| 1 |
Clarus Ventures, LLC |
2,579,062 |
43,406,000 |
22.64% |
|
|
| 2 |
Invesco Ltd. |
1,383,448 |
23,283,000 |
12.14% |
|
|
| 3 |
Redmile Group, LLC |
960,820 |
16,171,000 |
8.43% |
|
|
| 4 |
PRICE T ROWE ASSOCIATES INC /MD/ |
850,800 |
14,319,000 |
7.47% |
|
|
| 5 |
LANSDOWNE PARTNERS (UK) LLP |
522,354 |
8,791,000 |
4.58% |
|
|
| 6 |
Fosun International Ltd |
467,551 |
7,869,000 |
4.10% |
|
|
| 7 |
WELLS FARGO & COMPANY/MN |
429,735 |
7,232,000 |
3.77% |
|
|
| 8 |
OppenheimerFunds, Inc. |
427,317 |
7,192,000 |
3.75% |
|
|
| 9 |
Cortina Asset Management, LLC |
414,100 |
6,969,000 |
3.63% |
|
|
| 10 |
Alyeska Investment Group, L.P. |
346,562 |
5,833,000 |
3.04% |
|
|
| 11 |
BlackRock Fund Advisors |
319,488 |
5,377,000 |
2.80% |
|
|
| 12 |
DOW CHEMICAL CO /DE/ |
275,755 |
4,641,000 |
2.42% |
|
|
| 13 |
NEXT CENTURY GROWTH INVESTORS LLC |
259,882 |
4,373,000 |
2.28% |
|
|
| 14 |
WALL STREET ASSOCIATES |
253,200 |
4,261,000 |
2.22% |
|
|
| 15 |
First Light Asset Management, LLC |
185,384 |
3,120,000 |
1.63% |
|
|
| 16 |
BLACKROCK ADVISORS LLC |
151,995 |
2,558,000 |
1.33% |
|
|
| 17 |
DRIEHAUS CAPITAL MANAGEMENT LLC |
149,468 |
2,516,000 |
1.31% |
|
|
| 18 |
AXA S.A. |
142,680 |
2,401,000 |
1.25% |
|
|
| 19 |
BlackRock Institutional Trust Company, N.A. |
138,719 |
2,335,000 |
1.22% |
|
|
| 20 |
TIVERTON ASSET MANAGEMENT LLC |
114,455 |
1,926,000 |
1.00% |
|
|
| 21 |
Nicholas Investment Partners, LP |
105,235 |
1,771,000 |
0.92% |
|
|
| 22 |
Waterstone Capital Management, L.P. |
97,439 |
1,640,000 |
0.86% |
|
|
| 23 |
STATE STREET CORP |
84,702 |
1,425,000 |
0.74% |
|
|
| 24 |
BlackRock Group LTD |
77,902 |
1,311,000 |
0.68% |
|
|
| 25 |
KORNITZER CAPITAL MANAGEMENT INC /KS |
72,188 |
1,215,000 |
0.63% |
|
|
| 26 |
DEUTSCHE BANK AG\ |
71,992 |
1,211,000 |
0.63% |
|
|
| 27 |
NORTHERN TRUST CORP |
62,117 |
1,045,000 |
0.54% |
|
|
| 28 |
BlackRock Investment Management, LLC |
57,457 |
967,000 |
0.50% |
|
|
| 29 |
Bank of New York Mellon Corp |
56,672 |
953,000 |
0.50% |
|
|
| 30 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
49,677 |
836,000 |
0.44% |
|
|
| 31 |
AMERIPRISE FINANCIAL INC |
47,945 |
807,000 |
0.42% |
|
|
| 32 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
27,857 |
469,000 |
0.24% |
|
|
| 33 |
FRIESS ASSOCIATES LLC |
24,000 |
404,000 |
0.21% |
|
|
| 34 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
23,700 |
399,000 |
0.21% |
|
|
| 35 |
VANGUARD GROUP INC |
20,940 |
353,000 |
0.18% |
|
|
| 36 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
19,100 |
322,000 |
0.17% |
|
|
| 37 |
TEACHERS ADVISORS, LLC |
18,476 |
311,000 |
0.16% |
|
|
| 38 |
CREDIT SUISSE AG/ |
16,726 |
281,000 |
0.15% |
|
|
| 39 |
GEODE CAPITAL MANAGEMENT, LLC |
12,974 |
218,000 |
0.11% |
|
|
| 40 |
TFS CAPITAL LLC |
12,372 |
208,000 |
0.11% |
|
|
| 41 |
METROPOLITAN LIFE INSURANCE CO/NY |
10,762 |
181,000 |
0.09% |
|
|
| 42 |
Polar Capital LLP |
10,389 |
175,000 |
0.09% |
|
|
| 43 |
Nationwide Fund Advisors |
9,645 |
162,000 |
0.08% |
|
|
| 44 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
8,878 |
149,000 |
0.08% |
|
|
| 45 |
AMERICAN INTERNATIONAL GROUP, INC. |
8,506 |
143,156 |
0.07% |
|
|
| 46 |
WELLCOME TRUST LTD (THE) as trustee of the WELLCOME TRUST |
4,350 |
73,000 |
0.04% |
|
|
| 47 |
UBS AG |
1,878 |
32,000 |
0.02% |
|
|
| 48 |
Tower Research Capital LLC (TRC) |
1,451 |
24,000 |
0.01% |
|
|
| 49 |
ALLIANCEBERNSTEIN L.P. |
1,200 |
20,000 |
0.01% |
|
|
| 50 |
VIRTUS CAPITAL ADVISERS, LLC |
1,109 |
19,000 |
0.01% |
|
|
