| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,438,757 | 210,208,000 | 12.12% | ||
| 2 | BB BIOTECH AG | 4,540,399 | 175,486,000 | 10.12% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,971,461 | 153,497,000 | 8.85% | ||
| 4 | MPM ASSET MANAGEMENT LLC | 3,887,502 | 150,252,000 | 8.66% | ||
| 5 | FARALLON CAPITAL MANAGEMENT LLC | 3,117,000 | 120,472,000 | 6.95% | ||
| 6 | VANGUARD GROUP INC | 3,010,646 | 116,362,000 | 6.71% | ||
| 7 | BlackRock Finance, Inc. | 2,630,745 | 101,679,000 | 5.86% | ||
| 8 | STATE STREET CORP | 1,654,132 | 63,932,000 | 3.69% | ||
| 9 | Tourbillon Capital Partners, L.P. | 1,489,137 | 57,555,000 | 3.32% | ||
| 10 | Bain Capital Public Equity Management, LLC | 1,156,330 | 44,692,000 | 2.58% | ||
| 11 | JENNISON ASSOCIATES LLC | 957,056 | 36,990,000 | 2.13% | ||
| 12 | PERCEPTIVE ADVISORS LLC | 910,872 | 35,205,000 | 2.03% | ||
| 13 | Rock Springs Capital Management LP | 910,250 | 35,181,000 | 2.03% | ||
| 14 | ORBIMED ADVISORS LLC | 704,100 | 27,213,000 | 1.57% | ||
| 15 | PICTET ASSET MANAGEMENT LTD | 534,539 | 20,660,000 | 1.19% | ||
| 16 | VOYA INVESTMENT MANAGEMENT LLC | 462,963 | 17,893,000 | 1.03% | ||
| 17 | Bank of New York Mellon Corp | 444,049 | 17,163,000 | 0.99% | ||
| 18 | Fiera Capital Corp | 436,626 | 16,876,000 | 0.97% | ||
| 19 | FRANKLIN RESOURCES INC | 432,600 | 16,720,000 | 0.96% | ||
| 20 | NORTHERN TRUST CORP | 371,801 | 14,370,000 | 0.83% | ||
| 21 | ALLIANCEBERNSTEIN L.P. | 363,920 | 14,066,000 | 0.81% | ||
| 22 | NORGES BANK | 355,474 | 13,739,000 | 0.79% | ||
| 23 | ROYAL BANK OF CANADA | 324,411 | 12,540,000 | 0.72% | ||
| 24 | OppenheimerFunds, Inc. | 301,631 | 11,658,000 | 0.67% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 299,263 | 11,566,000 | 0.67% | ||
| 26 | DEUTSCHE BANK AG\ | 288,277 | 11,140,000 | 0.64% | ||
| 27 | CREDIT AGRICOLE S A | 259,400 | 10,026,000 | 0.58% | ||
| 28 | BANK OF AMERICA CORP /DE/ | 258,545 | 9,993,000 | 0.58% | ||
| 29 | Artal Group S.A. | 250,000 | 9,663,000 | 0.56% | ||
| 30 | PEREGRINE CAPITAL MANAGEMENT INC /MN/ | 223,773 | 8,741,000 | 0.50% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 221,000 | 8,542,000 | 0.49% | Call | |
| 32 | FOLGER HILL ASSET MANAGEMENT LP | 210,201 | 8,124,000 | 0.47% | ||
| 33 | GOLDMAN SACHS GROUP INC | 207,873 | 8,034,000 | 0.46% | ||
| 34 | WELLS FARGO & COMPANY/MN | 192,221 | 7,430,000 | 0.43% | ||
| 35 | OXFORD ASSET MANAGEMENT LLP | 185,000 | 7,150,000 | 0.41% | ||
| 36 | JPMORGAN CHASE & CO | 179,334 | 6,931,000 | 0.40% | ||
| 37 | JANA PARTNERS LLC | 168,992 | 6,532,000 | 0.38% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 168,500 | 6,513,000 | 0.38% | Put | |
| 39 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 148,921 | 5,756,000 | 0.33% | ||
| 40 | GOLDMAN SACHS GROUP INC | 107,500 | 4,155,000 | 0.24% | Call | |
| 41 | NOMURA HOLDINGS INC | 100,000 | 3,871,000 | 0.22% | Call | |
| 42 | NOMURA HOLDINGS INC | 100,000 | 3,871,000 | 0.22% | Put | |
| 43 | Laurion Capital Management LP | 100,000 | 3,865,000 | 0.22% | Put | |
| 44 | Laurion Capital Management LP | 100,000 | 3,865,000 | 0.22% | Call | |
| 45 | CREDIT SUISSE AG/ | 92,180 | 3,563,000 | 0.21% | ||
| 46 | NEW YORK STATE COMMON RETIREMENT FUND | 88,883 | 3,435,000 | 0.20% | ||
| 47 | TD ASSET MANAGEMENT INC | 86,870 | 3,358,000 | 0.19% | ||
| 48 | TIAA CREF INVESTMENT MANAGEMENT LLC | 85,730 | 3,313,000 | 0.19% | ||
| 49 | MORGAN STANLEY | 79,947 | 3,090,000 | 0.18% | ||
| 50 | SCHONFELD STRATEGIC ADVISORS LLC | 77,723 | 3,005,000 | 0.17% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
