| 1 |
VHCP Management, LLC |
703,730 |
5,376,000 |
16.12% |
|
|
| 2 |
QVT Financial LP |
694,227 |
5,062,000 |
15.18% |
|
|
| 3 |
MILLENNIUM MANAGEMENT LLC |
495,388 |
3,785,000 |
11.35% |
|
|
| 4 |
RA CAPITAL MANAGEMENT, L.P. |
490,697 |
3,749,000 |
11.24% |
|
|
| 5 |
GREAT POINT PARTNERS LLC |
296,944 |
2,269,000 |
6.80% |
|
|
| 6 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
261,119 |
1,995,000 |
5.98% |
|
|
| 7 |
JENNISON ASSOCIATES LLC |
238,152 |
1,819,000 |
5.45% |
|
|
| 8 |
VANGUARD GROUP INC |
207,311 |
1,584,000 |
4.75% |
|
|
| 9 |
DAFNA Capital Management LLC |
160,622 |
1,227,000 |
3.68% |
|
|
| 10 |
SABBY MANAGEMENT, LLC |
151,358 |
1,156,000 |
3.47% |
|
|
| 11 |
PACIFIC ALTERNATIVE ASSET MANAGEMENT COMPANY, LLC |
133,789 |
1,022,000 |
3.06% |
|
|
| 12 |
SPHERA FUNDS MANAGEMENT LTD. |
127,048 |
971,000 |
2.91% |
|
|
| 13 |
Ghost Tree Capital, LLC |
100,000 |
764,000 |
2.29% |
|
|
| 14 |
RENAISSANCE TECHNOLOGIES LLC |
63,749 |
487,000 |
1.46% |
|
|
| 15 |
FMR LLC |
58,000 |
443,000 |
1.33% |
|
|
| 16 |
PRICE T ROWE ASSOCIATES INC /MD/ |
32,442 |
248,000 |
0.74% |
|
|
| 17 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
30,711 |
235,000 |
0.70% |
|
|
| 18 |
BlackRock Fund Advisors |
26,781 |
205,000 |
0.61% |
|
|
| 19 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
24,460 |
187,000 |
0.56% |
|
|
| 20 |
Bank of New York Mellon Corp |
21,703 |
166,000 |
0.50% |
|
|
| 21 |
MORGAN STANLEY |
18,309 |
140,000 |
0.42% |
|
|
| 22 |
TURNER INVESTMENTS LLC |
17,820 |
136,000 |
0.41% |
|
|
| 23 |
GLENMEDE TRUST CO NA |
11,352 |
86,000 |
0.26% |
|
|
| 24 |
KMS FINANCIAL SERVICES, INC |
10,000 |
76,000 |
0.23% |
|
|
| 25 |
Weiss Multi-Strategy Advisers LLC |
10,000 |
76,000 |
0.23% |
|
|
| 26 |
BANK OF AMERICA CORP /DE/ |
4,700 |
36,000 |
0.11% |
|
|
| 27 |
BlackRock Investment Management, LLC |
1,662 |
13,000 |
0.04% |
|
|
| 28 |
BANK OF MONTREAL /CAN/ |
1,300 |
10,000 |
0.03% |
|
|
| 29 |
Tower Research Capital LLC (TRC) |
1,028 |
8,000 |
0.02% |
|
|
| 30 |
CITIGROUP INC |
1,000 |
8,000 |
0.02% |
|
|
| 31 |
WELLS FARGO & COMPANY/MN |
925 |
7,000 |
0.02% |
|
|
| 32 |
BARCLAYS PLC |
200 |
1,000 |
0.00% |
|
|
| 33 |
ROYAL BANK OF CANADA |
2 |
0 |
0.00% |
|
|
