| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADAMS STREET PARTNERS LLC | 1,839,730 | 41,468,000 | 16.49% | ||
| 2 | FMR LLC | 1,076,420 | 24,263,000 | 9.65% | ||
| 3 | BVF INC/IL | 991,433 | 22,347,000 | 8.89% | ||
| 4 | BlackRock Fund Advisors | 803,980 | 18,122,000 | 7.21% | ||
| 5 | VANGUARD GROUP INC | 435,756 | 9,822,000 | 3.91% | ||
| 6 | Iguana Healthcare Management, LLC | 400,000 | 9,016,000 | 3.59% | ||
| 7 | WELLS FARGO & COMPANY/MN | 398,494 | 8,983,000 | 3.57% | ||
| 8 | APEX CAPITAL, LLC | 382,000 | 8,610,000 | 3.42% | ||
| 9 | DISCIPLINED GROWTH INVESTORS INC /MN | 308,600 | 6,956,000 | 2.77% | ||
| 10 | FRANKLIN RESOURCES INC | 293,900 | 6,625,000 | 2.63% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 260,839 | 5,879,000 | 2.34% | ||
| 12 | Visium Asset Management, LP | 238,289 | 5,371,000 | 2.14% | ||
| 13 | STATE STREET CORP | 222,314 | 5,013,000 | 1.99% | ||
| 14 | Cannell & Co. | 210,403 | 4,742,000 | 1.89% | ||
| 15 | NORTHERN TRUST CORP | 199,874 | 4,505,000 | 1.79% | ||
| 16 | PRIMECAP MANAGEMENT CO/CA/ | 191,800 | 4,323,000 | 1.72% | ||
| 17 | EVENTIDE ASSET MANAGEMENT, LLC | 190,000 | 4,283,000 | 1.70% | ||
| 18 | NORGES BANK | 182,357 | 4,110,000 | 1.63% | ||
| 19 | BALYASNY ASSET MANAGEMENT L.P. | 175,895 | 3,965,000 | 1.58% | ||
| 20 | Alyeska Investment Group, L.P. | 159,198 | 3,588,000 | 1.43% | ||
| 21 | MORGAN STANLEY | 150,262 | 3,387,000 | 1.35% | ||
| 22 | BANK OF AMERICA CORP /DE/ | 140,145 | 3,159,000 | 1.26% | ||
| 23 | JPMORGAN CHASE & CO | 139,178 | 3,137,000 | 1.25% | ||
| 24 | Candriam S.C.A. | 125,700 | 2,833,000 | 1.13% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 102,162 | 2,302,000 | 0.92% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 90,439 | 2,038,000 | 0.81% | ||
| 27 | JENNISON ASSOCIATES LLC | 89,546 | 2,018,000 | 0.80% | ||
| 28 | CREDIT SUISSE AG/ | 79,723 | 1,797,000 | 0.71% | ||
| 29 | NJ State Employees Deferred Compensation Plan | 70,000 | 1,578,000 | 0.63% | ||
| 30 | Bank of New York Mellon Corp | 64,556 | 1,456,000 | 0.58% | ||
| 31 | QS Investors, LLC | 64,307 | 1,449,000 | 0.58% | ||
| 32 | BlackRock Investment Management, LLC | 59,155 | 1,333,000 | 0.53% | ||
| 33 | Birchview Capital, LP | 58,689 | 1,323,000 | 0.53% | ||
| 34 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 57,250 | 1,290,000 | 0.51% | ||
| 35 | GOLDMAN SACHS GROUP INC | 49,400 | 1,113,000 | 0.44% | Put | |
| 36 | GOLDMAN SACHS GROUP INC | 49,400 | 1,113,000 | 0.44% | Call | |
| 37 | BRAVE ASSET MANAGEMENT INC | 46,550 | 1,049,000 | 0.42% | ||
| 38 | HAMILTON LANE ADVISORS LLC | 44,376 | 1,000,000 | 0.40% | ||
| 39 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 41,519 | 936,000 | 0.37% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 41,200 | 929,000 | 0.37% | Put | |
| 41 | ALPS ADVISORS INC | 39,663 | 894,000 | 0.36% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 38,900 | 877,000 | 0.35% | Call | |
| 43 | PUTNAM INVESTMENTS LLC | 38,070 | 858,000 | 0.34% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 35,757 | 806,000 | 0.32% | ||
| 45 | Nationwide Fund Advisors | 34,684 | 782,000 | 0.31% | ||
| 46 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 31,389 | 708,000 | 0.28% | ||
| 47 | Nuveen Asset Management, LLC | 30,820 | 695,000 | 0.28% | ||
| 48 | DEUTSCHE BANK AG\ | 30,155 | 678,000 | 0.27% | ||
| 49 | GLENMEDE TRUST CO NA | 28,700 | 646,000 | 0.26% | ||
| 50 | ProShare Advisors LLC | 26,677 | 601,000 | 0.24% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
