| 1 |
Clarus Ventures, LLC |
2,153,092 |
24,761,000 |
11.84% |
|
|
| 2 |
Invesco Ltd. |
1,783,754 |
20,514,000 |
9.81% |
|
|
| 3 |
New Leaf Venture Partners, L.L.C. |
1,377,497 |
15,841,000 |
7.57% |
|
|
| 4 |
Polar Capital LLP |
1,308,391 |
15,044,000 |
7.19% |
|
|
| 5 |
OppenheimerFunds, Inc. |
1,068,967 |
12,293,000 |
5.88% |
|
|
| 6 |
Redmile Group, LLC |
860,288 |
9,893,000 |
4.73% |
|
|
| 7 |
PRICE T ROWE ASSOCIATES INC /MD/ |
822,546 |
9,459,000 |
4.52% |
|
|
| 8 |
Alyeska Investment Group, L.P. |
790,866 |
9,095,000 |
4.35% |
|
|
| 9 |
LANSDOWNE PARTNERS (UK) LLP |
722,354 |
8,307,000 |
3.97% |
|
|
| 10 |
Cortina Asset Management, LLC |
692,520 |
7,964,000 |
3.81% |
|
|
| 11 |
TIVERTON ASSET MANAGEMENT LLC |
615,531 |
7,079,000 |
3.38% |
|
|
| 12 |
Grandeur Peak Global Advisors, LLC |
614,785 |
7,070,000 |
3.38% |
|
|
| 13 |
AXA S.A. |
609,879 |
7,014,000 |
3.35% |
|
|
| 14 |
BlackRock Fund Advisors |
539,859 |
6,208,000 |
2.97% |
|
|
| 15 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
519,670 |
5,976,000 |
2.86% |
|
|
| 16 |
First Light Asset Management, LLC |
500,697 |
5,758,000 |
2.75% |
|
|
| 17 |
Fosun International Ltd |
467,551 |
5,377,000 |
2.57% |
|
|
| 18 |
FIRST MANHATTAN CO. LLC. |
374,693 |
4,308,000 |
2.06% |
|
|
| 19 |
WADDELL & REED FINANCIAL INC |
250,300 |
2,878,000 |
1.38% |
|
|
| 20 |
STATE STREET CORP |
225,942 |
2,598,000 |
1.24% |
|
|
| 21 |
ACUTA CAPITAL PARTNERS, LLC |
190,100 |
2,186,000 |
1.05% |
|
|
| 22 |
WASATCH ADVISORS LP |
187,450 |
2,156,000 |
1.03% |
|
|
| 23 |
NORTHERN TRUST CORP |
185,544 |
2,134,000 |
1.02% |
|
|
| 24 |
BlackRock Institutional Trust Company, N.A. |
172,463 |
1,983,000 |
0.95% |
|
|
| 25 |
Granite Investment Partners, LLC |
85,532 |
984,000 |
0.47% |
|
|
| 26 |
KORNITZER CAPITAL MANAGEMENT INC /KS |
84,960 |
977,000 |
0.47% |
|
|
| 27 |
CASDIN CAPITAL, LLC |
75,000 |
863,000 |
0.41% |
|
|
| 28 |
C WorldWide Group Holding A/S |
70,460 |
837,000 |
0.40% |
|
|
| 29 |
BlackRock Investment Management, LLC |
72,193 |
830,000 |
0.40% |
|
|
| 30 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
64,453 |
741,000 |
0.35% |
|
|
| 31 |
Spark Investment Management LLC |
62,900 |
723,000 |
0.35% |
|
|
| 32 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
56,300 |
647,000 |
0.31% |
|
|
| 33 |
VANGUARD GROUP INC |
56,267 |
647,000 |
0.31% |
|
|
| 34 |
RENAISSANCE TECHNOLOGIES LLC |
53,900 |
620,000 |
0.30% |
|
|
| 35 |
Birchview Capital, LP |
40,303 |
463,000 |
0.22% |
|
|
| 36 |
Bank of New York Mellon Corp |
39,840 |
458,000 |
0.22% |
|
|
| 37 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
37,319 |
429,000 |
0.21% |
|
|
| 38 |
D. E. Shaw & Co., Inc. |
32,523 |
374,000 |
0.18% |
|
|
| 39 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
29,400 |
339,000 |
0.16% |
|
|
| 40 |
TEACHERS ADVISORS, LLC |
29,361 |
338,000 |
0.16% |
|
|
| 41 |
MORGAN STANLEY |
27,862 |
321,000 |
0.15% |
|
|
| 42 |
GEODE CAPITAL MANAGEMENT, LLC |
25,434 |
292,000 |
0.14% |
|
|
| 43 |
KEYBANK NATIONAL ASSOCIATION/OH |
23,185 |
267,000 |
0.13% |
|
|
| 44 |
WALL STREET ASSOCIATES |
22,800 |
262,000 |
0.13% |
|
|
| 45 |
CREDIT SUISSE AG/ |
18,608 |
214,000 |
0.10% |
|
|
| 46 |
NEW YORK STATE COMMON RETIREMENT FUND |
18,400 |
212,000 |
0.10% |
|
|
| 47 |
RHUMBLINE ADVISERS |
18,220 |
210,000 |
0.10% |
|
|
| 48 |
WELLS FARGO & COMPANY/MN |
14,695 |
169,000 |
0.08% |
|
|
| 49 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
14,492 |
166,000 |
0.08% |
|
|
| 50 |
Nationwide Fund Advisors |
13,511 |
155,000 |
0.07% |
|
|
