| 1 |
Clarus Ventures, LLC |
2,153,092 |
29,067,000 |
11.68% |
|
|
| 2 |
Invesco Ltd. |
1,783,754 |
24,081,000 |
9.67% |
|
|
| 3 |
New Leaf Venture Partners, L.L.C. |
1,377,497 |
18,596,000 |
7.47% |
|
|
| 4 |
OppenheimerFunds, Inc. |
1,063,527 |
14,358,000 |
5.77% |
|
|
| 5 |
Polar Capital LLP |
1,048,618 |
14,154,000 |
5.69% |
|
|
| 6 |
Redmile Group, LLC |
1,028,132 |
13,880,000 |
5.58% |
|
|
| 7 |
Alyeska Investment Group, L.P. |
909,331 |
12,276,000 |
4.93% |
|
|
| 8 |
PRICE T ROWE ASSOCIATES INC /MD/ |
829,246 |
11,195,000 |
4.50% |
|
|
| 9 |
TIVERTON ASSET MANAGEMENT LLC |
725,000 |
9,788,000 |
3.93% |
|
|
| 10 |
LANSDOWNE PARTNERS (UK) LLP |
722,354 |
9,752,000 |
3.92% |
|
|
| 11 |
Cortina Asset Management, LLC |
649,875 |
8,773,000 |
3.52% |
|
|
| 12 |
AXA S.A. |
610,680 |
8,244,000 |
3.31% |
|
|
| 13 |
BlackRock Fund Advisors |
527,481 |
7,121,000 |
2.86% |
|
|
| 14 |
First Light Asset Management, LLC |
520,755 |
7,030,000 |
2.82% |
|
|
| 15 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
519,670 |
7,016,000 |
2.82% |
|
|
| 16 |
Grandeur Peak Global Advisors, LLC |
483,910 |
6,533,000 |
2.62% |
|
|
| 17 |
Fosun International Ltd |
467,551 |
6,312,000 |
2.54% |
|
|
| 18 |
FIRST MANHATTAN CO. LLC. |
390,600 |
5,273,000 |
2.12% |
|
|
| 19 |
Tamarack Capital Management, LLC |
375,000 |
5,063,000 |
2.03% |
|
|
| 20 |
STATE STREET CORP |
217,050 |
2,929,000 |
1.18% |
|
|
| 21 |
WADDELL & REED FINANCIAL INC |
196,400 |
2,652,000 |
1.07% |
|
|
| 22 |
ACUTA CAPITAL PARTNERS, LLC |
184,746 |
2,494,000 |
1.00% |
|
|
| 23 |
NORTHERN TRUST CORP |
179,061 |
2,417,000 |
0.97% |
|
|
| 24 |
WASATCH ADVISORS LP |
177,762 |
2,400,000 |
0.96% |
|
|
| 25 |
BlackRock Institutional Trust Company, N.A. |
168,871 |
2,280,000 |
0.92% |
|
|
| 26 |
KORNITZER CAPITAL MANAGEMENT INC /KS |
127,300 |
1,719,000 |
0.69% |
|
|
| 27 |
C WorldWide Group Holding A/S |
120,460 |
1,626,000 |
0.65% |
|
|
| 28 |
Granite Investment Partners, LLC |
100,195 |
1,352,000 |
0.54% |
|
|
| 29 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
79,464 |
1,073,000 |
0.43% |
|
|
| 30 |
BlackRock Investment Management, LLC |
71,199 |
961,000 |
0.39% |
|
|
| 31 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
64,453 |
870,000 |
0.35% |
|
|
| 32 |
Spark Investment Management LLC |
55,800 |
751,000 |
0.30% |
|
|
| 33 |
VANGUARD GROUP INC |
55,221 |
746,000 |
0.30% |
|
|
| 34 |
FRIESS ASSOCIATES LLC |
48,200 |
651,000 |
0.26% |
|
|
| 35 |
Bank of New York Mellon Corp |
40,020 |
540,000 |
0.22% |
|
|
| 36 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
36,687 |
495,000 |
0.20% |
|
|
| 37 |
RENAISSANCE TECHNOLOGIES LLC |
32,800 |
443,000 |
0.18% |
|
|
| 38 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
29,400 |
397,000 |
0.16% |
|
|
| 39 |
TEACHERS ADVISORS, LLC |
29,361 |
396,000 |
0.16% |
|
|
| 40 |
GEODE CAPITAL MANAGEMENT, LLC |
26,571 |
358,000 |
0.14% |
|
|
| 41 |
KEYBANK NATIONAL ASSOCIATION/OH |
23,095 |
312,000 |
0.13% |
|
|
| 42 |
WALL STREET ASSOCIATES |
22,800 |
308,000 |
0.12% |
|
|
| 43 |
PIPER SANDLER & CO. |
22,500 |
304,000 |
0.12% |
|
|
| 44 |
NEW YORK STATE COMMON RETIREMENT FUND |
18,400 |
248,000 |
0.10% |
|
|
| 45 |
D. E. Shaw & Co., Inc. |
17,040 |
230,000 |
0.09% |
|
|
| 46 |
RHUMBLINE ADVISERS |
16,360 |
221,000 |
0.09% |
|
|
| 47 |
Birchview Capital, LP |
15,303 |
207,000 |
0.08% |
|
|
| 48 |
WELLS FARGO & COMPANY/MN |
14,908 |
201,000 |
0.08% |
|
|
| 49 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
14,492 |
196,000 |
0.08% |
|
|
| 50 |
Nationwide Fund Advisors |
12,876 |
174,000 |
0.07% |
|
|
