| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FRANKLIN RESOURCES INC | 6,357,294 | 198,093,000 | 16.73% | ||
| 2 | TANG CAPITAL MANAGEMENT LLC | 5,190,837 | 161,746,000 | 13.66% | ||
| 3 | BAKER BROS. ADVISORS LP | 2,807,784 | 87,491,000 | 7.39% | ||
| 4 | Broadfin Capital, LLC | 2,396,681 | 74,681,000 | 6.31% | ||
| 5 | PFM Health Sciences, LP | 1,811,166 | 56,436,000 | 4.77% | ||
| 6 | FMR LLC | 1,767,161 | 55,065,000 | 4.65% | ||
| 7 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 1,700,000 | 52,972,000 | 4.47% | Call | |
| 8 | Cormorant Asset Management, LP | 1,440,000 | 44,870,000 | 3.79% | ||
| 9 | JANUS HENDERSON INVESTORS US LLC | 1,356,074 | 42,255,000 | 3.57% | ||
| 10 | STATE STREET CORP | 1,198,577 | 37,346,000 | 3.15% | ||
| 11 | VHCP Management, LLC | 1,095,734 | 34,143,000 | 2.88% | ||
| 12 | Invesco Ltd. | 966,955 | 30,131,000 | 2.55% | ||
| 13 | VANGUARD GROUP INC | 895,326 | 27,898,000 | 2.36% | ||
| 14 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 893,019 | 27,826,000 | 2.35% | ||
| 15 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 822,417 | 25,627,000 | 2.16% | ||
| 16 | MILLENNIUM MANAGEMENT LLC | 760,146 | 23,686,000 | 2.00% | ||
| 17 | BlackRock Fund Advisors | 643,231 | 20,043,000 | 1.69% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 484,776 | 15,106,000 | 1.28% | ||
| 19 | PERCEPTIVE ADVISORS LLC | 448,000 | 13,960,000 | 1.18% | ||
| 20 | Tekla Capital Management LLC | 436,970 | 13,616,000 | 1.15% | ||
| 21 | NORTHERN TRUST CORP | 272,178 | 8,481,000 | 0.72% | ||
| 22 | Point72 Asset Management, L.P. | 251,500 | 7,837,000 | 0.66% | ||
| 23 | UBS Group AG | 241,050 | 7,511,000 | 0.63% | ||
| 24 | MORGAN STANLEY | 228,962 | 7,135,000 | 0.60% | ||
| 25 | D. E. Shaw & Co., Inc. | 228,938 | 7,134,000 | 0.60% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 226,200 | 7,048,000 | 0.60% | Call | |
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 198,050 | 6,171,000 | 0.52% | ||
| 28 | FRED ALGER MANAGEMENT, LLC | 191,150 | 5,956,000 | 0.50% | ||
| 29 | Lombard Odier Asset Management (USA) Corp | 190,000 | 5,920,000 | 0.50% | ||
| 30 | BARCLAYS PLC | 180,000 | 5,580,000 | 0.47% | Call | |
| 31 | DRIEHAUS CAPITAL MANAGEMENT LLC | 174,402 | 5,434,000 | 0.46% | ||
| 32 | DEUTSCHE BANK AG\ | 165,203 | 5,146,000 | 0.43% | ||
| 33 | Asset Management One Co., Ltd. | 166,934 | 4,918,000 | 0.42% | ||
| 34 | Avoro Capital Advisors LLC | 150,000 | 4,674,000 | 0.39% | ||
| 35 | Bank of New York Mellon Corp | 115,028 | 3,584,000 | 0.30% | ||
| 36 | AMERIPRISE FINANCIAL INC | 114,472 | 3,567,000 | 0.30% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 100,119 | 3,120,000 | 0.26% | ||
| 38 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | 89,158 | 2,778,000 | 0.23% | ||
| 39 | BlackRock Investment Management, LLC | 87,407 | 2,724,000 | 0.23% | ||
| 40 | PANAGORA ASSET MANAGEMENT INC | 74,517 | 2,322,000 | 0.20% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 60,200 | 1,876,000 | 0.16% | Put | |
| 42 | TURNER INVESTMENTS LLC | 54,730 | 1,705,000 | 0.14% | ||
| 43 | Informed Momentum Co LLC | 51,240 | 1,597,000 | 0.13% | ||
| 44 | GROUP ONE TRADING LLC | 48,590 | 1,514,000 | 0.13% | ||
| 45 | RENAISSANCE TECHNOLOGIES LLC | 48,100 | 1,499,000 | 0.13% | ||
| 46 | ALLIANCEBERNSTEIN L.P. | 47,400 | 1,477,000 | 0.12% | ||
| 47 | Jefferies Group LLC | 45,100 | 1,405,000 | 0.12% | Call | |
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 45,011 | 1,403,000 | 0.12% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 44,560 | 1,389,000 | 0.12% | ||
| 50 | TEACHERS ADVISORS, LLC | 36,495 | 1,137,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
