| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | SECTORAL ASSET MANAGEMENT INC | 1,598,293 | 34,779,000 | 19.42% | ||
| 2 | BVF INC/IL | 1,374,815 | 29,916,000 | 16.71% | ||
| 3 | FMR LLC | 852,366 | 18,547,000 | 10.36% | ||
| 4 | BlackRock Fund Advisors | 707,591 | 15,397,000 | 8.60% | ||
| 5 | APEX CAPITAL, LLC | 345,100 | 7,509,000 | 4.19% | ||
| 6 | VANGUARD GROUP INC | 281,443 | 6,124,000 | 3.42% | ||
| 7 | Alyeska Investment Group, L.P. | 252,658 | 5,498,000 | 3.07% | ||
| 8 | FRANKLIN RESOURCES INC | 249,300 | 5,425,000 | 3.03% | ||
| 9 | PRIMECAP MANAGEMENT CO/CA/ | 218,400 | 4,752,000 | 2.65% | ||
| 10 | STATE STREET CORP | 191,404 | 4,162,000 | 2.32% | ||
| 11 | NORGES BANK | 182,357 | 3,968,000 | 2.22% | ||
| 12 | EcoR1 Capital, LLC | 157,038 | 3,417,000 | 1.91% | ||
| 13 | IRONBRIDGE CAPITAL MANAGEMENT LP | 147,560 | 3,211,000 | 1.79% | ||
| 14 | NORTHERN TRUST CORP | 128,251 | 2,791,000 | 1.56% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 124,963 | 2,719,000 | 1.52% | ||
| 16 | DEUTSCHE BANK AG\ | 97,951 | 2,128,000 | 1.19% | ||
| 17 | PICTET ASSET MANAGEMENT LTD | 96,700 | 2,104,000 | 1.17% | ||
| 18 | MORGAN STANLEY | 93,809 | 2,041,000 | 1.14% | ||
| 19 | BANK OF AMERICA CORP /DE/ | 93,126 | 2,026,000 | 1.13% | ||
| 20 | Candriam S.C.A. | 90,000 | 1,958,000 | 1.09% | ||
| 21 | TIAA CREF INVESTMENT MANAGEMENT LLC | 72,701 | 1,582,000 | 0.88% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 69,027 | 1,502,000 | 0.84% | ||
| 23 | Bank of New York Mellon Corp | 65,111 | 1,418,000 | 0.79% | ||
| 24 | QS Investors, LLC | 56,300 | 1,226,000 | 0.68% | ||
| 25 | AMERICAN CENTURY COMPANIES INC | 56,339 | 1,226,000 | 0.68% | ||
| 26 | EVENTIDE ASSET MANAGEMENT, LLC | 52,800 | 1,149,000 | 0.64% | ||
| 27 | PRICE T ROWE ASSOCIATES INC /MD/ | 45,500 | 990,000 | 0.55% | ||
| 28 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 43,350 | 943,000 | 0.53% | ||
| 29 | BlackRock Investment Management, LLC | 36,544 | 795,000 | 0.44% | ||
| 30 | STRS OHIO | 33,600 | 731,000 | 0.41% | ||
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 29,570 | 644,000 | 0.36% | ||
| 32 | GLENMEDE TRUST CO NA | 28,700 | 624,000 | 0.35% | ||
| 33 | BLACKROCK ADVISORS LLC | 25,180 | 548,000 | 0.31% | ||
| 34 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 23,332 | 508,000 | 0.28% | ||
| 35 | ProShare Advisors LLC | 22,473 | 489,000 | 0.27% | ||
| 36 | AlpInvest Partners B.V. | 22,450 | 489,000 | 0.27% | ||
| 37 | Birchview Capital, LP | 22,489 | 489,000 | 0.27% | ||
| 38 | CREDIT SUISSE AG/ | 20,746 | 451,000 | 0.25% | ||
| 39 | RENAISSANCE TECHNOLOGIES LLC | 20,675 | 450,000 | 0.25% | ||
| 40 | CITIGROUP INC | 19,959 | 435,000 | 0.24% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 18,668 | 406,000 | 0.23% | ||
| 42 | TEACHERS ADVISORS, LLC | 17,613 | 383,000 | 0.21% | ||
| 43 | Spark Investment Management LLC | 17,600 | 382,000 | 0.21% | ||
| 44 | BRAVE ASSET MANAGEMENT INC | 17,350 | 378,000 | 0.21% | ||
| 45 | BANK OF MONTREAL /CAN/ | 15,191 | 330,000 | 0.18% | ||
| 46 | AQR CAPITAL MANAGEMENT LLC | 12,100 | 263,000 | 0.15% | ||
| 47 | METROPOLITAN LIFE INSURANCE CO/NY | 10,310 | 224,000 | 0.13% | ||
| 48 | RHUMBLINE ADVISERS | 10,230 | 223,000 | 0.12% | ||
| 49 | AMERICAN INTERNATIONAL GROUP, INC. | 10,082 | 219,384 | 0.12% | ||
| 50 | Nationwide Fund Advisors | 9,590 | 209,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
