| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | SECTORAL ASSET MANAGEMENT INC | 1,347,642 | 45,348,000 | 22.68% | ||
| 2 | BVF INC/IL | 989,778 | 33,306,000 | 16.65% | ||
| 3 | COLUMBUS CIRCLE INVESTORS | 696,550 | 23,439,000 | 11.72% | ||
| 4 | BlackRock Fund Advisors | 491,139 | 16,527,000 | 8.26% | ||
| 5 | PRIMECAP MANAGEMENT CO/CA/ | 340,700 | 11,465,000 | 5.73% | ||
| 6 | Alyeska Investment Group, L.P. | 261,763 | 8,808,000 | 4.40% | ||
| 7 | FRANKLIN RESOURCES INC | 236,800 | 7,968,000 | 3.98% | ||
| 8 | FMR LLC | 194,100 | 6,531,000 | 3.27% | ||
| 9 | VANGUARD GROUP INC | 150,548 | 5,066,000 | 2.53% | ||
| 10 | Cupps Capital Management, LLC | 128,853 | 4,335,000 | 2.17% | ||
| 11 | BANK OF AMERICA CORP /DE/ | 93,172 | 3,136,000 | 1.57% | ||
| 12 | PICTET ASSET MANAGEMENT LTD | 81,200 | 2,732,000 | 1.37% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 76,150 | 2,562,000 | 1.28% | ||
| 14 | Visium Asset Management, LP | 75,001 | 2,524,000 | 1.26% | ||
| 15 | STATE STREET CORP | 72,285 | 2,432,000 | 1.22% | ||
| 16 | DEUTSCHE BANK AG\ | 67,773 | 2,280,000 | 1.14% | ||
| 17 | NORTHERN TRUST CORP | 58,189 | 1,958,000 | 0.98% | ||
| 18 | EVENTIDE ASSET MANAGEMENT, LLC | 52,800 | 1,777,000 | 0.89% | ||
| 19 | WELLINGTON MANAGEMENT GROUP LLP | 50,000 | 1,682,000 | 0.84% | ||
| 20 | MORGAN STANLEY | 39,722 | 1,337,000 | 0.67% | ||
| 21 | Granite Point Capital Management, L.P. | 36,000 | 1,211,000 | 0.61% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 30,921 | 1,040,000 | 0.52% | ||
| 23 | Bank of New York Mellon Corp | 30,782 | 1,036,000 | 0.52% | ||
| 24 | MILLENNIUM MANAGEMENT LLC | 28,760 | 968,000 | 0.48% | ||
| 25 | GLENMEDE TRUST CO NA | 28,700 | 965,000 | 0.48% | ||
| 26 | ProShare Advisors LLC | 27,262 | 917,000 | 0.46% | ||
| 27 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 25,900 | 872,000 | 0.44% | ||
| 28 | FEDERATED HERMES, INC. | 24,886 | 837,000 | 0.42% | ||
| 29 | RUSSELL FRANK CO/ | 26,565 | 695,000 | 0.35% | ||
| 30 | ClariVest Asset Management LLC | 19,241 | 647,000 | 0.32% | ||
| 31 | GOLDMAN SACHS GROUP INC | 14,076 | 474,000 | 0.24% | ||
| 32 | BlackRock Investment Management, LLC | 13,507 | 455,000 | 0.23% | ||
| 33 | TCW GROUP INC | 13,034 | 439,000 | 0.22% | ||
| 34 | TIAA CREF INVESTMENT MANAGEMENT LLC | 12,680 | 427,000 | 0.21% | ||
| 35 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 12,545 | 423,000 | 0.21% | ||
| 36 | CREDIT SUISSE AG/ | 12,529 | 422,000 | 0.21% | ||
| 37 | FIRST MERCANTILE TRUST CO | 11,120 | 375,000 | 0.19% | ||
| 38 | BANK OF MONTREAL /CAN/ | 11,000 | 370,000 | 0.19% | ||
| 39 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 11,195 | 291,000 | 0.15% | ||
| 40 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 8,500 | 286,000 | 0.14% | ||
| 41 | AMERICAN INTERNATIONAL GROUP, INC. | 6,550 | 220,408 | 0.11% | ||
| 42 | TEACHERS ADVISORS, LLC | 6,407 | 216,000 | 0.11% | ||
| 43 | HAMILTON LANE ADVISORS LLC | 6,073 | 204,000 | 0.10% | ||
| 44 | BARCLAYS PLC | 5,141 | 169,000 | 0.08% | ||
| 45 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 4,309 | 145,000 | 0.07% | ||
| 46 | UBS AG | 3,810 | 128,000 | 0.06% | ||
| 47 | Nationwide Fund Advisors | 3,620 | 122,000 | 0.06% | ||
| 48 | BLACKROCK ADVISORS LLC | 3,491 | 117,000 | 0.06% | ||
| 49 | CITIGROUP INC | 2,969 | 100,000 | 0.05% | ||
| 50 | MAZAMA CAPITAL MANAGEMENT INC | 1,528 | 51,000 | 0.03% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
