| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | VANGUARD GROUP INC | 5,902,053 | 9,206,000 | 15.38% | ||
| 2 | BVF INC/IL | 5,149,644 | 8,033,000 | 13.42% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 4,344,581 | 6,778,000 | 11.32% | ||
| 4 | ORBIMED ADVISORS LLC | 3,250,300 | 5,070,000 | 8.47% | ||
| 5 | BlackRock Fund Advisors | 2,067,943 | 3,226,000 | 5.39% | ||
| 6 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,935,942 | 3,020,000 | 5.05% | ||
| 7 | RENAISSANCE TECHNOLOGIES LLC | 1,860,900 | 2,903,000 | 4.85% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 1,455,317 | 2,270,000 | 3.79% | ||
| 9 | FMR LLC | 1,146,500 | 1,789,000 | 2.99% | ||
| 10 | STATE STREET CORP | 1,031,377 | 1,610,000 | 2.69% | ||
| 11 | NORTHERN TRUST CORP | 770,632 | 1,202,000 | 2.01% | ||
| 12 | Numeric Investors LLC | 760,899 | 1,187,000 | 1.98% | ||
| 13 | Connor, Clark & Lunn Investment Management Ltd. | 694,875 | 1,084,000 | 1.81% | ||
| 14 | BAKER BROS. ADVISORS LP | 580,400 | 905,000 | 1.51% | ||
| 15 | DEUTSCHE BANK AG\ | 581,435 | 905,000 | 1.51% | ||
| 16 | PLATINUM INVESTMENT MANAGEMENT LTD | 498,232 | 777,000 | 1.30% | ||
| 17 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 341,090 | 532,000 | 0.89% | ||
| 18 | GEODE CAPITAL MANAGEMENT, LLC | 319,410 | 498,000 | 0.83% | ||
| 19 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 293,800 | 458,000 | 0.77% | ||
| 20 | PRICE T ROWE ASSOCIATES INC /MD/ | 283,960 | 443,000 | 0.74% | ||
| 21 | Rock Springs Capital Management LP | 270,000 | 421,000 | 0.70% | ||
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 250,879 | 391,000 | 0.65% | ||
| 23 | CREDIT SUISSE AG/ | 249,597 | 389,000 | 0.65% | ||
| 24 | D. E. Shaw & Co., Inc. | 243,767 | 381,000 | 0.64% | ||
| 25 | JPMORGAN CHASE & CO | 233,900 | 365,000 | 0.61% | ||
| 26 | Bank of New York Mellon Corp | 213,139 | 332,000 | 0.55% | ||
| 27 | OXFORD ASSET MANAGEMENT LLP | 209,862 | 327,000 | 0.55% | ||
| 28 | Candriam S.C.A. | 209,000 | 326,000 | 0.54% | ||
| 29 | GOLDMAN SACHS GROUP INC | 201,134 | 314,000 | 0.52% | ||
| 30 | BlackRock Investment Management, LLC | 185,871 | 290,000 | 0.48% | ||
| 31 | QS Investors, LLC | 182,380 | 285,000 | 0.48% | ||
| 32 | MILLENNIUM MANAGEMENT LLC | 154,342 | 241,000 | 0.40% | ||
| 33 | ACADIAN ASSET MANAGEMENT LLC | 137,093 | 213,000 | 0.36% | ||
| 34 | BLACKROCK ADVISORS LLC | 112,709 | 176,000 | 0.29% | ||
| 35 | ALLIANCEBERNSTEIN L.P. | 112,210 | 175,000 | 0.29% | ||
| 36 | SG Americas Securities, LLC | 111,811 | 174,000 | 0.29% | ||
| 37 | BlackRock Finance, Inc. | 107,958 | 168,000 | 0.28% | ||
| 38 | Evercore Wealth Management, LLC | 107,091 | 167,000 | 0.28% | ||
| 39 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 103,977 | 162,000 | 0.27% | ||
| 40 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 91,900 | 143,000 | 0.24% | ||
| 41 | PANAGORA ASSET MANAGEMENT INC | 85,544 | 133,000 | 0.22% | ||
| 42 | RHUMBLINE ADVISERS | 82,589 | 129,000 | 0.22% | ||
| 43 | BANK OF AMERICA CORP /DE/ | 81,430 | 127,000 | 0.21% | ||
| 44 | Swiss National Bank | 77,900 | 122,000 | 0.20% | ||
| 45 | TEACHERS ADVISORS, LLC | 76,001 | 119,000 | 0.20% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 67,500 | 106,000 | 0.18% | ||
| 47 | ALPS ADVISORS INC | 63,217 | 99,000 | 0.17% | ||
| 48 | BESSEMER GROUP INC | 61,888 | 97,000 | 0.16% | ||
| 49 | TWO SIGMA ADVISERS, LP | 55,463 | 87,000 | 0.15% | ||
| 50 | Quantitative Investment Management, LLC | 52,100 | 81,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
