| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADAMS STREET PARTNERS LLC | 1,839,730 | 14,184,000 | 11.49% | ||
| 2 | PRIMECAP MANAGEMENT CO/CA/ | 1,800,700 | 13,883,000 | 11.25% | ||
| 3 | BVF INC/IL | 1,760,489 | 13,573,000 | 11.00% | ||
| 4 | BlackRock Fund Advisors | 1,195,897 | 9,220,000 | 7.47% | ||
| 5 | FMR LLC | 1,003,138 | 7,734,000 | 6.27% | ||
| 6 | FRANKLIN RESOURCES INC | 963,700 | 7,430,000 | 6.02% | ||
| 7 | VANGUARD GROUP INC | 899,991 | 6,938,000 | 5.62% | ||
| 8 | Alyeska Investment Group, L.P. | 689,254 | 5,314,000 | 4.31% | ||
| 9 | Iguana Healthcare Management, LLC | 550,000 | 4,241,000 | 3.44% | ||
| 10 | RENAISSANCE TECHNOLOGIES LLC | 469,300 | 3,618,000 | 2.93% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 380,570 | 2,934,000 | 2.38% | ||
| 12 | STATE STREET CORP | 341,271 | 2,628,000 | 2.13% | ||
| 13 | DISCIPLINED GROWTH INVESTORS INC /MN | 326,900 | 2,520,000 | 2.04% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 315,719 | 2,434,000 | 1.97% | ||
| 15 | NORTHERN TRUST CORP | 292,494 | 2,255,000 | 1.83% | ||
| 16 | Cannell & Co. | 252,228 | 1,945,000 | 1.58% | ||
| 17 | First Eagle Investment Management, LLC | 230,400 | 1,776,000 | 1.44% | ||
| 18 | Candriam S.C.A. | 207,000 | 1,596,000 | 1.29% | ||
| 19 | EVENTIDE ASSET MANAGEMENT, LLC | 190,000 | 1,465,000 | 1.19% | ||
| 20 | NORGES BANK | 182,357 | 1,406,000 | 1.14% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 165,963 | 1,278,000 | 1.04% | ||
| 22 | BANK OF AMERICA CORP /DE/ | 140,746 | 1,085,000 | 0.88% | ||
| 23 | DEUTSCHE BANK AG\ | 127,109 | 979,000 | 0.79% | ||
| 24 | MORGAN STANLEY | 108,943 | 840,000 | 0.68% | ||
| 25 | Bank of New York Mellon Corp | 103,968 | 802,000 | 0.65% | ||
| 26 | CREDIT SUISSE AG/ | 91,946 | 709,000 | 0.57% | ||
| 27 | BlackRock Investment Management, LLC | 86,206 | 665,000 | 0.54% | ||
| 28 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 77,382 | 597,000 | 0.48% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 74,158 | 572,000 | 0.46% | ||
| 30 | Birchview Capital, LP | 70,689 | 545,000 | 0.44% | ||
| 31 | NJ State Employees Deferred Compensation Plan | 70,000 | 540,000 | 0.44% | ||
| 32 | QS Investors, LLC | 64,307 | 496,000 | 0.40% | ||
| 33 | TIAA CREF INVESTMENT MANAGEMENT LLC | 58,329 | 450,000 | 0.36% | ||
| 34 | BARCLAYS PLC | 50,000 | 386,000 | 0.31% | Call | |
| 35 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 43,733 | 337,000 | 0.27% | ||
| 36 | GOLDMAN SACHS GROUP INC | 42,872 | 331,000 | 0.27% | ||
| 37 | BARCLAYS PLC | 39,978 | 308,000 | 0.25% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 38,700 | 298,000 | 0.24% | Put | |
| 39 | TURNER INVESTMENTS LLC | 38,083 | 294,000 | 0.24% | ||
| 40 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 36,674 | 283,000 | 0.23% | ||
| 41 | ALPS ADVISORS INC | 35,645 | 275,000 | 0.22% | ||
| 42 | VIRTUS ETF ADVISERS LLC | 32,651 | 252,000 | 0.20% | ||
| 43 | TEACHERS ADVISORS, LLC | 30,423 | 235,000 | 0.19% | ||
| 44 | ProShare Advisors LLC | 27,913 | 215,000 | 0.17% | ||
| 45 | Swiss National Bank | 27,200 | 210,000 | 0.17% | ||
| 46 | SECOR Capital Advisors, LP | 26,380 | 203,000 | 0.16% | ||
| 47 | PDT Partners, LLC | 23,900 | 184,000 | 0.15% | ||
| 48 | GLENMEDE TRUST CO NA | 22,900 | 176,000 | 0.14% | ||
| 49 | ALLIANCEBERNSTEIN L.P. | 22,300 | 172,000 | 0.14% | ||
| 50 | PRICE T ROWE ASSOCIATES INC /MD/ | 20,587 | 159,000 | 0.13% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
