| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADAMS STREET PARTNERS LLC | 1,663,650 | 42,888,000 | 16.64% | ||
| 2 | SECTORAL ASSET MANAGEMENT INC | 1,533,578 | 39,536,000 | 15.34% | ||
| 3 | BVF INC/IL | 1,284,115 | 33,104,000 | 12.84% | ||
| 4 | FMR LLC | 852,366 | 21,974,000 | 8.53% | ||
| 5 | BlackRock Fund Advisors | 727,381 | 18,752,000 | 7.28% | ||
| 6 | VANGUARD GROUP INC | 362,810 | 9,353,000 | 3.63% | ||
| 7 | APEX CAPITAL, LLC | 325,000 | 8,379,000 | 3.25% | ||
| 8 | FRANKLIN RESOURCES INC | 249,300 | 6,427,000 | 2.49% | ||
| 9 | PRIMECAP MANAGEMENT CO/CA/ | 206,293 | 5,318,000 | 2.06% | ||
| 10 | STATE STREET CORP | 187,890 | 4,843,000 | 1.88% | ||
| 11 | NORGES BANK | 182,357 | 4,701,000 | 1.82% | ||
| 12 | Alyeska Investment Group, L.P. | 159,551 | 4,113,000 | 1.60% | ||
| 13 | IRONBRIDGE CAPITAL MANAGEMENT LP | 139,840 | 3,605,000 | 1.40% | ||
| 14 | NORTHERN TRUST CORP | 134,148 | 3,458,000 | 1.34% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 128,220 | 3,306,000 | 1.28% | ||
| 16 | Candriam S.C.A. | 120,000 | 3,094,000 | 1.20% | ||
| 17 | MORGAN STANLEY | 102,683 | 2,646,000 | 1.03% | ||
| 18 | PICTET ASSET MANAGEMENT LTD | 102,700 | 2,463,000 | 0.96% | ||
| 19 | BANK OF AMERICA CORP /DE/ | 94,217 | 2,429,000 | 0.94% | ||
| 20 | EVENTIDE ASSET MANAGEMENT, LLC | 85,100 | 2,194,000 | 0.85% | ||
| 21 | JPMORGAN CHASE & CO | 83,247 | 2,146,000 | 0.83% | ||
| 22 | CREDIT SUISSE AG/ | 81,791 | 2,107,000 | 0.82% | ||
| 23 | TIAA CREF INVESTMENT MANAGEMENT LLC | 79,941 | 2,061,000 | 0.80% | ||
| 24 | GEODE CAPITAL MANAGEMENT, LLC | 71,174 | 1,834,000 | 0.71% | ||
| 25 | AMERICAN CENTURY COMPANIES INC | 64,154 | 1,654,000 | 0.64% | ||
| 26 | QS Investors, LLC | 56,300 | 1,452,000 | 0.56% | ||
| 27 | Bank of New York Mellon Corp | 55,360 | 1,427,000 | 0.55% | ||
| 28 | Mitsubishi UFJ Asset Management Co., Ltd. | 54,600 | 1,408,000 | 0.55% | ||
| 29 | SMITH ASSET MANAGEMENT GROUP LP | 48,790 | 1,258,000 | 0.49% | ||
| 30 | Cannell & Co. | 46,654 | 1,203,000 | 0.47% | ||
| 31 | Birchview Capital, LP | 44,689 | 1,152,000 | 0.45% | ||
| 32 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 43,350 | 1,118,000 | 0.43% | ||
| 33 | DEUTSCHE BANK AG\ | 42,756 | 1,100,000 | 0.43% | ||
| 34 | PUTNAM INVESTMENTS LLC | 38,079 | 982,000 | 0.38% | ||
| 35 | BlackRock Investment Management, LLC | 36,936 | 952,000 | 0.37% | ||
| 36 | HAMILTON LANE ADVISORS LLC | 33,845 | 873,000 | 0.34% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 31,404 | 810,000 | 0.31% | ||
| 38 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 31,078 | 802,000 | 0.31% | ||
| 39 | GLENMEDE TRUST CO NA | 28,700 | 739,000 | 0.29% | ||
| 40 | STRS OHIO | 27,700 | 714,000 | 0.28% | ||
| 41 | ProShare Advisors LLC | 26,478 | 683,000 | 0.27% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 24,700 | 637,000 | 0.25% | Put | |
| 43 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 23,032 | 594,000 | 0.23% | ||
| 44 | Nuveen Asset Management, LLC | 22,078 | 569,000 | 0.22% | ||
| 45 | BRAVE ASSET MANAGEMENT INC | 21,150 | 545,000 | 0.21% | ||
| 46 | BANK OF MONTREAL /CAN/ | 20,095 | 518,000 | 0.20% | ||
| 47 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 18,300 | 472,000 | 0.18% | Call | |
| 48 | TEACHERS ADVISORS, LLC | 17,613 | 454,000 | 0.18% | ||
| 49 | Sterling Capital Management LLC | 17,508 | 451,000 | 0.17% | ||
| 50 | Spark Investment Management LLC | 17,000 | 437,000 | 0.17% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
