| 1 |
Clarus Ventures, LLC |
2,153,092 |
27,043,000 |
12.09% |
|
|
| 2 |
Invesco Ltd. |
1,783,866 |
22,405,000 |
10.02% |
|
|
| 3 |
Polar Capital LLP |
1,493,183 |
18,752,000 |
8.38% |
|
|
| 4 |
Redmile Group, LLC |
1,431,119 |
17,975,000 |
8.04% |
|
|
| 5 |
New Leaf Venture Partners, L.L.C. |
1,377,497 |
17,301,000 |
7.74% |
|
|
| 6 |
Alyeska Investment Group, L.P. |
856,878 |
10,762,000 |
4.81% |
|
|
| 7 |
PRICE T ROWE ASSOCIATES INC /MD/ |
812,927 |
10,210,000 |
4.57% |
|
|
| 8 |
First Light Asset Management, LLC |
723,882 |
9,092,000 |
4.07% |
|
|
| 9 |
Grandeur Peak Global Advisors, LLC |
673,579 |
8,460,000 |
3.78% |
|
|
| 10 |
BlackRock Fund Advisors |
617,826 |
7,760,000 |
3.47% |
|
|
| 11 |
AXA S.A. |
603,803 |
7,584,000 |
3.39% |
|
|
| 12 |
Cortina Asset Management, LLC |
592,544 |
7,442,000 |
3.33% |
|
|
| 13 |
Fosun International Ltd |
467,551 |
5,872,000 |
2.63% |
|
|
| 14 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
464,541 |
5,835,000 |
2.61% |
|
|
| 15 |
ACUTA CAPITAL PARTNERS, LLC |
407,815 |
5,122,000 |
2.29% |
|
|
| 16 |
WASATCH ADVISORS LP |
270,897 |
3,402,000 |
1.52% |
|
|
| 17 |
STATE STREET CORP |
262,259 |
3,298,000 |
1.47% |
|
|
| 18 |
TIVERTON ASSET MANAGEMENT LLC |
262,500 |
3,297,000 |
1.47% |
|
|
| 19 |
WADDELL & REED FINANCIAL INC |
250,300 |
3,144,000 |
1.41% |
|
|
| 20 |
RTW INVESTMENTS, LP |
235,900 |
2,963,000 |
1.32% |
|
|
| 21 |
NORTHERN TRUST CORP |
200,648 |
2,520,000 |
1.13% |
|
|
| 22 |
C WorldWide Group Holding A/S |
200,000 |
2,512,000 |
1.12% |
|
|
| 23 |
RENAISSANCE TECHNOLOGIES LLC |
199,200 |
2,502,000 |
1.12% |
|
|
| 24 |
BlackRock Institutional Trust Company, N.A. |
179,532 |
2,255,000 |
1.01% |
|
|
| 25 |
Endurant Capital Management LP |
111,655 |
1,402,000 |
0.63% |
|
|
| 26 |
KORNITZER CAPITAL MANAGEMENT INC /KS |
97,500 |
1,225,000 |
0.55% |
|
|
| 27 |
BlackRock Investment Management, LLC |
90,030 |
1,131,000 |
0.51% |
|
|
| 28 |
Nicholas Investment Partners, LP |
74,867 |
940,000 |
0.42% |
|
|
| 29 |
Bank of New York Mellon Corp |
69,189 |
869,000 |
0.39% |
|
|
| 30 |
Birchview Capital, LP |
67,303 |
845,000 |
0.38% |
|
|
| 31 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
66,539 |
836,000 |
0.37% |
|
|
| 32 |
VANGUARD GROUP INC |
60,217 |
756,000 |
0.34% |
|
|
| 33 |
ESSEX INVESTMENT MANAGEMENT CO LLC |
57,078 |
717,000 |
0.32% |
|
|
| 34 |
Neuberger Berman Group LLC |
56,891 |
715,000 |
0.32% |
|
|
| 35 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
47,046 |
591,000 |
0.26% |
|
|
| 36 |
KEYBANK NATIONAL ASSOCIATION/OH |
45,980 |
578,000 |
0.26% |
|
|
| 37 |
ARDSLEY ADVISORY PARTNERS LP |
40,000 |
502,000 |
0.22% |
|
|
| 38 |
Spark Investment Management LLC |
39,300 |
493,000 |
0.22% |
|
|
| 39 |
GEODE CAPITAL MANAGEMENT, LLC |
38,507 |
483,000 |
0.22% |
|
|
| 40 |
TEACHERS ADVISORS, LLC |
33,382 |
419,000 |
0.19% |
|
|
| 41 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
29,400 |
370,000 |
0.17% |
|
|
| 42 |
DEUTSCHE BANK AG\ |
29,172 |
365,000 |
0.16% |
|
|
| 43 |
D. E. Shaw & Co., Inc. |
27,702 |
348,000 |
0.16% |
|
|
| 44 |
RHUMBLINE ADVISERS |
24,780 |
311,000 |
0.14% |
|
|
| 45 |
NEW YORK STATE COMMON RETIREMENT FUND |
22,987 |
289,000 |
0.13% |
|
|
| 46 |
WALL STREET ASSOCIATES |
22,800 |
286,000 |
0.13% |
|
|
| 47 |
WELLS FARGO & COMPANY/MN |
21,195 |
266,000 |
0.12% |
|
|
| 48 |
GOLDMAN SACHS GROUP INC |
17,656 |
222,000 |
0.10% |
|
|
| 49 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
15,434 |
194,000 |
0.09% |
|
|
| 50 |
Nationwide Fund Advisors |
13,511 |
170,000 |
0.08% |
|
|
