| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | GOLDMAN SACHS GROUP INC | 5,593,175 | 61,245,000 | 11.00% | ||
| 2 | VANGUARD GROUP INC | 5,456,663 | 59,751,000 | 10.74% | ||
| 3 | ORBIMED ADVISORS LLC | 4,416,300 | 48,358,000 | 8.69% | ||
| 4 | STATE STREET CORP | 3,255,703 | 35,647,000 | 6.41% | ||
| 5 | BlackRock Fund Advisors | 2,812,412 | 30,796,000 | 5.53% | ||
| 6 | BB BIOTECH AG | 2,700,737 | 29,573,000 | 5.31% | ||
| 7 | DEERFIELD MANAGEMENT COMPANY, L.P. | 2,465,129 | 26,993,000 | 4.85% | ||
| 8 | FMR LLC | 2,163,948 | 23,695,000 | 4.26% | ||
| 9 | WELLINGTON MANAGEMENT GROUP LLP | 2,024,524 | 22,169,000 | 3.98% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 1,421,160 | 15,562,000 | 2.80% | ||
| 11 | ACADIAN ASSET MANAGEMENT LLC | 1,251,479 | 13,705,000 | 2.46% | ||
| 12 | RENAISSANCE TECHNOLOGIES LLC | 1,198,350 | 13,122,000 | 2.36% | ||
| 13 | Numeric Investors LLC | 1,075,140 | 11,773,000 | 2.12% | ||
| 14 | OXFORD ASSET MANAGEMENT LLP | 710,398 | 7,779,000 | 1.40% | ||
| 15 | PRICE T ROWE ASSOCIATES INC /MD/ | 631,320 | 6,913,000 | 1.24% | ||
| 16 | BLACKROCK ADVISORS LLC | 611,678 | 6,697,000 | 1.20% | ||
| 17 | JPMORGAN CHASE & CO | 569,932 | 6,240,000 | 1.12% | ||
| 18 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 564,657 | 6,183,000 | 1.11% | ||
| 19 | NORTHERN TRUST CORP | 553,654 | 6,062,000 | 1.09% | ||
| 20 | TEACHERS ADVISORS, LLC | 510,671 | 5,592,000 | 1.00% | ||
| 21 | MILLENNIUM MANAGEMENT LLC | 456,221 | 4,996,000 | 0.90% | ||
| 22 | DEUTSCHE BANK AG\ | 438,221 | 4,796,000 | 0.86% | ||
| 23 | D. E. Shaw & Co., Inc. | 399,818 | 4,378,000 | 0.79% | ||
| 24 | DIMENSIONAL FUND ADVISORS LP | 385,937 | 4,225,000 | 0.76% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 372,536 | 4,079,000 | 0.73% | ||
| 26 | Invesco Ltd. | 368,812 | 4,039,000 | 0.73% | ||
| 27 | ROTHSCHILD & CO ASSET MANAGEMENT US INC. | 364,199 | 3,988,000 | 0.72% | ||
| 28 | I.G. INVESTMENT MANAGEMENT, LTD. | 363,751 | 3,983,000 | 0.72% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 355,894 | 3,896,000 | 0.70% | ||
| 30 | Cheyne Capital Management (UK) LLP | 350,604 | 3,841,000 | 0.69% | ||
| 31 | NORGES BANK | 318,079 | 3,482,000 | 0.63% | ||
| 32 | Bank of New York Mellon Corp | 288,960 | 3,163,000 | 0.57% | ||
| 33 | CREDIT SUISSE AG/ | 287,603 | 3,149,000 | 0.57% | ||
| 34 | RUSSELL FRANK CO/ | 269,881 | 2,955,000 | 0.53% | ||
| 35 | Candriam S.C.A. | 265,000 | 2,902,000 | 0.52% | ||
| 36 | PANAGORA ASSET MANAGEMENT INC | 243,246 | 2,664,000 | 0.48% | ||
| 37 | Rock Springs Capital Management LP | 215,000 | 2,354,000 | 0.42% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 191,300 | 2,095,000 | 0.38% | Put | |
| 39 | PDT Partners, LLC | 184,612 | 2,022,000 | 0.36% | ||
| 40 | QS Investors, LLC | 182,380 | 1,997,000 | 0.36% | ||
| 41 | A.R.T. Advisors, LLC | 180,925 | 1,981,000 | 0.36% | ||
| 42 | MORGAN STANLEY | 175,199 | 1,919,000 | 0.34% | ||
| 43 | BlackRock Investment Management, LLC | 173,975 | 1,905,000 | 0.34% | ||
| 44 | BELLEVUE ASSET MANAGEMENT AG | 164,000 | 1,796,000 | 0.32% | ||
| 45 | ALLIANCEBERNSTEIN L.P. | 144,330 | 1,580,000 | 0.28% | ||
| 46 | GLOBEFLEX CAPITAL L P | 139,091 | 1,523,000 | 0.27% | ||
| 47 | MARINER INVESTMENT GROUP LLC | 138,100 | 1,512,000 | 0.27% | ||
| 48 | AMERICAN CENTURY COMPANIES INC | 132,305 | 1,449,000 | 0.26% | ||
| 49 | Trexquant Investment LP | 129,300 | 1,415,000 | 0.25% | ||
| 50 | Nine Chapters Capital Management LLC | 114,500 | 1,254,000 | 0.23% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
