| 1 |
GREAT POINT PARTNERS LLC |
1,963,777 |
5,774,000 |
25.08% |
|
|
| 2 |
VHCP MANAGEMENT II, LLC |
948,372 |
2,788,000 |
12.11% |
|
|
| 3 |
QVT Financial LP |
932,086 |
2,447,000 |
10.63% |
|
|
| 4 |
VHCP Management, LLC |
796,550 |
2,342,000 |
10.17% |
|
|
| 5 |
MILLENNIUM MANAGEMENT LLC |
531,131 |
1,562,000 |
6.78% |
|
|
| 6 |
TURNER INVESTMENTS LLC |
450,000 |
1,323,000 |
5.75% |
|
|
| 7 |
VANGUARD GROUP INC |
403,935 |
1,188,000 |
5.16% |
|
|
| 8 |
SABBY MANAGEMENT, LLC |
399,035 |
1,173,000 |
5.10% |
|
|
| 9 |
Weiss Multi-Strategy Advisers LLC |
197,000 |
579,000 |
2.51% |
|
|
| 10 |
SPHERA FUNDS MANAGEMENT LTD. |
186,800 |
549,000 |
2.38% |
|
|
| 11 |
VIVO CAPITAL, LLC |
153,331 |
451,000 |
1.96% |
|
|
| 12 |
RENAISSANCE TECHNOLOGIES LLC |
146,400 |
430,000 |
1.87% |
|
|
| 13 |
Endurant Capital Management LP |
137,093 |
403,000 |
1.75% |
|
|
| 14 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
135,860 |
399,000 |
1.73% |
|
|
| 15 |
PURA VIDA INVESTMENTS, LLC |
131,000 |
385,000 |
1.67% |
|
|
| 16 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
75,293 |
221,000 |
0.96% |
|
|
| 17 |
GEODE CAPITAL MANAGEMENT, LLC |
60,638 |
178,000 |
0.77% |
|
|
| 18 |
Ghost Tree Capital, LLC |
45,000 |
132,000 |
0.57% |
|
|
| 19 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
38,700 |
114,000 |
0.50% |
Call |
|
| 20 |
Bank of New York Mellon Corp |
37,910 |
112,000 |
0.49% |
|
|
| 21 |
BlackRock Fund Advisors |
33,290 |
98,000 |
0.43% |
|
|
| 22 |
STIFEL FINANCIAL CORP |
32,715 |
96,000 |
0.42% |
|
|
| 23 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
30,711 |
90,000 |
0.39% |
|
|
| 24 |
DIMENSIONAL FUND ADVISORS LP |
15,648 |
46,000 |
0.20% |
|
|
| 25 |
NORTHERN TRUST CORP |
13,186 |
39,000 |
0.17% |
|
|
| 26 |
Virtu KCG Holdings LLC |
13,382 |
39,000 |
0.17% |
|
|
| 27 |
GLENMEDE TRUST CO NA |
11,352 |
33,000 |
0.14% |
|
|
| 28 |
GROUP ONE TRADING LLC |
4,154 |
12,000 |
0.05% |
|
|
| 29 |
BlackRock Investment Management, LLC |
2,386 |
7,000 |
0.03% |
|
|
| 30 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
1,755 |
5,000 |
0.02% |
|
|
| 31 |
MORGAN STANLEY |
1,317 |
4,000 |
0.02% |
|
|
| 32 |
Tower Research Capital LLC (TRC) |
511 |
2,000 |
0.01% |
|
|
| 33 |
Walleye Trading LLC |
200 |
1,000 |
0.00% |
|
|
| 34 |
DEUTSCHE BANK AG\ |
82 |
0 |
0.00% |
|
|
