| 1 |
GREAT POINT PARTNERS LLC |
1,963,777 |
9,249,000 |
30.16% |
|
|
| 2 |
VHCP Management, LLC |
703,730 |
3,315,000 |
10.81% |
|
|
| 3 |
QVT Financial LP |
590,127 |
2,779,000 |
9.06% |
|
|
| 4 |
MILLENNIUM MANAGEMENT LLC |
534,466 |
2,517,000 |
8.21% |
|
|
| 5 |
RA CAPITAL MANAGEMENT, L.P. |
417,476 |
1,966,000 |
6.41% |
|
|
| 6 |
SABBY MANAGEMENT, LLC |
354,574 |
1,670,000 |
5.44% |
|
|
| 7 |
VANGUARD GROUP INC |
344,293 |
1,621,000 |
5.29% |
|
|
| 8 |
SPHERA FUNDS MANAGEMENT LTD. |
321,254 |
1,513,000 |
4.93% |
|
|
| 9 |
Weiss Multi-Strategy Advisers LLC |
195,000 |
918,000 |
2.99% |
|
|
| 10 |
Opus Point Partners Management, LLC |
182,673 |
860,000 |
2.80% |
|
|
| 11 |
Endurant Capital Management LP |
159,202 |
750,000 |
2.45% |
|
|
| 12 |
Ghost Tree Capital, LLC |
125,000 |
589,000 |
1.92% |
|
|
| 13 |
WESTFIELD CAPITAL MANAGEMENT CO LP |
85,982 |
405,000 |
1.32% |
|
|
| 14 |
PURA VIDA INVESTMENTS, LLC |
75,000 |
353,000 |
1.15% |
|
|
| 15 |
TURNER INVESTMENTS LLC |
66,940 |
315,000 |
1.03% |
|
|
| 16 |
FMR LLC |
58,000 |
273,000 |
0.89% |
|
|
| 17 |
GEODE CAPITAL MANAGEMENT, LLC |
48,857 |
230,000 |
0.75% |
|
|
| 18 |
JPMORGAN CHASE & CO |
48,534 |
229,000 |
0.75% |
|
|
| 19 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
43,560 |
205,000 |
0.67% |
|
|
| 20 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
30,711 |
196,000 |
0.64% |
|
|
| 21 |
Bank of New York Mellon Corp |
35,119 |
165,000 |
0.54% |
|
|
| 22 |
STIFEL FINANCIAL CORP |
33,839 |
159,000 |
0.52% |
|
|
| 23 |
BlackRock Fund Advisors |
31,225 |
147,000 |
0.48% |
|
|
| 24 |
DIMENSIONAL FUND ADVISORS LP |
12,100 |
57,000 |
0.19% |
|
|
| 25 |
GLENMEDE TRUST CO NA |
11,352 |
53,000 |
0.17% |
|
|
| 26 |
NORTHERN TRUST CORP |
10,833 |
51,000 |
0.17% |
|
|
| 27 |
BANK OF MONTREAL /CAN/ |
7,000 |
33,000 |
0.11% |
|
|
| 28 |
DEUTSCHE BANK AG\ |
5,742 |
25,000 |
0.08% |
|
|
| 29 |
BlackRock Investment Management, LLC |
2,122 |
10,000 |
0.03% |
|
|
| 30 |
WELLS FARGO & COMPANY/MN |
1,925 |
9,000 |
0.03% |
|
|
| 31 |
CITIGROUP INC |
1,380 |
7,000 |
0.02% |
|
|
| 32 |
Tower Research Capital LLC (TRC) |
263 |
1,000 |
0.00% |
|
|
| 33 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
235 |
1,000 |
0.00% |
|
|
| 34 |
MORGAN STANLEY |
33 |
0 |
0.00% |
|
|
