| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADAMS STREET PARTNERS LLC | 1,839,730 | 18,600,000 | 16.87% | ||
| 2 | BVF INC/IL | 1,339,336 | 13,541,000 | 12.28% | ||
| 3 | FMR LLC | 911,303 | 9,213,000 | 8.36% | ||
| 4 | BlackRock Fund Advisors | 823,398 | 8,325,000 | 7.55% | ||
| 5 | VANGUARD GROUP INC | 600,928 | 6,075,000 | 5.51% | ||
| 6 | Iguana Healthcare Management, LLC | 467,025 | 4,722,000 | 4.28% | ||
| 7 | Alyeska Investment Group, L.P. | 325,000 | 3,286,000 | 2.98% | ||
| 8 | DISCIPLINED GROWTH INVESTORS INC /MN | 308,950 | 3,123,000 | 2.83% | ||
| 9 | FRANKLIN RESOURCES INC | 293,900 | 2,971,000 | 2.70% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 265,174 | 2,681,000 | 2.43% | ||
| 11 | STATE STREET CORP | 236,832 | 2,396,000 | 2.17% | ||
| 12 | PRIMECAP MANAGEMENT CO/CA/ | 215,800 | 2,182,000 | 1.98% | ||
| 13 | Cannell & Co. | 210,403 | 2,127,000 | 1.93% | ||
| 14 | NORTHERN TRUST CORP | 202,907 | 2,051,000 | 1.86% | ||
| 15 | EVENTIDE ASSET MANAGEMENT, LLC | 190,000 | 1,921,000 | 1.74% | ||
| 16 | First Eagle Investment Management, LLC | 184,430 | 1,865,000 | 1.69% | ||
| 17 | NORGES BANK | 182,357 | 1,844,000 | 1.67% | ||
| 18 | BANK OF AMERICA CORP /DE/ | 133,653 | 1,351,000 | 1.23% | ||
| 19 | BARCLAYS PLC | 117,537 | 1,175,000 | 1.07% | ||
| 20 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 111,937 | 1,131,000 | 1.03% | ||
| 21 | Candriam S.C.A. | 105,000 | 1,056,000 | 0.96% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 102,089 | 1,032,000 | 0.94% | ||
| 23 | JENNISON ASSOCIATES LLC | 89,546 | 905,000 | 0.82% | ||
| 24 | Bank of New York Mellon Corp | 85,593 | 865,000 | 0.78% | ||
| 25 | CREDIT SUISSE AG/ | 82,863 | 838,000 | 0.76% | ||
| 26 | A.R.T. Advisors, LLC | 82,313 | 832,000 | 0.75% | ||
| 27 | NJ State Employees Deferred Compensation Plan | 70,000 | 784,000 | 0.71% | ||
| 28 | Birchview Capital, LP | 70,689 | 715,000 | 0.65% | ||
| 29 | QS Investors, LLC | 64,307 | 650,000 | 0.59% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 60,300 | 610,000 | 0.55% | Call | |
| 31 | BlackRock Investment Management, LLC | 59,165 | 598,000 | 0.54% | ||
| 32 | GOLDMAN SACHS GROUP INC | 56,611 | 572,000 | 0.52% | ||
| 33 | TIAA CREF INVESTMENT MANAGEMENT LLC | 53,603 | 542,000 | 0.49% | ||
| 34 | GOLDMAN SACHS GROUP INC | 50,000 | 506,000 | 0.46% | Put | |
| 35 | GOLDMAN SACHS GROUP INC | 50,000 | 506,000 | 0.46% | Call | |
| 36 | MILLENNIUM MANAGEMENT LLC | 47,356 | 479,000 | 0.43% | ||
| 37 | JPMORGAN CHASE & CO | 44,242 | 447,000 | 0.41% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 42,233 | 427,000 | 0.39% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 41,100 | 416,000 | 0.38% | Put | |
| 40 | DEUTSCHE BANK AG\ | 40,244 | 406,000 | 0.37% | ||
| 41 | PUTNAM INVESTMENTS LLC | 38,314 | 388,000 | 0.35% | ||
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 35,807 | 362,000 | 0.33% | ||
| 43 | ALPS ADVISORS INC | 33,861 | 342,000 | 0.31% | ||
| 44 | Nationwide Fund Advisors | 33,569 | 339,000 | 0.31% | ||
| 45 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 31,200 | 315,000 | 0.29% | ||
| 46 | GLENMEDE TRUST CO NA | 28,700 | 290,000 | 0.26% | ||
| 47 | TEACHERS ADVISORS, LLC | 27,462 | 278,000 | 0.25% | ||
| 48 | HANDELSBANKEN FONDER AB | 25,000 | 253,000 | 0.23% | ||
| 49 | TFS CAPITAL LLC | 24,726 | 250,000 | 0.23% | ||
| 50 | PDT Partners, LLC | 24,750 | 250,000 | 0.23% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
