| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | SECTORAL ASSET MANAGEMENT INC | 1,694,517 | 32,077,000 | 22.52% | ||
| 2 | BVF INC/IL | 1,287,847 | 24,379,000 | 17.12% | ||
| 3 | FMR LLC | 852,366 | 16,135,000 | 11.33% | ||
| 4 | BlackRock Fund Advisors | 665,846 | 12,604,000 | 8.85% | ||
| 5 | Alyeska Investment Group, L.P. | 302,915 | 5,734,000 | 4.03% | ||
| 6 | FRANKLIN RESOURCES INC | 249,300 | 4,719,000 | 3.31% | ||
| 7 | VANGUARD GROUP INC | 240,706 | 4,557,000 | 3.20% | ||
| 8 | PRIMECAP MANAGEMENT CO/CA/ | 218,400 | 4,134,000 | 2.90% | ||
| 9 | STATE STREET CORP | 178,565 | 3,380,000 | 2.37% | ||
| 10 | NORTHERN TRUST CORP | 134,311 | 2,542,000 | 1.78% | ||
| 11 | PRICE T ROWE ASSOCIATES INC /MD/ | 127,753 | 2,418,000 | 1.70% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 127,515 | 2,414,000 | 1.70% | ||
| 13 | DEUTSCHE BANK AG\ | 100,889 | 1,908,000 | 1.34% | ||
| 14 | SPHERA FUNDS MANAGEMENT LTD. | 97,100 | 1,838,000 | 1.29% | ||
| 15 | PICTET ASSET MANAGEMENT LTD | 96,700 | 1,830,000 | 1.28% | ||
| 16 | BANK OF AMERICA CORP /DE/ | 93,301 | 1,766,000 | 1.24% | ||
| 17 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 82,100 | 1,554,000 | 1.09% | Call | |
| 18 | Visium Asset Management, LP | 75,001 | 1,420,000 | 1.00% | ||
| 19 | MORGAN STANLEY | 72,475 | 1,372,000 | 0.96% | ||
| 20 | TIAA CREF INVESTMENT MANAGEMENT LLC | 65,228 | 1,235,000 | 0.87% | ||
| 21 | Bank of New York Mellon Corp | 62,141 | 1,177,000 | 0.83% | ||
| 22 | QS BATTERYMARCH FINANCIAL MANAGEMENT, INC | 61,200 | 1,159,000 | 0.81% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 61,112 | 1,156,000 | 0.81% | ||
| 24 | EVENTIDE ASSET MANAGEMENT, LLC | 52,800 | 1,000,000 | 0.70% | ||
| 25 | AMERICAN CENTURY COMPANIES INC | 47,496 | 899,000 | 0.63% | ||
| 26 | JPMORGAN CHASE & CO | 43,785 | 829,000 | 0.58% | ||
| 27 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 42,350 | 802,000 | 0.56% | ||
| 28 | RENAISSANCE TECHNOLOGIES LLC | 40,110 | 759,000 | 0.53% | ||
| 29 | BlackRock Investment Management, LLC | 36,960 | 700,000 | 0.49% | ||
| 30 | STRS OHIO | 31,347 | 593,000 | 0.42% | ||
| 31 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 28,777 | 545,000 | 0.38% | ||
| 32 | GLENMEDE TRUST CO NA | 28,700 | 543,000 | 0.38% | ||
| 33 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 23,232 | 440,000 | 0.31% | ||
| 34 | ProShare Advisors LLC | 20,359 | 385,000 | 0.27% | ||
| 35 | TEACHERS ADVISORS, LLC | 17,613 | 333,000 | 0.23% | ||
| 36 | MILLENNIUM MANAGEMENT LLC | 13,001 | 246,000 | 0.17% | ||
| 37 | CREDIT SUISSE AG/ | 12,924 | 244,000 | 0.17% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 12,000 | 227,000 | 0.16% | Put | |
| 39 | Airain ltd | 11,208 | 212,000 | 0.15% | ||
| 40 | BANK OF MONTREAL /CAN/ | 11,000 | 208,000 | 0.15% | ||
| 41 | AMERICAN INTERNATIONAL GROUP, INC. | 10,932 | 206,943 | 0.15% | ||
| 42 | METROPOLITAN LIFE INSURANCE CO/NY | 10,310 | 195,000 | 0.14% | ||
| 43 | COWEN INC. | 10,000 | 189,000 | 0.13% | Call | |
| 44 | Nationwide Fund Advisors | 9,724 | 184,000 | 0.13% | ||
| 45 | CITIGROUP INC | 9,289 | 176,000 | 0.12% | ||
| 46 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 8,933 | 169,000 | 0.12% | ||
| 47 | Swiss National Bank | 7,500 | 142,000 | 0.10% | ||
| 48 | ALLIANCEBERNSTEIN L.P. | 6,600 | 125,000 | 0.09% | ||
| 49 | BLACKROCK ADVISORS LLC | 5,256 | 99,000 | 0.07% | ||
| 50 | BRAVE ASSET MANAGEMENT INC | 5,250 | 99,000 | 0.07% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
