| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,990,187 | 63,575,000 | 10.47% | ||
| 2 | ORBIMED ADVISORS LLC | 4,736,900 | 60,348,000 | 9.94% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 3,674,838 | 46,817,000 | 7.71% | ||
| 4 | Point72 Asset Management, L.P. | 3,410,978 | 43,456,000 | 7.15% | ||
| 5 | GOLDMAN SACHS GROUP INC | 3,390,700 | 43,198,000 | 7.11% | ||
| 6 | VANGUARD GROUP INC | 2,705,287 | 34,465,000 | 5.67% | ||
| 7 | BlackRock Fund Advisors | 2,261,583 | 28,813,000 | 4.74% | ||
| 8 | STATE STREET CORP | 1,967,894 | 25,070,000 | 4.13% | ||
| 9 | WELLINGTON MANAGEMENT GROUP LLP | 1,787,776 | 22,775,000 | 3.75% | ||
| 10 | BB BIOTECH AG | 1,505,737 | 19,183,000 | 3.16% | ||
| 11 | Broadfin Capital, LLC | 1,438,484 | 18,326,000 | 3.02% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 1,374,751 | 17,514,000 | 2.88% | ||
| 13 | GREAT POINT PARTNERS LLC | 958,600 | 12,213,000 | 2.01% | ||
| 14 | HealthCor Management, L.P. | 923,600 | 11,767,000 | 1.94% | ||
| 15 | Tekla Capital Management LLC | 680,746 | 8,673,000 | 1.43% | ||
| 16 | BAKER BROS. ADVISORS LP | 624,050 | 7,950,000 | 1.31% | ||
| 17 | PRICE T ROWE ASSOCIATES INC /MD/ | 622,520 | 7,931,000 | 1.31% | ||
| 18 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 600,000 | 7,644,000 | 1.26% | ||
| 19 | NORTHERN TRUST CORP | 568,673 | 7,245,000 | 1.19% | ||
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 537,700 | 6,850,000 | 1.13% | Put | |
| 21 | BLACKROCK ADVISORS LLC | 510,519 | 6,504,000 | 1.07% | ||
| 22 | MILLENNIUM MANAGEMENT LLC | 471,054 | 6,001,000 | 0.99% | ||
| 23 | FRANKLIN RESOURCES INC | 445,500 | 5,676,000 | 0.93% | ||
| 24 | AMERIPRISE FINANCIAL INC | 425,002 | 5,415,000 | 0.89% | ||
| 25 | DIMENSIONAL FUND ADVISORS LP | 405,708 | 5,169,000 | 0.85% | ||
| 26 | DEUTSCHE BANK AG\ | 384,134 | 4,893,000 | 0.81% | ||
| 27 | D. E. Shaw & Co., Inc. | 367,063 | 4,676,000 | 0.77% | ||
| 28 | CREDIT SUISSE AG/ | 361,958 | 4,611,000 | 0.76% | ||
| 29 | NORGES BANK | 343,291 | 4,374,000 | 0.72% | ||
| 30 | I.G. INVESTMENT MANAGEMENT, LTD. | 309,451 | 3,942,000 | 0.65% | ||
| 31 | BALYASNY ASSET MANAGEMENT L.P. | 275,421 | 3,509,000 | 0.58% | ||
| 32 | Bank of New York Mellon Corp | 260,901 | 3,323,000 | 0.55% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 234,971 | 2,993,000 | 0.49% | ||
| 34 | BARCLAYS PLC | 230,531 | 2,766,000 | 0.46% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 207,137 | 2,639,000 | 0.43% | ||
| 36 | RENAISSANCE TECHNOLOGIES LLC | 198,600 | 2,530,000 | 0.42% | ||
| 37 | TIAA CREF INVESTMENT MANAGEMENT LLC | 184,565 | 2,351,000 | 0.39% | ||
| 38 | GOLDMAN SACHS GROUP INC | 180,400 | 2,298,000 | 0.38% | Put | |
| 39 | TURNER INVESTMENTS LLC | 154,430 | 1,967,000 | 0.32% | ||
| 40 | Rock Springs Capital Management LP | 152,500 | 1,943,000 | 0.32% | ||
| 41 | BlackRock Investment Management, LLC | 140,791 | 1,794,000 | 0.30% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 137,400 | 1,750,000 | 0.29% | Call | |
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 125,482 | 1,599,000 | 0.26% | ||
| 44 | ROYCE & ASSOCIATES LP | 123,400 | 1,572,000 | 0.26% | ||
| 45 | Cheyne Capital Management (UK) LLP | 120,000 | 1,528,000 | 0.25% | ||
| 46 | Invesco Ltd. | 118,539 | 1,510,000 | 0.25% | ||
| 47 | Rhenman & Partners Asset Management AB | 113,273 | 1,443,000 | 0.24% | ||
| 48 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 107,600 | 1,371,000 | 0.23% | ||
| 49 | BARCLAYS PLC | 110,400 | 1,325,000 | 0.22% | Call | |
| 50 | MORGAN STANLEY | 103,137 | 1,313,000 | 0.22% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
