| 1 |
GREAT POINT PARTNERS LLC |
1,963,777 |
4,124,000 |
21.45% |
|
|
| 2 |
INTERWEST VENTURE MANAGEMENT CO |
1,248,064 |
2,621,000 |
13.63% |
|
|
| 3 |
VHCP MANAGEMENT II, LLC |
1,217,872 |
2,558,000 |
13.30% |
|
|
| 4 |
VHCP Management, LLC |
912,050 |
1,915,000 |
9.96% |
|
|
| 5 |
QVT Financial LP |
906,286 |
1,903,000 |
9.90% |
|
|
| 6 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
572,893 |
1,203,000 |
6.26% |
|
|
| 7 |
SABBY MANAGEMENT, LLC |
328,632 |
690,000 |
3.59% |
|
|
| 8 |
MILLENNIUM MANAGEMENT LLC |
320,000 |
672,000 |
3.49% |
|
|
| 9 |
PURA VIDA INVESTMENTS, LLC |
258,893 |
544,000 |
2.83% |
|
|
| 10 |
Endurant Capital Management LP |
226,442 |
476,000 |
2.48% |
|
|
| 11 |
RENAISSANCE TECHNOLOGIES LLC |
219,100 |
460,000 |
2.39% |
|
|
| 12 |
VANGUARD GROUP INC |
173,793 |
365,000 |
1.90% |
|
|
| 13 |
VIVO CAPITAL, LLC |
153,331 |
322,000 |
1.67% |
|
|
| 14 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
131,060 |
275,000 |
1.43% |
|
|
| 15 |
Weiss Multi-Strategy Advisers LLC |
110,000 |
231,000 |
1.20% |
|
|
| 16 |
GEODE CAPITAL MANAGEMENT, LLC |
61,088 |
128,000 |
0.67% |
|
|
| 17 |
BlackRock Fund Advisors |
56,990 |
120,000 |
0.62% |
|
|
| 18 |
Virtu KCG Holdings LLC |
43,045 |
90,000 |
0.47% |
|
|
| 19 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
34,751 |
73,000 |
0.38% |
|
|
| 20 |
STIFEL FINANCIAL CORP |
34,261 |
71,000 |
0.37% |
|
|
| 21 |
Bank of New York Mellon Corp |
31,880 |
67,000 |
0.35% |
|
|
| 22 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
30,711 |
64,000 |
0.33% |
|
|
| 23 |
GLENMEDE TRUST CO NA |
28,200 |
59,000 |
0.31% |
|
|
| 24 |
GOLDMAN SACHS GROUP INC |
20,193 |
42,000 |
0.22% |
|
|
| 25 |
DIMENSIONAL FUND ADVISORS LP |
15,648 |
33,000 |
0.17% |
|
|
| 26 |
ROYAL BANK OF CANADA |
13,244 |
28,000 |
0.15% |
|
|
| 27 |
NORTHERN TRUST CORP |
13,318 |
28,000 |
0.15% |
|
|
| 28 |
IPG Investment Advisors LLC |
13,000 |
27,300 |
0.14% |
|
|
| 29 |
PANAGORA ASSET MANAGEMENT INC |
8,899 |
19,000 |
0.10% |
|
|
| 30 |
BlackRock Investment Management, LLC |
2,764 |
6,000 |
0.03% |
|
|
| 31 |
MORGAN STANLEY |
2,288 |
5,000 |
0.03% |
|
|
| 32 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
1,755 |
4,000 |
0.02% |
|
|
| 33 |
Creative Planning |
1,500 |
3,000 |
0.02% |
|
|
| 34 |
INDEPENDENT ADVISOR ALLIANCE |
1,000 |
2,100 |
0.01% |
|
|
| 35 |
Tower Research Capital LLC (TRC) |
700 |
1,000 |
0.01% |
|
|
| 36 |
ACROSPIRE INVESTMENT MANAGEMENT LLC |
700 |
1,000 |
0.01% |
|
|
| 37 |
REILLY FINANCIAL ADVISORS, LLC |
200 |
0 |
0.00% |
|
|
