| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 4,736,900 | 80,006,000 | 10.01% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 3,857,805 | 65,158,000 | 8.15% | ||
| 3 | VANGUARD GROUP INC | 3,485,017 | 58,863,000 | 7.37% | ||
| 4 | FMR LLC | 3,251,242 | 54,913,000 | 6.87% | ||
| 5 | GOLDMAN SACHS GROUP INC | 2,783,407 | 47,012,000 | 5.88% | ||
| 6 | BlackRock Fund Advisors | 2,444,554 | 41,289,000 | 5.17% | ||
| 7 | BB BIOTECH AG | 2,320,737 | 39,197,000 | 4.90% | ||
| 8 | WELLINGTON MANAGEMENT GROUP LLP | 1,854,495 | 31,322,000 | 3.92% | ||
| 9 | STATE STREET CORP | 1,729,006 | 29,205,000 | 3.65% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 1,410,551 | 23,824,000 | 2.98% | ||
| 11 | MILLENNIUM MANAGEMENT LLC | 1,241,145 | 20,963,000 | 2.62% | ||
| 12 | PRICE T ROWE ASSOCIATES INC /MD/ | 892,070 | 15,067,000 | 1.89% | ||
| 13 | BLACKROCK ADVISORS LLC | 645,630 | 10,904,000 | 1.36% | ||
| 14 | GREAT POINT PARTNERS LLC | 625,000 | 10,556,000 | 1.32% | ||
| 15 | OXFORD ASSET MANAGEMENT LLP | 582,089 | 9,931,000 | 1.24% | ||
| 16 | NORTHERN TRUST CORP | 534,958 | 9,035,000 | 1.13% | ||
| 17 | GOLDMAN SACHS GROUP INC | 463,800 | 7,834,000 | 0.98% | Put | |
| 18 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 461,902 | 7,801,000 | 0.98% | ||
| 19 | TEACHERS ADVISORS, LLC | 455,901 | 7,700,000 | 0.96% | ||
| 20 | Broadfin Capital, LLC | 450,000 | 7,601,000 | 0.95% | ||
| 21 | CITADEL ADVISORS LLC | 448,247 | 7,571,000 | 0.95% | ||
| 22 | Tekla Capital Management LLC | 438,623 | 7,408,000 | 0.93% | ||
| 23 | DEUTSCHE BANK AG\ | 421,349 | 7,114,000 | 0.89% | ||
| 24 | Invesco Ltd. | 416,268 | 7,031,000 | 0.88% | ||
| 25 | BALYASNY ASSET MANAGEMENT L.P. | 412,656 | 6,970,000 | 0.87% | ||
| 26 | Cheyne Capital Management (UK) LLP | 409,715 | 6,922,000 | 0.87% | ||
| 27 | Numeric Investors LLC | 401,398 | 6,780,000 | 0.85% | ||
| 28 | DIMENSIONAL FUND ADVISORS LP | 390,650 | 6,598,000 | 0.83% | ||
| 29 | D. E. Shaw & Co., Inc. | 378,473 | 6,392,000 | 0.80% | ||
| 30 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 377,712 | 6,380,000 | 0.80% | ||
| 31 | TFS CAPITAL LLC | 347,088 | 5,862,000 | 0.73% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 337,641 | 5,701,000 | 0.71% | ||
| 33 | LORD, ABBETT & CO. LLC | 326,054 | 5,507,000 | 0.69% | ||
| 34 | BAKER BROS. ADVISORS LP | 312,025 | 5,270,000 | 0.66% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 303,400 | 5,124,000 | 0.64% | Put | |
| 36 | Bank of New York Mellon Corp | 295,851 | 4,997,000 | 0.63% | ||
| 37 | DRIEHAUS CAPITAL MANAGEMENT LLC | 253,338 | 4,279,000 | 0.54% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 251,400 | 4,246,000 | 0.53% | Call | |
| 39 | NORGES BANK | 245,918 | 4,154,000 | 0.52% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 245,557 | 4,147,000 | 0.52% | ||
| 41 | Candriam S.C.A. | 235,000 | 3,969,000 | 0.50% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 225,538 | 3,809,000 | 0.48% | ||
| 43 | HealthCor Management, L.P. | 223,712 | 3,778,000 | 0.47% | ||
| 44 | MORGAN STANLEY | 220,112 | 3,719,000 | 0.47% | ||
| 45 | ACADIAN ASSET MANAGEMENT LLC | 217,014 | 3,667,000 | 0.46% | ||
| 46 | Rock Springs Capital Management LP | 210,000 | 3,547,000 | 0.44% | ||
| 47 | RENAISSANCE TECHNOLOGIES LLC | 201,600 | 3,405,000 | 0.43% | ||
| 48 | GUGGENHEIM CAPITAL LLC | 183,942 | 3,107,000 | 0.39% | ||
| 49 | CREDIT SUISSE AG/ | 179,530 | 3,033,000 | 0.38% | ||
| 50 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 150,000 | 2,534,000 | 0.32% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
