| 1 |
GREAT POINT PARTNERS LLC |
1,963,777 |
6,206,000 |
28.86% |
|
|
| 2 |
QVT Financial LP |
752,578 |
2,319,000 |
10.79% |
|
|
| 3 |
VHCP Management, LLC |
703,730 |
2,224,000 |
10.34% |
|
|
| 4 |
MILLENNIUM MANAGEMENT LLC |
549,045 |
1,735,000 |
8.07% |
|
|
| 5 |
TURNER INVESTMENTS LLC |
521,277 |
1,647,000 |
7.66% |
|
|
| 6 |
SPHERA FUNDS MANAGEMENT LTD. |
500,000 |
1,580,000 |
7.35% |
|
|
| 7 |
SABBY MANAGEMENT, LLC |
426,544 |
1,348,000 |
6.27% |
|
|
| 8 |
VANGUARD GROUP INC |
368,322 |
1,164,000 |
5.41% |
|
|
| 9 |
Weiss Multi-Strategy Advisers LLC |
197,429 |
624,000 |
2.90% |
|
|
| 10 |
Endurant Capital Management LP |
177,121 |
560,000 |
2.60% |
|
|
| 11 |
PURA VIDA INVESTMENTS, LLC |
131,000 |
414,000 |
1.93% |
|
|
| 12 |
Ghost Tree Capital, LLC |
125,000 |
395,000 |
1.84% |
|
|
| 13 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
83,060 |
262,000 |
1.22% |
|
|
| 14 |
GEODE CAPITAL MANAGEMENT, LLC |
60,548 |
191,000 |
0.89% |
|
|
| 15 |
RENAISSANCE TECHNOLOGIES LLC |
58,200 |
184,000 |
0.86% |
|
|
| 16 |
STIFEL FINANCIAL CORP |
35,040 |
111,000 |
0.52% |
|
|
| 17 |
BlackRock Fund Advisors |
34,577 |
109,000 |
0.51% |
|
|
| 18 |
Bank of New York Mellon Corp |
34,136 |
108,000 |
0.50% |
|
|
| 19 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
30,711 |
97,000 |
0.45% |
|
|
| 20 |
Numeric Investors LLC |
18,600 |
59,000 |
0.27% |
|
|
| 21 |
NORTHERN TRUST CORP |
12,786 |
40,000 |
0.19% |
|
|
| 22 |
DIMENSIONAL FUND ADVISORS LP |
12,541 |
40,000 |
0.19% |
|
|
| 23 |
GLENMEDE TRUST CO NA |
11,352 |
35,000 |
0.16% |
|
|
| 24 |
DEUTSCHE BANK AG\ |
10,710 |
33,000 |
0.15% |
|
|
| 25 |
BlackRock Investment Management, LLC |
2,122 |
7,000 |
0.03% |
|
|
| 26 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
1,755 |
6,000 |
0.03% |
|
|
| 27 |
WELLS FARGO & COMPANY/MN |
1,325 |
4,000 |
0.02% |
|
|
