| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | VANGUARD GROUP INC | 6,704,643 | 35,333,000 | 14.91% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 4,398,862 | 23,182,000 | 9.79% | ||
| 3 | ORBIMED ADVISORS LLC | 3,723,528 | 19,623,000 | 8.28% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 2,757,662 | 14,532,000 | 6.13% | ||
| 5 | BlackRock Fund Advisors | 2,723,919 | 14,355,000 | 6.06% | ||
| 6 | BB BIOTECH AG | 2,700,737 | 14,233,000 | 6.01% | ||
| 7 | FMR LLC | 2,365,825 | 12,468,000 | 5.26% | ||
| 8 | AMERIPRISE FINANCIAL INC | 1,686,626 | 8,891,000 | 3.75% | ||
| 9 | GOLDMAN SACHS GROUP INC | 1,633,245 | 8,607,000 | 3.63% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 1,227,205 | 6,467,000 | 2.73% | ||
| 11 | STATE STREET CORP | 867,627 | 4,569,000 | 1.93% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 800,361 | 4,218,000 | 1.78% | ||
| 13 | OXFORD ASSET MANAGEMENT LLP | 776,236 | 4,091,000 | 1.73% | ||
| 14 | TEACHERS ADVISORS, LLC | 690,931 | 3,641,000 | 1.54% | ||
| 15 | Connor, Clark & Lunn Investment Management Ltd. | 631,275 | 3,327,000 | 1.40% | ||
| 16 | NORTHERN TRUST CORP | 600,475 | 3,165,000 | 1.34% | ||
| 17 | BLACKROCK ADVISORS LLC | 504,780 | 2,660,000 | 1.12% | ||
| 18 | NORGES BANK | 500,092 | 2,636,000 | 1.11% | ||
| 19 | JPMORGAN CHASE & CO | 492,050 | 2,593,000 | 1.09% | ||
| 20 | TANG CAPITAL MANAGEMENT LLC | 460,000 | 2,424,000 | 1.02% | ||
| 21 | TFS CAPITAL LLC | 399,320 | 2,104,000 | 0.89% | ||
| 22 | PRICE T ROWE ASSOCIATES INC /MD/ | 392,860 | 2,070,000 | 0.87% | ||
| 23 | DEUTSCHE BANK AG\ | 378,769 | 1,994,000 | 0.84% | ||
| 24 | D. E. Shaw & Co., Inc. | 372,456 | 1,963,000 | 0.83% | ||
| 25 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 351,789 | 1,853,000 | 0.78% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 336,935 | 1,774,000 | 0.75% | ||
| 27 | ACADIAN ASSET MANAGEMENT LLC | 311,639 | 1,643,000 | 0.69% | ||
| 28 | CREDIT SUISSE AG/ | 293,447 | 1,546,000 | 0.65% | ||
| 29 | Rock Springs Capital Management LP | 270,000 | 1,423,000 | 0.60% | ||
| 30 | BLAIR WILLIAM & CO/IL | 253,540 | 1,336,000 | 0.56% | ||
| 31 | EVENTIDE ASSET MANAGEMENT, LLC | 246,700 | 1,300,000 | 0.55% | ||
| 32 | Bank of New York Mellon Corp | 244,143 | 1,287,000 | 0.54% | ||
| 33 | ROTHSCHILD & CO ASSET MANAGEMENT US INC. | 224,020 | 1,181,000 | 0.50% | ||
| 34 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 218,123 | 1,150,000 | 0.49% | ||
| 35 | Candriam S.C.A. | 209,000 | 1,095,000 | 0.46% | ||
| 36 | PLATINUM INVESTMENT MANAGEMENT LTD | 206,932 | 1,090,000 | 0.46% | ||
| 37 | QS Investors, LLC | 182,380 | 961,000 | 0.41% | ||
| 38 | BlackRock Investment Management, LLC | 175,980 | 927,000 | 0.39% | ||
| 39 | BELLEVUE GROUP AG | 160,000 | 843,000 | 0.36% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 155,864 | 821,000 | 0.35% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 152,493 | 804,000 | 0.34% | ||
| 42 | NEXTHERA CAPITAL LP | 145,000 | 764,000 | 0.32% | ||
| 43 | VIRGINIA RETIREMENT SYSTEM | 144,000 | 759,000 | 0.32% | ||
| 44 | Jefferies Group LLC | 130,000 | 685,000 | 0.29% | Call | |
| 45 | PANAGORA ASSET MANAGEMENT INC | 128,672 | 678,000 | 0.29% | ||
| 46 | Numeric Investors LLC | 105,554 | 556,000 | 0.23% | ||
| 47 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 103,877 | 547,000 | 0.23% | ||
| 48 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 101,400 | 534,000 | 0.23% | ||
| 49 | PERCEPTIVE ADVISORS LLC | 100,000 | 527,000 | 0.22% | ||
| 50 | Evercore Wealth Management, LLC | 93,934 | 495,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
