| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADAMS STREET PARTNERS LLC | 1,663,650 | 27,600,000 | 14.75% | ||
| 2 | BVF INC/IL | 1,376,113 | 22,830,000 | 12.20% | ||
| 3 | FMR LLC | 893,664 | 14,826,000 | 7.92% | ||
| 4 | BlackRock Fund Advisors | 875,028 | 14,517,000 | 7.76% | ||
| 5 | ALPS ADVISORS INC | 46,986 | 7,795,000 | 4.17% | ||
| 6 | VANGUARD GROUP INC | 430,647 | 7,145,000 | 3.82% | ||
| 7 | APEX CAPITAL, LLC | 400,000 | 6,636,000 | 3.55% | ||
| 8 | WELLS FARGO & COMPANY/MN | 327,552 | 5,435,000 | 2.90% | ||
| 9 | DISCIPLINED GROWTH INVESTORS INC /MN | 310,150 | 5,145,000 | 2.75% | ||
| 10 | FRANKLIN RESOURCES INC | 279,400 | 4,635,000 | 2.48% | ||
| 11 | BlackRock Institutional Trust Company, N.A. | 224,284 | 3,721,000 | 1.99% | ||
| 12 | Cannell & Co. | 210,403 | 3,491,000 | 1.87% | ||
| 13 | Alyeska Investment Group, L.P. | 206,483 | 3,426,000 | 1.83% | ||
| 14 | STATE STREET CORP | 196,158 | 3,256,000 | 1.74% | ||
| 15 | PRIMECAP MANAGEMENT CO/CA/ | 190,800 | 3,165,000 | 1.69% | ||
| 16 | NORTHERN TRUST CORP | 190,664 | 3,163,000 | 1.69% | ||
| 17 | IRONBRIDGE CAPITAL MANAGEMENT LP | 182,410 | 3,026,000 | 1.62% | ||
| 18 | NORGES BANK | 182,357 | 3,025,000 | 1.62% | ||
| 19 | EVENTIDE ASSET MANAGEMENT, LLC | 146,900 | 2,437,000 | 1.30% | ||
| 20 | BANK OF AMERICA CORP /DE/ | 131,840 | 2,186,000 | 1.17% | ||
| 21 | Iguana Healthcare Management, LLC | 125,000 | 2,074,000 | 1.11% | ||
| 22 | MILLENNIUM MANAGEMENT LLC | 120,000 | 1,991,000 | 1.06% | ||
| 23 | MORGAN STANLEY | 110,084 | 1,827,000 | 0.98% | ||
| 24 | SECTORAL ASSET MANAGEMENT INC | 109,211 | 1,812,000 | 0.97% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 91,317 | 1,514,000 | 0.81% | ||
| 26 | Candriam S.C.A. | 90,700 | 1,505,000 | 0.80% | ||
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 90,439 | 1,500,000 | 0.80% | ||
| 28 | PRUDENTIAL FINANCIAL INC | 89,811 | 1,490,000 | 0.80% | ||
| 29 | TFS CAPITAL LLC | 82,843 | 1,374,000 | 0.73% | ||
| 30 | CREDIT SUISSE AG/ | 82,423 | 1,368,000 | 0.73% | ||
| 31 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 79,000 | 1,311,000 | 0.70% | Put | |
| 32 | Visium Asset Management, LP | 75,100 | 1,246,000 | 0.67% | ||
| 33 | RENAISSANCE TECHNOLOGIES LLC | 67,700 | 1,123,000 | 0.60% | ||
| 34 | QS Investors, LLC | 66,070 | 1,096,000 | 0.59% | ||
| 35 | Bank of New York Mellon Corp | 64,183 | 1,065,000 | 0.57% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 59,600 | 989,000 | 0.53% | Call | |
| 37 | Birchview Capital, LP | 58,689 | 974,000 | 0.52% | ||
| 38 | BlackRock Investment Management, LLC | 58,689 | 974,000 | 0.52% | ||
| 39 | DEUTSCHE BANK AG\ | 58,475 | 969,000 | 0.52% | ||
| 40 | GOLDMAN SACHS GROUP INC | 47,200 | 783,000 | 0.42% | Put | |
| 41 | GOLDMAN SACHS GROUP INC | 47,200 | 783,000 | 0.42% | Call | |
| 42 | BRAVE ASSET MANAGEMENT INC | 46,650 | 774,000 | 0.41% | ||
| 43 | HAMILTON LANE ADVISORS LLC | 43,965 | 729,000 | 0.39% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 40,609 | 674,000 | 0.36% | ||
| 45 | PUTNAM INVESTMENTS LLC | 38,883 | 645,000 | 0.34% | ||
| 46 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 35,850 | 595,000 | 0.32% | ||
| 47 | Nationwide Fund Advisors | 34,678 | 575,000 | 0.31% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 30,789 | 511,000 | 0.27% | ||
| 49 | Nuveen Asset Management, LLC | 29,897 | 496,000 | 0.27% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 29,382 | 487,000 | 0.26% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
