| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | VANGUARD GROUP INC | 5,611,888 | 47,421,000 | 10.83% | ||
| 2 | GOLDMAN SACHS GROUP INC | 5,386,540 | 45,516,000 | 10.39% | ||
| 3 | ORBIMED ADVISORS LLC | 4,416,300 | 37,318,000 | 8.52% | ||
| 4 | DEERFIELD MANAGEMENT COMPANY, L.P. | 3,910,721 | 33,046,000 | 7.54% | ||
| 5 | STATE STREET CORP | 3,731,632 | 31,531,000 | 7.20% | ||
| 6 | BlackRock Fund Advisors | 2,793,768 | 23,607,000 | 5.39% | ||
| 7 | BB BIOTECH AG | 2,700,737 | 22,821,000 | 5.21% | ||
| 8 | WELLINGTON MANAGEMENT GROUP LLP | 2,423,776 | 20,481,000 | 4.68% | ||
| 9 | FMR LLC | 2,096,367 | 17,714,000 | 4.04% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 1,377,356 | 11,639,000 | 2.66% | ||
| 11 | ACADIAN ASSET MANAGEMENT LLC | 1,031,894 | 8,718,000 | 1.99% | ||
| 12 | RENAISSANCE TECHNOLOGIES LLC | 877,500 | 7,415,000 | 1.69% | ||
| 13 | PRICE T ROWE ASSOCIATES INC /MD/ | 643,120 | 5,434,000 | 1.24% | ||
| 14 | BLACKROCK ADVISORS LLC | 619,685 | 5,236,000 | 1.20% | ||
| 15 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 601,022 | 5,079,000 | 1.16% | ||
| 16 | Redmile Group, LLC | 590,100 | 4,986,000 | 1.14% | ||
| 17 | NORTHERN TRUST CORP | 579,044 | 4,892,000 | 1.12% | ||
| 18 | JPMORGAN CHASE & CO | 572,175 | 4,835,000 | 1.10% | ||
| 19 | TEACHERS ADVISORS, LLC | 563,171 | 4,759,000 | 1.09% | ||
| 20 | NORGES BANK | 500,092 | 4,226,000 | 0.96% | ||
| 21 | Connor, Clark & Lunn Investment Management Ltd. | 481,375 | 4,068,000 | 0.93% | ||
| 22 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 469,045 | 3,963,000 | 0.90% | ||
| 23 | DEUTSCHE BANK AG\ | 394,738 | 3,333,000 | 0.76% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 364,678 | 3,080,000 | 0.70% | ||
| 25 | TIAA CREF INVESTMENT MANAGEMENT LLC | 359,204 | 3,035,000 | 0.69% | ||
| 26 | PANAGORA ASSET MANAGEMENT INC | 332,718 | 2,811,000 | 0.64% | ||
| 27 | I.G. INVESTMENT MANAGEMENT, LTD. | 332,200 | 2,807,000 | 0.64% | ||
| 28 | AMERIPRISE FINANCIAL INC | 328,424 | 2,775,000 | 0.63% | ||
| 29 | D. E. Shaw & Co., Inc. | 250,306 | 2,115,000 | 0.48% | ||
| 30 | CREDIT SUISSE AG/ | 249,792 | 2,112,000 | 0.48% | ||
| 31 | DIMENSIONAL FUND ADVISORS LP | 247,069 | 2,088,000 | 0.48% | ||
| 32 | Candriam S.C.A. | 240,900 | 2,036,000 | 0.46% | ||
| 33 | Bank of New York Mellon Corp | 237,780 | 2,009,000 | 0.46% | ||
| 34 | Cheyne Capital Management (UK) LLP | 220,618 | 1,863,000 | 0.43% | ||
| 35 | RUSSELL FRANK CO/ | 218,981 | 1,851,000 | 0.42% | ||
| 36 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 215,300 | 1,819,000 | 0.42% | Put | |
| 37 | Rock Springs Capital Management LP | 215,000 | 1,817,000 | 0.41% | ||
| 38 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 209,600 | 1,771,000 | 0.40% | Call | |
| 39 | EVENTIDE ASSET MANAGEMENT, LLC | 197,100 | 1,665,000 | 0.38% | ||
| 40 | Nine Chapters Capital Management LLC | 190,200 | 1,607,000 | 0.37% | ||
| 41 | QS Investors, LLC | 182,380 | 1,541,000 | 0.35% | ||
| 42 | MILLENNIUM MANAGEMENT LLC | 182,088 | 1,539,000 | 0.35% | ||
| 43 | Numeric Investors LLC | 181,199 | 1,531,000 | 0.35% | ||
| 44 | ROTHSCHILD & CO ASSET MANAGEMENT US INC. | 179,187 | 1,514,000 | 0.35% | ||
| 45 | BlackRock Investment Management, LLC | 172,757 | 1,460,000 | 0.33% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 151,000 | 1,276,000 | 0.29% | Put | |
| 47 | EverPoint Asset Management, LLC | 150,000 | 1,268,000 | 0.29% | ||
| 48 | GLOBEFLEX CAPITAL L P | 146,473 | 1,238,000 | 0.28% | ||
| 49 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 144,594 | 1,222,000 | 0.28% | ||
| 50 | MARINER INVESTMENT GROUP LLC | 138,100 | 1,167,000 | 0.27% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
