000 | 18.32% | ||
| 2 | TANG CAPITAL MANAGEMENT LLC | 4,919,625 | 71,580,000 | 18.01% | ||
| 3 | Broadfin Capital, LLC | 2,808,173 | 40,859,000 | 10.28% | ||
| 4 | BAKER BROS. ADVISORS LP | 2,607,784 | 37,943,000 | 9.55% | ||
| 5 | Cormorant Asset Management, LP | 1,270,000 | 18,479,000 | 4.65% | ||
| 6 | VHCP Management, LLC | 1,095,734 | 15,943,000 | 4.01% | ||
| 7 | Allianz Asset Management GmbH | 954,780 | 13,892,000 | 3.50% | ||
| 8 | Tekla Capital Management LLC | 873,940 | 12,716,000 | 3.20% | ||
| 9 | MILLENNIUM MANAGEMENT LLC | 676,152 | 9,838,000 | 2.48% | ||
| 10 | VANGUARD GROUP INC | 669,311 | 9,738,000 | 2.45% | ||
| 11 | BlackRock Fund Advisors | 647,951 | 9,428,000 | 2.37% | ||
| 12 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 615,851 | 8,961,000 | 2.25% | ||
| 13 | Point72 Asset Management, L.P. | 500,000 | 7,275,000 | 1.83% | ||
| 14 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 431,200 | 6,274,000 | 1.58% | Call | |
| 15 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 400,000 | 5,820,000 | 1.46% | Call | |
| 16 | STATE STREET CORP | 297,755 | 4,335,000 | 1.09% | ||
| 17 | MORGAN STANLEY | 288,802 | 4,203,000 | 1.06% | ||
| 18 | GREAT POINT PARTNERS LLC | 270,000 | 3,929,000 | 0.99% | ||
| 19 | BlackRock Institutional Trust Company, N.A. | 269,075 | 3,915,000 | 0.98% | ||
| 20 | NORTHERN TRUST CORP | 261,833 | 3,810,000 | 0.96% | ||
| 21 | Informed Momentum Co LLC | 230,261 | 3,350,000 | 0.84% | ||
| 22 | DRIEHAUS CAPITAL MANAGEMENT LLC | 183,122 | 2,664,000 | 0.67% | ||
| 23 | Alyeska Investment Group, L.P. | 156,268 | 2,274,000 | 0.57% | ||
| 24 | HAP Trading, LLC | 151,597 | 2,206,000 | 0.56% | ||
| 25 | Bank of New York Mellon Corp | 151,179 | 2,199,000 | 0.55% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 148,780 | 2,164,000 | 0.54% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 140,401 | 2,043,000 | 0.51% | ||
| 28 | Sio Capital Management, LLC | 137,100 | 1,995,000 | 0.50% | ||
| 29 | TURNER INVESTMENTS LLC | 132,740 | 1,931,000 | 0.49% | ||
| 30 | DEUTSCHE BANK AG\ | 119,256 | 1,734,000 | 0.44% | ||
| 31 | SPHERA FUNDS MANAGEMENT LTD. | 79,900 | 1,163,000 | 0.29% | ||
| 32 | AMERIPRISE FINANCIAL INC | 76,602 | 1,115,000 | 0.28% | ||
| 33 | TIAA CREF INVESTMENT MANAGEMENT LLC | 76,381 | 1,111,000 | 0.28% | ||
| 34 | BlackRock Investment Management, LLC | 66,826 | 972,000 | 0.24% | ||
| 35 | ROYCE & ASSOCIATES LP | 59,147 | 861,000 | 0.22% | ||
| 36 | RUSSELL FRANK CO/ | 57,454 | 836,000 | 0.21% | ||
| 37 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 42,488 | 618,000 | 0.16% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 40,950 | 596,000 | 0.15% | ||
| 39 | Connor, Clark & Lunn Investment Management Ltd. | 37,200 | 541,000 | 0.14% | ||
| 40 | TEACHERS ADVISORS, LLC | 37,046 | 539,000 | 0.14% | ||
| 41 | Rock Springs Capital Management LP | 32,500 | 473,000 | 0.12% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 29,300 | 426,000 | 0.11% | Put | |
| 43 | A.R.T. Advisors, LLC | 27,635 | 402,000 | 0.10% | ||
| 44 | Airain ltd | 26,278 | 382,000 | 0.10% | ||
| 45 | RHUMBLINE ADVISERS | 21,350 | 311,000 | 0.08% | ||
| 46 | VOYA INVESTMENT MANAGEMENT LLC | 17,249 | 251,000 | 0.06% | ||
| 47 | Nationwide Fund Advisors | 16,936 | 246,000 | 0.06% | ||
| 48 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 15,697 | 228,000 | 0.06% | ||
| 49 | CITADEL ADVISORS LLC | 15,703 | 228,000 | 0.06% | ||
| 50 | DEERE & CO | 14,873 | 216,000 | 0.05% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
