| 1 |
GREAT POINT PARTNERS LLC |
1,963,777 |
5,184,000 |
24.39% |
|
|
| 2 |
VHCP MANAGEMENT II, LLC |
1,088,372 |
2,873,000 |
13.52% |
|
|
| 3 |
QVT Financial LP |
932,086 |
2,335,000 |
10.98% |
|
|
| 4 |
VHCP Management, LLC |
856,550 |
2,261,000 |
10.64% |
|
|
| 5 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
572,893 |
1,512,000 |
7.11% |
|
|
| 6 |
MILLENNIUM MANAGEMENT LLC |
516,343 |
1,363,000 |
6.41% |
|
|
| 7 |
VANGUARD GROUP INC |
430,624 |
1,141,000 |
5.37% |
|
|
| 8 |
SABBY MANAGEMENT, LLC |
400,035 |
1,060,000 |
4.99% |
|
|
| 9 |
PURA VIDA INVESTMENTS, LLC |
248,962 |
657,000 |
3.09% |
|
|
| 10 |
RENAISSANCE TECHNOLOGIES LLC |
185,800 |
491,000 |
2.31% |
|
|
| 11 |
VIVO CAPITAL, LLC |
153,331 |
405,000 |
1.91% |
|
|
| 12 |
TURNER INVESTMENTS LLC |
134,419 |
355,000 |
1.67% |
|
|
| 13 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
131,060 |
347,000 |
1.63% |
|
|
| 14 |
Weiss Multi-Strategy Advisers LLC |
110,000 |
290,000 |
1.36% |
|
|
| 15 |
Endurant Capital Management LP |
103,142 |
272,000 |
1.28% |
|
|
| 16 |
GEODE CAPITAL MANAGEMENT, LLC |
60,728 |
160,000 |
0.75% |
|
|
| 17 |
BlackRock Fund Advisors |
53,850 |
142,000 |
0.67% |
|
|
| 18 |
STIFEL FINANCIAL CORP |
32,548 |
88,000 |
0.41% |
|
|
| 19 |
Bank of New York Mellon Corp |
32,464 |
85,000 |
0.40% |
|
|
| 20 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
30,711 |
81,000 |
0.38% |
|
|
| 21 |
DIMENSIONAL FUND ADVISORS LP |
15,648 |
41,000 |
0.19% |
|
|
| 22 |
NORTHERN TRUST CORP |
12,786 |
34,000 |
0.16% |
|
|
| 23 |
GLENMEDE TRUST CO NA |
11,352 |
29,000 |
0.14% |
|
|
| 24 |
PANAGORA ASSET MANAGEMENT INC |
8,899 |
24,000 |
0.11% |
|
|
| 25 |
ROYAL BANK OF CANADA |
3,244 |
9,000 |
0.04% |
|
|
| 26 |
BlackRock Investment Management, LLC |
2,764 |
7,000 |
0.03% |
|
|
| 27 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
1,755 |
5,000 |
0.02% |
|
|
| 28 |
MORGAN STANLEY |
1,317 |
3,000 |
0.01% |
|
|
| 29 |
Tower Research Capital LLC (TRC) |
400 |
1,000 |
0.00% |
|
|
| 30 |
BANK OF AMERICA CORP /DE/ |
495 |
1,000 |
0.00% |
|
|
| 31 |
JPMORGAN CHASE & CO |
400 |
1,000 |
0.00% |
|
|
