| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ORBIMED ADVISORS LLC | 4,736,900 | 63,569,000 | 9.95% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 3,882,805 | 52,107,000 | 8.15% | ||
| 3 | FMR LLC | 3,373,942 | 45,278,000 | 7.08% | ||
| 4 | GOLDMAN SACHS GROUP INC | 3,150,026 | 42,274,000 | 6.61% | ||
| 5 | VANGUARD GROUP INC | 2,723,533 | 36,550,000 | 5.72% | ||
| 6 | BB BIOTECH AG | 2,320,737 | 31,144,000 | 4.87% | ||
| 7 | BlackRock Fund Advisors | 2,149,839 | 28,851,000 | 4.51% | ||
| 8 | WELLINGTON MANAGEMENT GROUP LLP | 1,763,011 | 23,660,000 | 3.70% | ||
| 9 | STATE STREET CORP | 1,728,984 | 23,200,000 | 3.63% | ||
| 10 | Point72 Asset Management, L.P. | 1,700,000 | 22,814,000 | 3.57% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 1,317,849 | 17,686,000 | 2.77% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 1,208,980 | 16,225,000 | 2.54% | ||
| 13 | HealthCor Management, L.P. | 1,162,200 | 15,597,000 | 2.44% | ||
| 14 | GREAT POINT PARTNERS LLC | 1,100,000 | 14,762,000 | 2.31% | ||
| 15 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,025,220 | 13,758,000 | 2.15% | ||
| 16 | BARCLAYS PLC | 947,900 | 12,323,000 | 1.93% | Put | |
| 17 | Broadfin Capital, LLC | 854,384 | 11,466,000 | 1.79% | ||
| 18 | Tekla Capital Management LLC | 680,746 | 9,136,000 | 1.43% | ||
| 19 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 600,000 | 8,052,000 | 1.26% | ||
| 20 | NORTHERN TRUST CORP | 541,481 | 7,266,000 | 1.14% | ||
| 21 | Point72 Asset Management, L.P. | 500,000 | 6,710,000 | 1.05% | Call | |
| 22 | D. E. Shaw & Co., Inc. | 478,607 | 6,423,000 | 1.01% | ||
| 23 | BLACKROCK ADVISORS LLC | 469,443 | 6,300,000 | 0.99% | ||
| 24 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 467,491 | 6,273,000 | 0.98% | ||
| 25 | DEUTSCHE BANK AG\ | 412,658 | 5,535,000 | 0.87% | ||
| 26 | DIMENSIONAL FUND ADVISORS LP | 390,650 | 5,243,000 | 0.82% | ||
| 27 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 347,365 | 4,662,000 | 0.73% | ||
| 28 | NORGES BANK | 343,291 | 4,607,000 | 0.72% | ||
| 29 | Cheyne Capital Management (UK) LLP | 326,821 | 4,388,000 | 0.69% | ||
| 30 | LORD, ABBETT & CO. LLC | 321,964 | 4,321,000 | 0.68% | ||
| 31 | BAKER BROS. ADVISORS LP | 312,025 | 4,187,000 | 0.66% | ||
| 32 | I.G. INVESTMENT MANAGEMENT, LTD. | 305,451 | 4,099,000 | 0.64% | ||
| 33 | Bank of New York Mellon Corp | 302,906 | 4,065,000 | 0.64% | ||
| 34 | BARCLAYS PLC | 305,966 | 3,978,000 | 0.62% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 277,200 | 3,720,000 | 0.58% | Put | |
| 36 | TEACHERS ADVISORS, LLC | 250,201 | 3,358,000 | 0.53% | ||
| 37 | GOLDMAN SACHS GROUP INC | 249,600 | 3,350,000 | 0.52% | Put | |
| 38 | GEODE CAPITAL MANAGEMENT, LLC | 237,494 | 3,187,000 | 0.50% | ||
| 39 | AMERIPRISE FINANCIAL INC | 221,198 | 2,968,000 | 0.46% | ||
| 40 | MORGAN STANLEY | 211,868 | 2,843,000 | 0.44% | ||
| 41 | Rock Springs Capital Management LP | 210,000 | 2,818,000 | 0.44% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 197,600 | 2,652,000 | 0.41% | Call | |
| 43 | TIAA CREF INVESTMENT MANAGEMENT LLC | 179,333 | 2,407,000 | 0.38% | ||
| 44 | CREDIT SUISSE AG/ | 157,438 | 2,113,000 | 0.33% | ||
| 45 | Rhenman & Partners Asset Management AB | 148,000 | 1,986,000 | 0.31% | ||
| 46 | BlackRock Investment Management, LLC | 140,853 | 1,890,000 | 0.30% | ||
| 47 | ROYCE & ASSOCIATES LP | 135,400 | 1,817,000 | 0.28% | ||
| 48 | UBS AG | 131,500 | 1,765,000 | 0.28% | Put | |
| 49 | TURNER INVESTMENTS LLC | 130,470 | 1,751,000 | 0.27% | ||
| 50 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 120,589 | 1,619,000 | 0.25% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
