| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | TANG CAPITAL MANAGEMENT LLC | 4,919,625 | 49,491,000 | 19.95% | ||
| 2 | FRANKLIN RESOURCES INC | 4,464,938 | 44,917,000 | 18.11% | ||
| 3 | Broadfin Capital, LLC | 2,808,173 | 28,250,000 | 11.39% | ||
| 4 | BAKER BROS. ADVISORS LP | 2,607,784 | 26,234,000 | 10.58% | ||
| 5 | VHCP Management, LLC | 1,095,734 | 11,023,000 | 4.44% | ||
| 6 | Tekla Capital Management LLC | 873,940 | 8,792,000 | 3.54% | ||
| 7 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 855,851 | 8,610,000 | 3.47% | ||
| 8 | DRIEHAUS CAPITAL MANAGEMENT LLC | 743,747 | 7,482,000 | 3.02% | ||
| 9 | Cormorant Asset Management, LP | 700,000 | 7,042,000 | 2.84% | ||
| 10 | PERCEPTIVE ADVISORS LLC | 666,042 | 6,700,000 | 2.70% | ||
| 11 | BlackRock Fund Advisors | 640,817 | 6,447,000 | 2.60% | ||
| 12 | VANGUARD GROUP INC | 575,807 | 5,793,000 | 2.34% | ||
| 13 | Point72 Asset Management, L.P. | 510,100 | 5,132,000 | 2.07% | ||
| 14 | THB ASSET MANAGEMENT | 296,320 | 2,980,000 | 1.20% | ||
| 15 | NORTHERN TRUST CORP | 258,683 | 2,602,000 | 1.05% | ||
| 16 | MILLENNIUM MANAGEMENT LLC | 248,357 | 2,498,000 | 1.01% | ||
| 17 | STATE STREET CORP | 229,592 | 2,309,000 | 0.93% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 217,339 | 2,186,000 | 0.88% | ||
| 19 | Alyeska Investment Group, L.P. | 171,554 | 1,726,000 | 0.70% | ||
| 20 | ROYCE & ASSOCIATES LP | 170,580 | 1,716,000 | 0.69% | ||
| 21 | SABBY MANAGEMENT, LLC | 162,900 | 1,639,000 | 0.66% | ||
| 22 | Rock Springs Capital Management LP | 160,000 | 1,610,000 | 0.65% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 125,484 | 1,262,000 | 0.51% | ||
| 24 | DEUTSCHE BANK AG\ | 111,784 | 1,123,000 | 0.45% | ||
| 25 | Bank of New York Mellon Corp | 105,561 | 1,061,000 | 0.43% | ||
| 26 | ACUTA CAPITAL PARTNERS, LLC | 101,050 | 1,017,000 | 0.41% | ||
| 27 | PACIFIC ALTERNATIVE ASSET MANAGEMENT COMPANY, LLC | 84,600 | 851,000 | 0.34% | Call | |
| 28 | TURNER INVESTMENTS LLC | 80,080 | 806,000 | 0.32% | ||
| 29 | TIAA CREF INVESTMENT MANAGEMENT LLC | 76,381 | 768,000 | 0.31% | ||
| 30 | BlackRock Investment Management, LLC | 66,338 | 667,000 | 0.27% | ||
| 31 | Avoro Capital Advisors LLC | 65,900 | 663,000 | 0.27% | ||
| 32 | Endurant Capital Management LP | 58,100 | 584,000 | 0.24% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 45,678 | 460,000 | 0.19% | ||
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 42,988 | 432,000 | 0.17% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 40,750 | 410,000 | 0.17% | ||
| 36 | TEACHERS ADVISORS, LLC | 31,593 | 318,000 | 0.13% | ||
| 37 | METROPOLITAN LIFE INSURANCE CO/NY | 22,917 | 231,000 | 0.09% | ||
| 38 | MORGAN STANLEY | 21,610 | 217,000 | 0.09% | ||
| 39 | D. E. Shaw & Co., Inc. | 19,610 | 197,000 | 0.08% | ||
| 40 | Nationwide Fund Advisors | 17,597 | 177,000 | 0.07% | ||
| 41 | JPMORGAN CHASE & CO | 17,469 | 176,000 | 0.07% | ||
| 42 | VOYA INVESTMENT MANAGEMENT LLC | 17,249 | 174,000 | 0.07% | ||
| 43 | RHUMBLINE ADVISERS | 16,450 | 165,000 | 0.07% | ||
| 44 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 16,208 | 163,000 | 0.07% | ||
| 45 | AMERICAN INTERNATIONAL GROUP, INC. | 14,646 | 147,339 | 0.06% | ||
| 46 | GROUP ONE TRADING LLC | 13,347 | 134,000 | 0.05% | ||
| 47 | CITADEL ADVISORS LLC | 13,054 | 131,000 | 0.05% | ||
| 48 | BLACKROCK ADVISORS LLC | 10,725 | 108,000 | 0.04% | ||
| 49 | PRUDENTIAL FINANCIAL INC | 10,300 | 104,000 | 0.04% | ||
| 50 | EMERALD ADVISERS, LLC | 10,350 | 104,000 | 0.04% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
