| 1 |
BVF INC/IL |
7,866,108 |
25,408,000 |
20.97% |
|
|
| 2 |
VANGUARD GROUP INC |
4,701,769 |
15,187,000 |
12.54% |
|
|
| 3 |
WELLINGTON MANAGEMENT GROUP LLP |
4,565,947 |
14,748,000 |
12.17% |
|
|
| 4 |
ORBIMED ADVISORS LLC |
3,250,300 |
10,498,000 |
8.67% |
|
|
| 5 |
BlackRock Finance, Inc. |
3,001,051 |
9,693,000 |
8.00% |
|
|
| 6 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
1,969,225 |
6,361,000 |
5.25% |
|
|
| 7 |
RENAISSANCE TECHNOLOGIES LLC |
1,439,241 |
4,649,000 |
3.84% |
|
|
| 8 |
STATE STREET CORP |
1,116,117 |
3,605,000 |
2.98% |
|
|
| 9 |
PLATINUM INVESTMENT MANAGEMENT LTD |
810,232 |
2,617,000 |
2.16% |
|
|
| 10 |
NORTHERN TRUST CORP |
759,909 |
2,454,000 |
2.03% |
|
|
| 11 |
Connor, Clark & Lunn Investment Management Ltd. |
668,040 |
2,158,000 |
1.78% |
|
|
| 12 |
ACADIAN ASSET MANAGEMENT LLC |
585,232 |
1,888,000 |
1.56% |
|
|
| 13 |
BAKER BROS. ADVISORS LP |
580,400 |
1,875,000 |
1.55% |
|
|
| 14 |
DIMENSIONAL FUND ADVISORS LP |
491,667 |
1,588,000 |
1.31% |
|
|
| 15 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
391,671 |
1,265,000 |
1.04% |
|
|
| 16 |
GEODE CAPITAL MANAGEMENT, LLC |
345,366 |
1,114,000 |
0.92% |
|
|
| 17 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
289,000 |
933,000 |
0.77% |
|
|
| 18 |
MILLENNIUM MANAGEMENT LLC |
272,393 |
880,000 |
0.73% |
|
|
| 19 |
BOGLE INVESTMENT MANAGEMENT L P /DE/ |
270,417 |
873,000 |
0.72% |
|
|
| 20 |
Rock Springs Capital Management LP |
270,000 |
872,000 |
0.72% |
|
|
| 21 |
PRICE T ROWE ASSOCIATES INC /MD/ |
267,595 |
864,000 |
0.71% |
|
|
| 22 |
DEUTSCHE BANK AG\ |
238,758 |
769,000 |
0.63% |
|
|
| 23 |
JPMORGAN CHASE & CO |
226,101 |
730,000 |
0.60% |
|
|
| 24 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
213,942 |
691,000 |
0.57% |
|
|
| 25 |
RUSSELL INVESTMENTS GROUP, LTD. |
208,238 |
673,000 |
0.56% |
|
|
| 26 |
D. E. Shaw & Co., Inc. |
196,464 |
634,000 |
0.52% |
|
|
| 27 |
QS Investors, LLC |
182,380 |
589,000 |
0.49% |
|
|
| 28 |
Bank of New York Mellon Corp |
170,649 |
551,000 |
0.45% |
|
|
| 29 |
GOLDMAN SACHS GROUP INC |
140,737 |
455,000 |
0.38% |
|
|
| 30 |
Numeric Investors LLC |
120,855 |
390,000 |
0.32% |
|
|
| 31 |
TEACHERS ADVISORS, LLC |
117,028 |
378,000 |
0.31% |
|
|
| 32 |
ALLIANCEBERNSTEIN L.P. |
110,000 |
355,000 |
0.29% |
|
|
| 33 |
Evercore Wealth Management, LLC |
107,091 |
346,000 |
0.29% |
|
|
| 34 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
98,777 |
319,000 |
0.26% |
|
|
| 35 |
Nationwide Fund Advisors |
96,918 |
313,000 |
0.26% |
|
|
| 36 |
Nine Chapters Capital Management LLC |
91,500 |
296,000 |
0.24% |
|
|
| 37 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
88,100 |
285,000 |
0.24% |
|
|
| 38 |
CITADEL ADVISORS LLC |
86,522 |
279,000 |
0.23% |
|
|
| 39 |
WELLS FARGO & COMPANY/MN |
81,493 |
263,000 |
0.22% |
|
|
| 40 |
Parallax Volatility Advisers, L.P. |
76,600 |
247,000 |
0.20% |
Put |
|
| 41 |
MORGAN STANLEY |
68,505 |
221,000 |
0.18% |
|
|
| 42 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
67,700 |
219,000 |
0.18% |
Call |
|
| 43 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
67,500 |
219,000 |
0.18% |
|
|
| 44 |
RHUMBLINE ADVISERS |
65,077 |
210,000 |
0.17% |
|
|
| 45 |
PRELUDE CAPITAL MANAGEMENT, LLC |
53,700 |
173,000 |
0.14% |
|
|
| 46 |
NEW YORK STATE COMMON RETIREMENT FUND |
44,801 |
145,000 |
0.12% |
|
|
| 47 |
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
40,813 |
132,000 |
0.11% |
|
|
| 48 |
AMERICAN FINANCIAL GROUP INC |
40,000 |
130,000 |
0.11% |
|
|
| 49 |
ALGERT GLOBAL LLC |
39,876 |
129,000 |
0.11% |
|
|
| 50 |
ADVISOR GROUP, INC. |
34,490 |
111,000 |
0.09% |
|
|
