| 1 |
GREAT POINT PARTNERS LLC |
1,963,777 |
6,127,000 |
27.27% |
|
|
| 2 |
QVT Financial LP |
932,086 |
2,908,000 |
12.94% |
|
|
| 3 |
VHCP Management, LLC |
703,730 |
2,196,000 |
9.78% |
|
|
| 4 |
TURNER INVESTMENTS LLC |
673,487 |
2,101,000 |
9.35% |
|
|
| 5 |
SPHERA FUNDS MANAGEMENT LTD. |
550,000 |
1,716,000 |
7.64% |
|
|
| 6 |
MILLENNIUM MANAGEMENT LLC |
533,794 |
1,665,000 |
7.41% |
|
|
| 7 |
SABBY MANAGEMENT, LLC |
385,300 |
1,202,000 |
5.35% |
|
|
| 8 |
VANGUARD GROUP INC |
381,225 |
1,189,000 |
5.29% |
|
|
| 9 |
Weiss Multi-Strategy Advisers LLC |
197,000 |
615,000 |
2.74% |
|
|
| 10 |
Endurant Capital Management LP |
137,093 |
428,000 |
1.91% |
|
|
| 11 |
PURA VIDA INVESTMENTS, LLC |
131,000 |
409,000 |
1.82% |
|
|
| 12 |
Ghost Tree Capital, LLC |
125,000 |
390,000 |
1.74% |
|
|
| 13 |
RENAISSANCE TECHNOLOGIES LLC |
105,100 |
328,000 |
1.46% |
|
|
| 14 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
83,060 |
259,000 |
1.15% |
|
|
| 15 |
GEODE CAPITAL MANAGEMENT, LLC |
60,728 |
189,000 |
0.84% |
|
|
| 16 |
Bank of New York Mellon Corp |
37,910 |
119,000 |
0.53% |
|
|
| 17 |
BlackRock Fund Advisors |
35,633 |
111,000 |
0.49% |
|
|
| 18 |
STIFEL FINANCIAL CORP |
33,040 |
103,000 |
0.46% |
|
|
| 19 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
30,711 |
96,000 |
0.43% |
|
|
| 20 |
CITADEL ADVISORS LLC |
18,932 |
59,000 |
0.26% |
|
|
| 21 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
16,100 |
50,000 |
0.22% |
Call |
|
| 22 |
DIMENSIONAL FUND ADVISORS LP |
15,648 |
49,000 |
0.22% |
|
|
| 23 |
Quantitative Systematic Strategies LLC |
13,548 |
42,000 |
0.19% |
|
|
| 24 |
NORTHERN TRUST CORP |
12,786 |
40,000 |
0.18% |
|
|
| 25 |
GLENMEDE TRUST CO NA |
11,352 |
35,000 |
0.16% |
|
|
| 26 |
GROUP ONE TRADING LLC |
5,500 |
17,000 |
0.08% |
|
|
| 27 |
Tower Research Capital LLC (TRC) |
2,942 |
9,000 |
0.04% |
|
|
| 28 |
BlackRock Investment Management, LLC |
2,386 |
7,000 |
0.03% |
|
|
| 29 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
1,755 |
5,000 |
0.02% |
|
|
| 30 |
DEUTSCHE BANK AG\ |
449 |
1,000 |
0.00% |
|
|
