| 1 |
GREAT POINT PARTNERS LLC |
1,963,778 |
12,509,000 |
25.68% |
|
|
| 2 |
VHCP Management, LLC |
703,730 |
4,483,000 |
9.20% |
|
|
| 3 |
DAFNA Capital Management LLC |
634,893 |
4,044,000 |
8.30% |
|
|
| 4 |
QVT Financial LP |
611,627 |
3,815,000 |
7.83% |
|
|
| 5 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
461,119 |
2,937,000 |
6.03% |
|
|
| 6 |
SABBY MANAGEMENT, LLC |
429,945 |
2,739,000 |
5.62% |
|
|
| 7 |
MILLENNIUM MANAGEMENT LLC |
430,038 |
2,739,000 |
5.62% |
|
|
| 8 |
SPHERA FUNDS MANAGEMENT LTD. |
421,254 |
2,683,000 |
5.51% |
|
|
| 9 |
RA CAPITAL MANAGEMENT, L.P. |
417,476 |
2,659,000 |
5.46% |
|
|
| 10 |
VANGUARD GROUP INC |
289,484 |
1,844,000 |
3.79% |
|
|
| 11 |
Endurant Capital Management LP |
210,279 |
1,339,000 |
2.75% |
|
|
| 12 |
Weiss Multi-Strategy Advisers LLC |
210,000 |
1,338,000 |
2.75% |
|
|
| 13 |
Ghost Tree Capital, LLC |
125,000 |
796,000 |
1.63% |
|
|
| 14 |
Opus Point Partners Management, LLC |
122,673 |
781,000 |
1.60% |
|
|
| 15 |
PURA VIDA INVESTMENTS, LLC |
75,000 |
478,000 |
0.98% |
|
|
| 16 |
WESTFIELD CAPITAL MANAGEMENT CO LP |
65,282 |
416,000 |
0.85% |
|
|
| 17 |
JPMORGAN CHASE & CO |
62,351 |
397,000 |
0.82% |
|
|
| 18 |
TURNER INVESTMENTS LLC |
62,010 |
395,000 |
0.81% |
|
|
| 19 |
FMR LLC |
58,000 |
369,000 |
0.76% |
|
|
| 20 |
AlphaOne Investment Services, LLC |
42,459 |
270,000 |
0.55% |
|
|
| 21 |
PRICE T ROWE ASSOCIATES INC /MD/ |
31,942 |
203,000 |
0.42% |
|
|
| 22 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
30,711 |
196,000 |
0.40% |
|
|
| 23 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
28,260 |
180,000 |
0.37% |
|
|
| 24 |
BlackRock Fund Advisors |
26,888 |
171,000 |
0.35% |
|
|
| 25 |
Bank of New York Mellon Corp |
25,296 |
161,000 |
0.33% |
|
|
| 26 |
CREDIT SUISSE AG/ |
18,671 |
119,000 |
0.24% |
|
|
| 27 |
DEUTSCHE BANK AG\ |
15,134 |
96,000 |
0.20% |
|
|
| 28 |
STIFEL FINANCIAL CORP |
14,664 |
93,000 |
0.19% |
|
|
| 29 |
RENAISSANCE TECHNOLOGIES LLC |
12,549 |
80,000 |
0.16% |
|
|
| 30 |
GEODE CAPITAL MANAGEMENT, LLC |
12,479 |
79,000 |
0.16% |
|
|
| 31 |
GLENMEDE TRUST CO NA |
11,352 |
72,000 |
0.15% |
|
|
| 32 |
NORTHERN TRUST CORP |
10,833 |
69,000 |
0.14% |
|
|
| 33 |
BANK OF MONTREAL /CAN/ |
10,000 |
64,000 |
0.13% |
|
|
| 34 |
MORGAN STANLEY |
3,548 |
23,000 |
0.05% |
|
|
| 35 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
2,750 |
18,000 |
0.04% |
|
|
| 36 |
BlackRock Investment Management, LLC |
2,122 |
14,000 |
0.03% |
|
|
| 37 |
WELLS FARGO & COMPANY/MN |
1,925 |
12,000 |
0.02% |
|
|
| 38 |
FNY Managed Accounts LLC |
1,500 |
9,555 |
0.02% |
|
|
| 39 |
NATIONAL PLANNING CORP |
1,000 |
7,040 |
0.01% |
|
|
| 40 |
CITIGROUP INC |
1,107 |
7,000 |
0.01% |
|
|
| 41 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
235 |
2,000 |
0.00% |
|
|
