| 1 |
BVF INC/IL |
7,860,808 |
10,612,000 |
20.78% |
|
|
| 2 |
WELLINGTON MANAGEMENT GROUP LLP |
4,358,071 |
5,883,000 |
11.52% |
|
|
| 3 |
VANGUARD GROUP INC |
3,680,641 |
4,969,000 |
9.73% |
|
|
| 4 |
ORBIMED ADVISORS LLC |
3,250,300 |
4,388,000 |
8.59% |
|
|
| 5 |
RENAISSANCE TECHNOLOGIES LLC |
1,700,000 |
2,295,000 |
4.50% |
|
|
| 6 |
BlackRock Fund Advisors |
1,644,813 |
2,220,000 |
4.35% |
|
|
| 7 |
BlackRock Institutional Trust Company, N.A. |
1,386,687 |
1,872,000 |
3.67% |
|
|
| 8 |
FMR LLC |
1,188,976 |
1,605,000 |
3.14% |
|
|
| 9 |
STATE STREET CORP |
989,060 |
1,335,000 |
2.61% |
|
|
| 10 |
MILLENNIUM MANAGEMENT LLC |
822,236 |
1,110,000 |
2.17% |
|
|
| 11 |
Numeric Investors LLC |
779,899 |
1,053,000 |
2.06% |
|
|
| 12 |
NORTHERN TRUST CORP |
766,282 |
1,035,000 |
2.03% |
|
|
| 13 |
Connor, Clark & Lunn Investment Management Ltd. |
717,075 |
968,000 |
1.90% |
|
|
| 14 |
BAKER BROS. ADVISORS LP |
580,400 |
784,000 |
1.54% |
|
|
| 15 |
PLATINUM INVESTMENT MANAGEMENT LTD |
498,232 |
672,000 |
1.32% |
|
|
| 16 |
DEUTSCHE BANK AG\ |
483,875 |
652,000 |
1.28% |
|
|
| 17 |
Parallax Volatility Advisers, L.P. |
437,500 |
591,000 |
1.16% |
Put |
|
| 18 |
OXFORD ASSET MANAGEMENT LLP |
343,172 |
463,000 |
0.91% |
|
|
| 19 |
GEODE CAPITAL MANAGEMENT, LLC |
330,361 |
445,000 |
0.87% |
|
|
| 20 |
D. E. Shaw & Co., Inc. |
306,529 |
414,000 |
0.81% |
|
|
| 21 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
293,800 |
397,000 |
0.78% |
|
|
| 22 |
PRICE T ROWE ASSOCIATES INC /MD/ |
283,595 |
383,000 |
0.75% |
|
|
| 23 |
BOGLE INVESTMENT MANAGEMENT L P /DE/ |
270,749 |
365,000 |
0.71% |
|
|
| 24 |
Rock Springs Capital Management LP |
270,000 |
365,000 |
0.71% |
|
|
| 25 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
265,558 |
359,000 |
0.70% |
|
|
| 26 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
252,771 |
341,000 |
0.67% |
|
|
| 27 |
JPMORGAN CHASE & CO |
229,145 |
309,000 |
0.61% |
|
|
| 28 |
GOLDMAN SACHS GROUP INC |
213,602 |
288,000 |
0.56% |
|
|
| 29 |
Quantitative Investment Management, LLC |
205,700 |
277,000 |
0.54% |
|
|
| 30 |
BlackRock Investment Management, LLC |
185,871 |
251,000 |
0.49% |
|
|
| 31 |
QS Investors, LLC |
182,380 |
246,000 |
0.48% |
|
|
| 32 |
MORGAN STANLEY |
182,155 |
245,000 |
0.48% |
|
|
| 33 |
Bank of New York Mellon Corp |
170,206 |
230,000 |
0.45% |
|
|
| 34 |
TUDOR INVESTMENT CORP ET AL |
165,998 |
224,000 |
0.44% |
|
|
| 35 |
ALLIANCEBERNSTEIN L.P. |
111,300 |
150,000 |
0.29% |
|
|
| 36 |
BLACKROCK ADVISORS LLC |
108,367 |
146,000 |
0.29% |
|
|
| 37 |
Evercore Wealth Management, LLC |
107,091 |
145,000 |
0.28% |
|
|
| 38 |
TEACHERS ADVISORS, LLC |
105,961 |
143,000 |
0.28% |
|
|
| 39 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
105,000 |
142,000 |
0.28% |
Put |
|
| 40 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
101,077 |
136,000 |
0.27% |
|
|
| 41 |
Nine Chapters Capital Management LLC |
96,600 |
130,000 |
0.25% |
|
|
| 42 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
93,061 |
126,000 |
0.25% |
|
|
| 43 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
91,900 |
124,000 |
0.24% |
|
|
| 44 |
BANK OF AMERICA CORP /DE/ |
86,306 |
116,000 |
0.23% |
|
|
| 45 |
BlackRock Finance, Inc. |
80,657 |
108,000 |
0.21% |
|
|
| 46 |
Candriam S.C.A. |
80,000 |
108,000 |
0.21% |
|
|
| 47 |
ACADIAN ASSET MANAGEMENT LLC |
74,175 |
101,000 |
0.20% |
|
|
| 48 |
Parallax Volatility Advisers, L.P. |
73,249 |
99,000 |
0.19% |
|
|
| 49 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
67,500 |
92,000 |
0.18% |
|
|
| 50 |
BESSEMER GROUP INC |
61,888 |
84,000 |
0.16% |
|
|
