| 1 |
GREAT POINT PARTNERS LLC |
1,859,315 |
9,111,000 |
26.49% |
|
|
| 2 |
VHCP Management, LLC |
703,730 |
3,448,000 |
10.03% |
|
|
| 3 |
DAFNA Capital Management LLC |
675,650 |
3,311,000 |
9.63% |
|
SH |
| 4 |
QVT Financial LP |
670,127 |
3,222,000 |
9.37% |
|
|
| 5 |
MILLENNIUM MANAGEMENT LLC |
487,314 |
2,388,000 |
6.94% |
|
|
| 6 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
461,119 |
2,259,000 |
6.57% |
|
|
| 7 |
RA CAPITAL MANAGEMENT, L.P. |
417,476 |
2,046,000 |
5.95% |
|
|
| 8 |
SPHERA FUNDS MANAGEMENT LTD. |
321,254 |
1,574,000 |
4.58% |
|
|
| 9 |
VANGUARD GROUP INC |
292,836 |
1,435,000 |
4.17% |
|
|
| 10 |
PACIFIC ALTERNATIVE ASSET MANAGEMENT COMPANY, LLC |
223,520 |
1,095,000 |
3.18% |
|
|
| 11 |
Weiss Multi-Strategy Advisers LLC |
210,000 |
1,029,000 |
2.99% |
|
|
| 12 |
TURNER INVESTMENTS LLC |
208,550 |
1,022,000 |
2.97% |
|
|
| 13 |
Ghost Tree Capital, LLC |
125,000 |
613,000 |
1.78% |
|
|
| 14 |
WESTFIELD CAPITAL MANAGEMENT CO LP |
65,282 |
320,000 |
0.93% |
|
|
| 15 |
FMR LLC |
58,000 |
284,000 |
0.83% |
|
|
| 16 |
AlphaOne Investment Services, LLC |
48,159 |
236,000 |
0.69% |
|
|
| 17 |
RENAISSANCE TECHNOLOGIES LLC |
38,149 |
187,000 |
0.54% |
|
|
| 18 |
PRICE T ROWE ASSOCIATES INC /MD/ |
32,442 |
159,000 |
0.46% |
|
|
| 19 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
30,711 |
150,000 |
0.44% |
|
|
| 20 |
BlackRock Fund Advisors |
24,962 |
122,000 |
0.35% |
|
|
| 21 |
Bank of New York Mellon Corp |
21,703 |
106,000 |
0.31% |
|
|
| 22 |
KMS FINANCIAL SERVICES, INC |
20,250 |
99,000 |
0.29% |
|
|
| 23 |
GEODE CAPITAL MANAGEMENT, LLC |
11,661 |
57,000 |
0.17% |
|
|
| 24 |
GLENMEDE TRUST CO NA |
11,352 |
55,000 |
0.16% |
|
|
| 25 |
BANK OF AMERICA CORP /DE/ |
7,500 |
37,000 |
0.11% |
|
|
| 26 |
BlackRock Investment Management, LLC |
2,122 |
10,000 |
0.03% |
|
|
| 27 |
CITIGROUP INC |
1,000 |
5,000 |
0.01% |
|
|
| 28 |
WELLS FARGO & COMPANY/MN |
925 |
4,000 |
0.01% |
|
|
| 29 |
Tower Research Capital LLC (TRC) |
309 |
2,000 |
0.01% |
|
|
| 30 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
166 |
1,000 |
0.00% |
|
|
| 31 |
Ground Swell Capital, LLC |
200 |
1,000 |
0.00% |
|
|
