| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | VANGUARD GROUP INC | 6,595,749 | 8,773,000 | 16.77% | ||
| 2 | BVF INC/IL | 5,184,600 | 6,896,000 | 13.18% | ||
| 3 | ORBIMED ADVISORS LLC | 3,250,300 | 4,323,000 | 8.26% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 2,763,429 | 3,676,000 | 7.03% | ||
| 5 | BlackRock Fund Advisors | 1,960,489 | 2,607,000 | 4.98% | ||
| 6 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,935,942 | 2,575,000 | 4.92% | ||
| 7 | BlackRock Institutional Trust Company, N.A. | 1,358,322 | 1,807,000 | 3.45% | ||
| 8 | FMR LLC | 1,086,500 | 1,445,000 | 2.76% | ||
| 9 | STATE STREET CORP | 1,026,314 | 1,367,000 | 2.61% | ||
| 10 | Numeric Investors LLC | 843,823 | 1,122,000 | 2.14% | ||
| 11 | OXFORD ASSET MANAGEMENT LLP | 771,506 | 1,026,000 | 1.96% | ||
| 12 | RENAISSANCE TECHNOLOGIES LLC | 749,700 | 997,000 | 1.91% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 714,363 | 950,000 | 1.82% | ||
| 14 | NORTHERN TRUST CORP | 710,320 | 945,000 | 1.81% | ||
| 15 | I.G. INVESTMENT MANAGEMENT, LTD. | 700,000 | 931,000 | 1.78% | ||
| 16 | Connor, Clark & Lunn Investment Management Ltd. | 651,275 | 866,000 | 1.66% | ||
| 17 | PLATINUM INVESTMENT MANAGEMENT LTD | 498,232 | 662,000 | 1.27% | ||
| 18 | JPMORGAN CHASE & CO | 462,200 | 614,000 | 1.17% | ||
| 19 | NORGES BANK | 402,625 | 536,000 | 1.02% | ||
| 20 | AMERIPRISE FINANCIAL INC | 363,835 | 484,000 | 0.93% | ||
| 21 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 345,446 | 459,000 | 0.88% | ||
| 22 | ACADIAN ASSET MANAGEMENT LLC | 335,203 | 446,000 | 0.85% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 315,401 | 419,000 | 0.80% | ||
| 24 | CREDIT SUISSE AG/ | 314,181 | 418,000 | 0.80% | ||
| 25 | DEUTSCHE BANK AG\ | 311,353 | 410,000 | 0.78% | ||
| 26 | TUDOR INVESTMENT CORP ET AL | 277,600 | 369,000 | 0.71% | ||
| 27 | Rock Springs Capital Management LP | 270,000 | 359,000 | 0.69% | ||
| 28 | Bank of New York Mellon Corp | 254,019 | 336,000 | 0.64% | ||
| 29 | ASCEND CAPITAL, LLC | 250,000 | 334,000 | 0.64% | ||
| 30 | D. E. Shaw & Co., Inc. | 228,615 | 305,000 | 0.58% | ||
| 31 | Candriam S.C.A. | 209,000 | 278,000 | 0.53% | ||
| 32 | GLOBEFLEX CAPITAL L P | 204,399 | 272,000 | 0.52% | ||
| 33 | BlackRock Investment Management, LLC | 186,575 | 248,000 | 0.47% | ||
| 34 | QS Investors, LLC | 182,380 | 243,000 | 0.46% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 178,736 | 238,000 | 0.45% | ||
| 36 | GOLDMAN SACHS GROUP INC | 165,876 | 221,000 | 0.42% | ||
| 37 | BELLEVUE GROUP AG | 160,000 | 213,000 | 0.41% | ||
| 38 | A.R.T. Advisors, LLC | 158,507 | 210,000 | 0.40% | ||
| 39 | Jefferies Group LLC | 130,000 | 173,000 | 0.33% | Call | |
| 40 | ALLIANCEBERNSTEIN L.P. | 112,210 | 149,000 | 0.28% | ||
| 41 | PRICE T ROWE ASSOCIATES INC /MD/ | 110,600 | 147,000 | 0.28% | ||
| 42 | BLACKROCK ADVISORS LLC | 110,510 | 147,000 | 0.28% | ||
| 43 | TWO SIGMA INVESTMENTS, LP | 107,301 | 143,000 | 0.27% | ||
| 44 | BlackRock Finance, Inc. | 107,958 | 143,000 | 0.27% | ||
| 45 | Evercore Wealth Management, LLC | 107,091 | 142,000 | 0.27% | ||
| 46 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 102,177 | 136,000 | 0.26% | ||
| 47 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 98,300 | 131,000 | 0.25% | ||
| 48 | TWO SIGMA ADVISERS, LP | 96,563 | 128,000 | 0.24% | ||
| 49 | PANAGORA ASSET MANAGEMENT INC | 90,048 | 120,000 | 0.23% | ||
| 50 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 87,100 | 116,000 | 0.22% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
