| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 4,736,900 | 56,322,000 | 9.69% | ||
| 2 | FMR LLC | 4,518,612 | 53,726,000 | 9.24% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 4,444,027 | 52,839,000 | 9.09% | ||
| 4 | GOLDMAN SACHS GROUP INC | 3,669,805 | 43,634,000 | 7.50% | ||
| 5 | SAC Capital Advisors LP | 3,411,659 | 40,565,000 | 6.98% | ||
| 6 | VANGUARD GROUP INC | 2,657,999 | 31,604,000 | 5.44% | ||
| 7 | STATE STREET CORP | 2,091,949 | 24,873,000 | 4.28% | ||
| 8 | BlackRock Fund Advisors | 1,901,092 | 22,604,000 | 3.89% | ||
| 9 | WELLINGTON MANAGEMENT GROUP LLP | 1,578,150 | 18,764,000 | 3.23% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 1,361,396 | 16,187,000 | 2.78% | ||
| 11 | Broadfin Capital, LLC | 1,326,000 | 15,766,000 | 2.71% | ||
| 12 | BB BIOTECH AG | 1,300,737 | 15,466,000 | 2.66% | ||
| 13 | Consonance Capital Management LP | 1,262,012 | 15,005,000 | 2.58% | ||
| 14 | HealthCor Management, L.P. | 1,050,000 | 12,485,000 | 2.15% | ||
| 15 | AMERIPRISE FINANCIAL INC | 777,357 | 9,241,000 | 1.59% | ||
| 16 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 700,000 | 8,323,000 | 1.43% | ||
| 17 | BAKER BROS. ADVISORS LP | 624,050 | 7,420,000 | 1.28% | ||
| 18 | PRICE T ROWE ASSOCIATES INC /MD/ | 616,220 | 7,327,000 | 1.26% | ||
| 19 | DEUTSCHE BANK AG\ | 611,092 | 7,264,000 | 1.25% | ||
| 20 | NORTHERN TRUST CORP | 608,817 | 7,239,000 | 1.25% | ||
| 21 | BLACKROCK ADVISORS LLC | 515,737 | 6,132,000 | 1.05% | ||
| 22 | GREAT POINT PARTNERS LLC | 500,400 | 5,950,000 | 1.02% | ||
| 23 | RENAISSANCE TECHNOLOGIES LLC | 498,540 | 5,928,000 | 1.02% | ||
| 24 | MILLENNIUM MANAGEMENT LLC | 482,030 | 5,731,000 | 0.99% | ||
| 25 | CREDIT SUISSE AG/ | 462,157 | 5,494,000 | 0.94% | ||
| 26 | Visium Asset Management, LP | 450,000 | 5,351,000 | 0.92% | ||
| 27 | FRANKLIN RESOURCES INC | 445,500 | 5,297,000 | 0.91% | ||
| 28 | DIMENSIONAL FUND ADVISORS LP | 374,135 | 4,449,000 | 0.77% | ||
| 29 | Tekla Capital Management LLC | 349,899 | 4,160,000 | 0.72% | ||
| 30 | NORGES BANK | 343,291 | 4,082,000 | 0.70% | ||
| 31 | GOLDMAN SACHS GROUP INC | 332,100 | 3,949,000 | 0.68% | Put | |
| 32 | Bank of New York Mellon Corp | 300,839 | 3,578,000 | 0.62% | ||
| 33 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 292,725 | 3,481,000 | 0.60% | ||
| 34 | I.G. INVESTMENT MANAGEMENT, LTD. | 270,750 | 3,219,000 | 0.55% | ||
| 35 | GEODE CAPITAL MANAGEMENT, LLC | 226,159 | 2,689,000 | 0.46% | ||
| 36 | BARCLAYS PLC | 223,871 | 2,464,000 | 0.42% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 201,800 | 2,399,000 | 0.41% | Put | |
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 185,558 | 2,206,000 | 0.38% | ||
| 39 | JPMORGAN CHASE & CO | 177,848 | 2,115,000 | 0.36% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 176,233 | 2,096,000 | 0.36% | ||
| 41 | D. E. Shaw & Co., Inc. | 166,339 | 1,977,000 | 0.34% | ||
| 42 | BlackRock Investment Management, LLC | 132,780 | 1,579,000 | 0.27% | ||
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 126,266 | 1,502,000 | 0.26% | ||
| 44 | Invesco Ltd. | 121,065 | 1,440,000 | 0.25% | ||
| 45 | Cheyne Capital Management (UK) LLP | 120,000 | 1,427,000 | 0.25% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 113,400 | 1,348,000 | 0.23% | Call | |
| 47 | BARCLAYS PLC | 110,400 | 1,214,000 | 0.21% | Call | |
| 48 | Rock Springs Capital Management LP | 97,500 | 1,159,000 | 0.20% | ||
| 49 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 107,600 | 1,135,000 | 0.20% | ||
| 50 | Rhenman & Partners Asset Management AB | 132,766 | 1,094,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
