| 1 |
GREAT POINT PARTNERS LLC |
1,963,777 |
3,731,000 |
25.42% |
|
|
| 2 |
VHCP MANAGEMENT II, LLC |
948,372 |
1,802,000 |
12.28% |
|
|
| 3 |
VHCP Management, LLC |
796,550 |
1,513,000 |
10.31% |
|
|
| 4 |
QVT Financial LP |
932,086 |
1,488,000 |
10.14% |
|
|
| 5 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
572,893 |
1,088,000 |
7.41% |
|
|
| 6 |
MILLENNIUM MANAGEMENT LLC |
516,343 |
981,000 |
6.68% |
|
|
| 7 |
SABBY MANAGEMENT, LLC |
424,035 |
806,000 |
5.49% |
|
|
| 8 |
VANGUARD GROUP INC |
408,835 |
777,000 |
5.29% |
|
|
| 9 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
210,860 |
401,000 |
2.73% |
|
|
| 10 |
RENAISSANCE TECHNOLOGIES LLC |
169,100 |
321,000 |
2.19% |
|
|
| 11 |
VIVO CAPITAL, LLC |
153,331 |
291,000 |
1.98% |
|
|
| 12 |
TURNER INVESTMENTS LLC |
139,716 |
265,000 |
1.81% |
|
|
| 13 |
PURA VIDA INVESTMENTS, LLC |
131,000 |
249,000 |
1.70% |
|
|
| 14 |
Weiss Multi-Strategy Advisers LLC |
112,995 |
215,000 |
1.47% |
|
|
| 15 |
Endurant Capital Management LP |
103,142 |
196,000 |
1.34% |
|
|
| 16 |
GEODE CAPITAL MANAGEMENT, LLC |
60,638 |
115,000 |
0.78% |
|
|
| 17 |
BlackRock Fund Advisors |
46,236 |
88,000 |
0.60% |
|
|
| 18 |
Ghost Tree Capital, LLC |
35,801 |
68,000 |
0.46% |
|
|
| 19 |
Bank of New York Mellon Corp |
34,136 |
65,000 |
0.44% |
|
|
| 20 |
STIFEL FINANCIAL CORP |
32,548 |
62,000 |
0.42% |
|
|
| 21 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
30,711 |
58,000 |
0.40% |
|
|
| 22 |
DIMENSIONAL FUND ADVISORS LP |
15,648 |
30,000 |
0.20% |
|
|
| 23 |
NORTHERN TRUST CORP |
12,786 |
24,000 |
0.16% |
|
|
| 24 |
GLENMEDE TRUST CO NA |
11,352 |
21,000 |
0.14% |
|
|
| 25 |
ROYAL BANK OF CANADA |
3,293 |
6,000 |
0.04% |
|
|
| 26 |
BlackRock Investment Management, LLC |
2,386 |
5,000 |
0.03% |
|
|
| 27 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
1,755 |
3,000 |
0.02% |
|
|
| 28 |
MORGAN STANLEY |
1,317 |
3,000 |
0.02% |
|
|
| 29 |
UBS Group AG |
1,040 |
2,000 |
0.01% |
|
|
| 30 |
Tower Research Capital LLC (TRC) |
343 |
1,000 |
0.01% |
|
|
| 31 |
WOLVERINE TRADING LP /BD |
14 |
27 |
0.00% |
|
|
| 32 |
BANK OF AMERICA CORP /DE/ |
137 |
0 |
0.00% |
|
|
| 33 |
DEUTSCHE BANK AG\ |
82 |
0 |
0.00% |
|
|
| 34 |
Walleye Trading LLC |
100 |
0 |
0.00% |
|
|
