| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,629,800 | 64,461,000 | 10.75% | ||
| 2 | BlackRock Finance, Inc. | 3,837,036 | 43,935,000 | 7.33% | ||
| 3 | VANGUARD GROUP INC | 3,626,573 | 41,525,000 | 6.92% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 3,597,231 | 41,188,000 | 6.87% | ||
| 5 | JANUS HENDERSON GROUP PLC | 3,227,558 | 36,956,000 | 6.16% | ||
| 6 | Redmile Group, LLC | 2,223,811 | 25,463,000 | 4.25% | ||
| 7 | FORESITE CAPITAL MANAGEMENT III, LLC | 2,177,203 | 24,929,000 | 4.16% | ||
| 8 | STATE STREET CORP | 1,944,755 | 22,267,000 | 3.71% | ||
| 9 | BB BIOTECH AG | 1,941,008 | 22,225,000 | 3.71% | ||
| 10 | EAGLE ASSET MANAGEMENT INC | 1,756,507 | 20,112,000 | 3.35% | ||
| 11 | ALLIANCEBERNSTEIN L.P. | 1,478,616 | 16,930,000 | 2.82% | ||
| 12 | TPG Group Holdings (SBS) Advisors, Inc. | 1,238,533 | 14,181,000 | 2.36% | ||
| 13 | EMERALD ADVISERS, LLC | 1,193,672 | 13,668,000 | 2.28% | ||
| 14 | Foresite Capital Management II, LLC | 1,043,832 | 11,952,000 | 1.99% | ||
| 15 | PRICE T ROWE ASSOCIATES INC /MD/ | 985,529 | 11,284,000 | 1.88% | ||
| 16 | EMERALD MUTUAL FUND ADVISERS TRUST | 942,709 | 10,794,000 | 1.80% | ||
| 17 | Cormorant Asset Management, LP | 900,000 | 10,305,000 | 1.72% | SH | |
| 18 | PICTET ASSET MANAGEMENT LTD | 636,250 | 9,798,000 | 1.63% | ||
| 19 | PFM Health Sciences, LP | 834,191 | 9,551,000 | 1.59% | ||
| 20 | MORGAN STANLEY | 734,579 | 8,411,000 | 1.40% | ||
| 21 | GOLDMAN SACHS GROUP INC | 718,389 | 8,226,000 | 1.37% | ||
| 22 | CITADEL ADVISORS LLC | 706,288 | 8,086,000 | 1.35% | ||
| 23 | AMERIPRISE FINANCIAL INC | 619,938 | 7,098,000 | 1.18% | ||
| 24 | NORTHERN TRUST CORP | 569,291 | 6,518,000 | 1.09% | ||
| 25 | SENZAR ASSET MANAGEMENT, LLC | 557,770 | 6,386,000 | 1.06% | ||
| 26 | BROWN ADVISORY INC | 537,835 | 6,158,000 | 1.03% | ||
| 27 | AMUNDI ASSET MANAGEMENT US, INC. | 467,813 | 5,356,000 | 0.89% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 416,893 | 4,773,000 | 0.80% | ||
| 29 | Invesco Ltd. | 392,545 | 4,494,000 | 0.75% | ||
| 30 | ING GROEP NV | 335,000 | 3,836,000 | 0.64% | ||
| 31 | AXA S.A. | 330,830 | 3,788,000 | 0.63% | ||
| 32 | Artal Group S.A. | 300,000 | 3,435,000 | 0.57% | ||
| 33 | Point72 Asset Management, L.P. | 269,800 | 3,089,000 | 0.52% | ||
| 34 | MILLENNIUM MANAGEMENT LLC | 250,000 | 2,863,000 | 0.48% | Put | |
| 35 | Ghost Tree Capital, LLC | 250,000 | 2,863,000 | 0.48% | ||
| 36 | JPMORGAN CHASE & CO | 235,603 | 2,697,000 | 0.45% | ||
| 37 | Bank of New York Mellon Corp | 232,287 | 2,659,000 | 0.44% | ||
| 38 | DAFNA Capital Management LLC | 221,013 | 2,531,000 | 0.42% | ||
| 39 | BAKER BROS. ADVISORS LP | 217,328 | 2,488,000 | 0.41% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 195,446 | 2,238,000 | 0.37% | ||
| 41 | Rock Springs Capital Management LP | 182,000 | 2,084,000 | 0.35% | ||
| 42 | New Leaf Venture Partners, L.L.C. | 171,364 | 1,962,000 | 0.33% | ||
| 43 | NORGES BANK | 170,179 | 1,949,000 | 0.32% | ||
| 44 | ASYMMETRY CAPITAL MANAGEMENT, L.P. | 166,752 | 1,909,000 | 0.32% | ||
| 45 | DEUTSCHE BANK AG\ | 166,583 | 1,905,000 | 0.32% | ||
| 46 | TIAA CREF INVESTMENT MANAGEMENT LLC | 165,344 | 1,893,000 | 0.32% | ||
| 47 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 147,709 | 1,691,000 | 0.28% | ||
| 48 | Fiera Capital Corp | 145,658 | 1,667,000 | 0.28% | ||
| 49 | DIMENSIONAL FUND ADVISORS LP | 144,757 | 1,657,000 | 0.28% | ||
| 50 | WELLS FARGO & COMPANY/MN | 135,071 | 1,547,000 | 0.26% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
