| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | ADAMS STREET PARTNERS LLC | 1,839,730 | 22,647,000 | 15.98% | ||
| 2 | BVF INC/IL | 1,339,336 | 16,487,000 | 11.64% | ||
| 3 | FMR LLC | 911,303 | 11,218,000 | 7.92% | ||
| 4 | BlackRock Fund Advisors | 839,388 | 10,333,000 | 7.29% | ||
| 5 | Iguana Healthcare Management, LLC | 632,200 | 7,782,000 | 5.49% | ||
| 6 | VANGUARD GROUP INC | 632,093 | 7,781,000 | 5.49% | ||
| 7 | Alyeska Investment Group, L.P. | 431,730 | 5,315,000 | 3.75% | ||
| 8 | MILLENNIUM MANAGEMENT LLC | 429,693 | 5,290,000 | 3.73% | ||
| 9 | DISCIPLINED GROWTH INVESTORS INC /MN | 305,625 | 3,762,000 | 2.65% | ||
| 10 | FRANKLIN RESOURCES INC | 293,900 | 3,618,000 | 2.55% | ||
| 11 | Cannell & Co. | 289,528 | 3,564,000 | 2.52% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 282,483 | 3,477,000 | 2.45% | ||
| 13 | STATE STREET CORP | 264,839 | 3,261,000 | 2.30% | ||
| 14 | NORTHERN TRUST CORP | 223,346 | 2,749,000 | 1.94% | ||
| 15 | PRIMECAP MANAGEMENT CO/CA/ | 215,800 | 2,656,000 | 1.87% | ||
| 16 | EVENTIDE ASSET MANAGEMENT, LLC | 190,000 | 2,339,000 | 1.65% | ||
| 17 | NORGES BANK | 182,357 | 2,245,000 | 1.58% | ||
| 18 | Candriam S.C.A. | 167,000 | 2,056,000 | 1.45% | ||
| 19 | TFS CAPITAL LLC | 138,394 | 1,704,000 | 1.20% | ||
| 20 | BANK OF AMERICA CORP /DE/ | 135,804 | 1,671,000 | 1.18% | ||
| 21 | CREDIT SUISSE AG/ | 107,529 | 1,323,000 | 0.93% | ||
| 22 | GEODE CAPITAL MANAGEMENT, LLC | 106,982 | 1,316,000 | 0.93% | ||
| 23 | BARCLAYS PLC | 101,933 | 1,254,000 | 0.88% | ||
| 24 | TURNER INVESTMENTS LLC | 93,810 | 1,155,000 | 0.82% | ||
| 25 | Granite Point Capital Management, L.P. | 91,850 | 1,131,000 | 0.80% | ||
| 26 | Bank of New York Mellon Corp | 89,819 | 1,106,000 | 0.78% | ||
| 27 | First Eagle Investment Management, LLC | 77,370 | 952,000 | 0.67% | ||
| 28 | Birchview Capital, LP | 70,689 | 870,000 | 0.61% | ||
| 29 | NJ State Employees Deferred Compensation Plan | 70,000 | 862,000 | 0.61% | ||
| 30 | QS Investors, LLC | 64,307 | 792,000 | 0.56% | ||
| 31 | BlackRock Investment Management, LLC | 62,957 | 775,000 | 0.55% | ||
| 32 | TIAA CREF INVESTMENT MANAGEMENT LLC | 55,897 | 688,000 | 0.49% | ||
| 33 | DEUTSCHE BANK AG\ | 44,360 | 544,000 | 0.38% | ||
| 34 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 42,821 | 528,000 | 0.37% | ||
| 35 | ALPS ADVISORS INC | 42,562 | 524,000 | 0.37% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 36,733 | 452,000 | 0.32% | ||
| 37 | Nationwide Fund Advisors | 33,202 | 409,000 | 0.29% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 32,600 | 401,000 | 0.28% | Put | |
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 32,100 | 395,000 | 0.28% | Call | |
| 40 | GLENMEDE TRUST CO NA | 28,700 | 353,000 | 0.25% | ||
| 41 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 28,600 | 352,000 | 0.25% | ||
| 42 | TEACHERS ADVISORS, LLC | 27,462 | 338,000 | 0.24% | ||
| 43 | GOLDMAN SACHS GROUP INC | 27,092 | 334,000 | 0.24% | ||
| 44 | MORGAN STANLEY | 25,214 | 311,000 | 0.22% | ||
| 45 | HANDELSBANKEN FONDER AB | 25,000 | 308,000 | 0.22% | ||
| 46 | ProShare Advisors LLC | 24,695 | 304,000 | 0.21% | ||
| 47 | PDT Partners, LLC | 24,500 | 302,000 | 0.21% | ||
| 48 | STRS OHIO | 24,000 | 295,000 | 0.21% | ||
| 49 | VIRTUS ETF ADVISERS LLC | 20,269 | 250,000 | 0.18% | ||
| 50 | BLACKROCK ADVISORS LLC | 18,316 | 225,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
