| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | VANGUARD GROUP INC | 4,822,844 | 67,423,000 | 9.70% | ||
| 2 | ORBIMED ADVISORS LLC | 4,264,900 | 59,623,000 | 8.58% | ||
| 3 | DEERFIELD MANAGEMENT COMPANY, L.P. | 3,968,155 | 55,475,000 | 7.98% | ||
| 4 | GOLDMAN SACHS GROUP INC | 3,686,699 | 51,540,000 | 7.42% | ||
| 5 | BB BIOTECH AG | 2,620,737 | 36,638,000 | 5.27% | ||
| 6 | BlackRock Fund Advisors | 2,582,262 | 36,100,000 | 5.19% | ||
| 7 | FMR LLC | 2,407,942 | 33,663,000 | 4.84% | ||
| 8 | STATE STREET CORP | 2,349,630 | 32,846,000 | 4.73% | ||
| 9 | WELLINGTON MANAGEMENT GROUP LLP | 1,992,353 | 27,852,000 | 4.01% | ||
| 10 | Invesco Ltd. | 1,484,322 | 20,751,000 | 2.99% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 1,435,644 | 20,070,000 | 2.89% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 891,222 | 12,459,000 | 1.79% | ||
| 13 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 826,210 | 11,551,000 | 1.66% | ||
| 14 | ACADIAN ASSET MANAGEMENT LLC | 775,732 | 10,844,000 | 1.56% | ||
| 15 | Numeric Investors LLC | 684,740 | 9,573,000 | 1.38% | ||
| 16 | RENAISSANCE TECHNOLOGIES LLC | 668,000 | 9,339,000 | 1.34% | ||
| 17 | BLACKROCK ADVISORS LLC | 658,097 | 9,200,000 | 1.32% | ||
| 18 | PRICE T ROWE ASSOCIATES INC /MD/ | 622,720 | 8,706,000 | 1.25% | ||
| 19 | DEUTSCHE BANK AG\ | 552,201 | 7,718,000 | 1.11% | ||
| 20 | NORTHERN TRUST CORP | 540,193 | 7,551,000 | 1.09% | ||
| 21 | CITADEL ADVISORS LLC | 531,294 | 7,428,000 | 1.07% | ||
| 22 | TEACHERS ADVISORS, LLC | 499,301 | 6,980,000 | 1.00% | ||
| 23 | Cheyne Capital Management (UK) LLP | 483,262 | 6,754,000 | 0.97% | ||
| 24 | D. E. Shaw & Co., Inc. | 473,576 | 6,621,000 | 0.95% | ||
| 25 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 461,902 | 6,457,000 | 0.93% | ||
| 26 | JPMORGAN CHASE & CO | 439,702 | 6,146,000 | 0.88% | ||
| 27 | Tekla Capital Management LLC | 438,623 | 6,132,000 | 0.88% | ||
| 28 | DIMENSIONAL FUND ADVISORS LP | 390,650 | 5,462,000 | 0.79% | ||
| 29 | ROTHSCHILD & CO ASSET MANAGEMENT US INC. | 356,191 | 4,980,000 | 0.72% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 352,633 | 4,930,000 | 0.71% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 323,971 | 4,528,000 | 0.65% | ||
| 32 | BAKER BROS. ADVISORS LP | 305,037 | 4,264,000 | 0.61% | ||
| 33 | Bank of New York Mellon Corp | 302,574 | 4,229,000 | 0.61% | ||
| 34 | OXFORD ASSET MANAGEMENT LLP | 291,066 | 4,069,000 | 0.59% | ||
| 35 | NORGES BANK | 288,379 | 4,032,000 | 0.58% | ||
| 36 | Candriam S.C.A. | 265,000 | 3,706,000 | 0.53% | ||
| 37 | CREDIT SUISSE AG/ | 225,839 | 3,158,000 | 0.45% | ||
| 38 | Rock Springs Capital Management LP | 215,000 | 3,006,000 | 0.43% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 189,500 | 2,649,000 | 0.38% | Put | |
| 40 | RUSSELL FRANK CO/ | 183,234 | 2,562,000 | 0.37% | ||
| 41 | QS Investors, LLC | 182,380 | 2,549,000 | 0.37% | ||
| 42 | PRUDENTIAL FINANCIAL INC | 177,943 | 2,488,000 | 0.36% | ||
| 43 | AMERICAN CENTURY COMPANIES INC | 168,989 | 2,362,000 | 0.34% | ||
| 44 | BELLEVUE ASSET MANAGEMENT AG | 164,000 | 2,293,000 | 0.33% | ||
| 45 | PDT Partners, LLC | 162,941 | 2,278,000 | 0.33% | ||
| 46 | MORGAN STANLEY | 161,207 | 2,254,000 | 0.32% | ||
| 47 | BlackRock Investment Management, LLC | 141,774 | 1,982,000 | 0.29% | ||
| 48 | AMERICAFIRST CAPITAL MANAGEMENT, LLC | 123,787 | 1,730,542 | 0.25% | ||
| 49 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 107,600 | 1,704,000 | 0.25% | ||
| 50 | PANAGORA ASSET MANAGEMENT INC | 121,309 | 1,696,000 | 0.24% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
