| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BVF INC/IL | 1,812,005 | 20,711,000 | 11.37% | ||
| 2 | ADAMS STREET PARTNERS LLC | 1,839,730 | 19,617,000 | 10.77% | ||
| 3 | PRIMECAP MANAGEMENT CO/CA/ | 1,302,700 | 14,890,000 | 8.18% | ||
| 4 | BlackRock Fund Advisors | 1,072,171 | 12,255,000 | 6.73% | ||
| 5 | FRANKLIN RESOURCES INC | 993,900 | 11,360,000 | 6.24% | ||
| 6 | FMR LLC | 911,303 | 10,416,000 | 5.72% | ||
| 7 | Alyeska Investment Group, L.P. | 871,302 | 9,959,000 | 5.47% | ||
| 8 | VANGUARD GROUP INC | 811,969 | 9,281,000 | 5.10% | ||
| 9 | Iguana Healthcare Management, LLC | 725,000 | 8,287,000 | 4.55% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 651,473 | 7,446,000 | 4.09% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 366,418 | 4,188,000 | 2.30% | ||
| 12 | DISCIPLINED GROWTH INVESTORS INC /MN | 300,925 | 3,440,000 | 1.89% | ||
| 13 | STATE STREET CORP | 295,100 | 3,373,000 | 1.85% | ||
| 14 | Cannell & Co. | 289,528 | 3,309,000 | 1.82% | ||
| 15 | EcoR1 Capital, LLC | 265,784 | 3,038,000 | 1.67% | ||
| 16 | NORTHERN TRUST CORP | 256,933 | 2,937,000 | 1.61% | ||
| 17 | RENAISSANCE TECHNOLOGIES LLC | 251,600 | 2,876,000 | 1.58% | ||
| 18 | First Eagle Investment Management, LLC | 230,400 | 2,633,000 | 1.45% | ||
| 19 | EVENTIDE ASSET MANAGEMENT, LLC | 190,000 | 2,172,000 | 1.19% | ||
| 20 | NORGES BANK | 182,357 | 1,991,000 | 1.09% | ||
| 21 | Candriam S.C.A. | 167,000 | 1,909,000 | 1.05% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 138,506 | 1,583,000 | 0.87% | ||
| 23 | BANK OF AMERICA CORP /DE/ | 134,904 | 1,542,000 | 0.85% | ||
| 24 | Bank of New York Mellon Corp | 102,347 | 1,170,000 | 0.64% | ||
| 25 | TURNER INVESTMENTS LLC | 95,743 | 1,094,000 | 0.60% | ||
| 26 | CREDIT SUISSE AG/ | 91,821 | 1,050,000 | 0.58% | ||
| 27 | DEUTSCHE BANK AG\ | 91,034 | 1,039,000 | 0.57% | ||
| 28 | MORGAN STANLEY | 88,516 | 1,011,000 | 0.56% | ||
| 29 | BlackRock Investment Management, LLC | 85,924 | 982,000 | 0.54% | ||
| 30 | Avoro Capital Advisors LLC | 85,000 | 972,000 | 0.53% | ||
| 31 | BARCLAYS PLC | 84,595 | 966,000 | 0.53% | ||
| 32 | Granite Point Capital Management, L.P. | 79,650 | 910,000 | 0.50% | ||
| 33 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 73,224 | 837,000 | 0.46% | ||
| 34 | Birchview Capital, LP | 70,689 | 808,000 | 0.44% | ||
| 35 | NJ State Employees Deferred Compensation Plan | 70,000 | 800,000 | 0.44% | ||
| 36 | QS Investors, LLC | 64,307 | 735,000 | 0.40% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 57,700 | 660,000 | 0.36% | Call | |
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 57,286 | 655,000 | 0.36% | ||
| 39 | BARCLAYS PLC | 50,000 | 572,000 | 0.31% | Call | |
| 40 | WELLS FARGO & COMPANY/MN | 49,536 | 566,000 | 0.31% | ||
| 41 | ALPS ADVISORS INC | 45,747 | 523,000 | 0.29% | ||
| 42 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 44,933 | 514,000 | 0.28% | ||
| 43 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 43,118 | 493,000 | 0.27% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 40,200 | 459,000 | 0.25% | Put | |
| 45 | GOLDMAN SACHS GROUP INC | 31,486 | 360,000 | 0.20% | ||
| 46 | Randolph Co Inc | 30,150 | 345,000 | 0.19% | ||
| 47 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 28,600 | 327,000 | 0.18% | ||
| 48 | TEACHERS ADVISORS, LLC | 27,462 | 314,000 | 0.17% | ||
| 49 | Swiss National Bank | 27,200 | 311,000 | 0.17% | ||
| 50 | ProShare Advisors LLC | 25,395 | 290,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
