| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | SECTORAL ASSET MANAGEMENT INC | 1,392,485 | 32,445,000 | 21.07% | ||
| 2 | FMR LLC | 852,366 | 19,860,000 | 12.90% | ||
| 3 | BVF INC/IL | 825,647 | 19,238,000 | 12.49% | ||
| 4 | BlackRock Fund Advisors | 660,957 | 15,400,000 | 10.00% | ||
| 5 | PRIMECAP MANAGEMENT CO/CA/ | 266,400 | 6,207,000 | 4.03% | ||
| 6 | FRANKLIN RESOURCES INC | 257,900 | 6,009,000 | 3.90% | ||
| 7 | COLUMBUS CIRCLE INVESTORS | 253,348 | 5,903,000 | 3.83% | ||
| 8 | Alyeska Investment Group, L.P. | 250,434 | 5,835,000 | 3.79% | ||
| 9 | VANGUARD GROUP INC | 176,813 | 4,120,000 | 2.68% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 174,683 | 4,070,000 | 2.64% | ||
| 11 | STATE STREET CORP | 162,574 | 3,790,000 | 2.46% | ||
| 12 | PICTET ASSET MANAGEMENT LTD | 93,700 | 2,183,000 | 1.42% | ||
| 13 | BANK OF AMERICA CORP /DE/ | 93,543 | 2,180,000 | 1.42% | ||
| 14 | DEUTSCHE BANK AG\ | 81,113 | 1,888,000 | 1.23% | ||
| 15 | Visium Asset Management, LP | 75,001 | 1,748,000 | 1.14% | ||
| 16 | SPHERA FUNDS MANAGEMENT LTD. | 75,000 | 1,748,000 | 1.14% | ||
| 17 | TIAA CREF INVESTMENT MANAGEMENT LLC | 72,261 | 1,684,000 | 1.09% | ||
| 18 | QS BATTERYMARCH FINANCIAL MANAGEMENT, INC | 66,800 | 1,557,000 | 1.01% | ||
| 19 | NORTHERN TRUST CORP | 64,111 | 1,494,000 | 0.97% | ||
| 20 | RENAISSANCE TECHNOLOGIES LLC | 59,200 | 1,379,000 | 0.90% | ||
| 21 | EVENTIDE ASSET MANAGEMENT, LLC | 52,800 | 1,230,000 | 0.80% | ||
| 22 | Bank of New York Mellon Corp | 52,719 | 1,228,000 | 0.80% | ||
| 23 | PRICE T ROWE ASSOCIATES INC /MD/ | 52,036 | 1,212,000 | 0.79% | ||
| 24 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 43,150 | 1,005,000 | 0.65% | ||
| 25 | Invesco Ltd. | 38,317 | 892,000 | 0.58% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 36,681 | 854,000 | 0.55% | ||
| 27 | BlackRock Investment Management, LLC | 36,105 | 841,000 | 0.55% | ||
| 28 | GLENMEDE TRUST CO NA | 28,700 | 668,000 | 0.43% | ||
| 29 | CREDIT SUISSE AG/ | 26,286 | 612,000 | 0.40% | ||
| 30 | ProShare Advisors LLC | 24,100 | 562,000 | 0.36% | ||
| 31 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 23,100 | 538,000 | 0.35% | ||
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 22,765 | 531,000 | 0.34% | ||
| 33 | JPMORGAN CHASE & CO | 22,714 | 529,000 | 0.34% | ||
| 34 | TEACHERS ADVISORS, LLC | 17,613 | 410,000 | 0.27% | ||
| 35 | BANK OF MONTREAL /CAN/ | 13,120 | 306,000 | 0.20% | ||
| 36 | JANE STREET GROUP, LLC | 12,820 | 299,000 | 0.19% | ||
| 37 | MILLENNIUM MANAGEMENT LLC | 11,400 | 266,000 | 0.17% | ||
| 38 | RUSSELL FRANK CO/ | 11,800 | 263,000 | 0.17% | ||
| 39 | BLACKROCK ADVISORS LLC | 11,098 | 259,000 | 0.17% | ||
| 40 | AMERICAN INTERNATIONAL GROUP, INC. | 11,077 | 258,095 | 0.17% | ||
| 41 | METROPOLITAN LIFE INSURANCE CO/NY | 10,270 | 239,000 | 0.16% | ||
| 42 | RHUMBLINE ADVISERS | 9,930 | 231,000 | 0.15% | ||
| 43 | Nationwide Fund Advisors | 9,611 | 224,000 | 0.15% | ||
| 44 | CITIGROUP INC | 9,035 | 211,000 | 0.14% | ||
| 45 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 8,813 | 205,000 | 0.13% | ||
| 46 | VOYA INVESTMENT MANAGEMENT LLC | 8,652 | 202,000 | 0.13% | ||
| 47 | Swiss National Bank | 7,500 | 175,000 | 0.11% | ||
| 48 | BARCLAYS PLC | 7,149 | 165,000 | 0.11% | ||
| 49 | ALLIANCEBERNSTEIN L.P. | 6,500 | 151,000 | 0.10% | ||
| 50 | BlackRock Group LTD | 6,381 | 149,000 | 0.10% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
