| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Clarus Ventures, LLC | 2,579,062 | 39,382,000 | 22.11% | ||
| 2 | Invesco Ltd. | 1,383,448 | 21,125,000 | 11.86% | ||
| 3 | Redmile Group, LLC | 1,066,415 | 16,284,000 | 9.14% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 849,900 | 12,978,000 | 7.29% | ||
| 5 | LANSDOWNE PARTNERS (UK) LLP | 522,354 | 7,976,000 | 4.48% | ||
| 6 | Cortina Asset Management, LLC | 521,609 | 7,965,000 | 4.47% | ||
| 7 | OppenheimerFunds, Inc. | 516,227 | 7,883,000 | 4.43% | ||
| 8 | TIVERTON ASSET MANAGEMENT LLC | 512,100 | 7,822,000 | 4.39% | ||
| 9 | Fosun International Ltd | 467,551 | 7,140,000 | 4.01% | ||
| 10 | WELLS FARGO & COMPANY/MN | 444,198 | 6,782,000 | 3.81% | ||
| 11 | Alyeska Investment Group, L.P. | 330,912 | 5,053,000 | 2.84% | ||
| 12 | BlackRock Fund Advisors | 306,709 | 4,683,000 | 2.63% | ||
| 13 | AXA S.A. | 256,286 | 3,913,000 | 2.20% | ||
| 14 | WALL STREET ASSOCIATES | 231,200 | 3,530,000 | 1.98% | ||
| 15 | NEXT CENTURY GROWTH INVESTORS LLC | 217,455 | 3,320,000 | 1.86% | ||
| 16 | First Light Asset Management, LLC | 189,766 | 2,898,000 | 1.63% | ||
| 17 | KORNITZER CAPITAL MANAGEMENT INC /KS | 185,898 | 2,839,000 | 1.59% | ||
| 18 | DRIEHAUS CAPITAL MANAGEMENT LLC | 146,930 | 2,244,000 | 1.26% | ||
| 19 | NORTHERN TRUST CORP | 115,674 | 1,767,000 | 0.99% | ||
| 20 | BlackRock Institutional Trust Company, N.A. | 112,503 | 1,718,000 | 0.96% | ||
| 21 | STATE STREET CORP | 97,270 | 1,486,000 | 0.83% | ||
| 22 | Waterstone Capital Management, L.P. | 86,280 | 1,317,000 | 0.74% | ||
| 23 | DEUTSCHE BANK AG\ | 59,213 | 903,000 | 0.51% | ||
| 24 | C WorldWide Group Holding A/S | 60,000 | 898,000 | 0.50% | ||
| 25 | Manatuck Hill Partners, LLC | 50,000 | 763,000 | 0.43% | ||
| 26 | TIAA CREF INVESTMENT MANAGEMENT LLC | 49,677 | 759,000 | 0.43% | ||
| 27 | AMERIPRISE FINANCIAL INC | 47,945 | 732,000 | 0.41% | ||
| 28 | Bank of New York Mellon Corp | 40,922 | 625,000 | 0.35% | ||
| 29 | BlackRock Investment Management, LLC | 37,628 | 575,000 | 0.32% | ||
| 30 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 24,036 | 367,000 | 0.21% | ||
| 31 | VANGUARD GROUP INC | 20,275 | 310,000 | 0.17% | ||
| 32 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 19,100 | 292,000 | 0.16% | ||
| 33 | TEACHERS ADVISORS, LLC | 18,476 | 282,000 | 0.16% | ||
| 34 | Whetstone Capital Advisors, LLC | 16,000 | 244,000 | 0.14% | ||
| 35 | TFS CAPITAL LLC | 15,065 | 230,000 | 0.13% | ||
| 36 | GEODE CAPITAL MANAGEMENT, LLC | 14,571 | 222,000 | 0.12% | ||
| 37 | Polar Capital LLP | 13,681 | 209,000 | 0.12% | ||
| 38 | Nationwide Fund Advisors | 9,820 | 150,000 | 0.08% | ||
| 39 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 9,054 | 139,000 | 0.08% | ||
| 40 | AMERICAN INTERNATIONAL GROUP, INC. | 8,499 | 129,780 | 0.07% | ||
| 41 | BLACKROCK ADVISORS LLC | 5,470 | 84,000 | 0.05% | ||
| 42 | UBS AG | 1,311 | 20,000 | 0.01% | ||
| 43 | BNP PARIBAS FINANCIAL MARKETS | 1,147 | 17,515 | 0.01% | ||
| 44 | PANAGORA ASSET MANAGEMENT INC | 1,065 | 16,000 | 0.01% | ||
| 45 | ALLIANCEBERNSTEIN L.P. | 600 | 9,000 | 0.01% | ||
| 46 | MORGAN STANLEY | 532 | 8,000 | 0.00% | ||
| 47 | CITIGROUP INC | 453 | 7,000 | 0.00% | ||
| 48 | BARCLAYS PLC | 427 | 6,000 | 0.00% | ||
| 49 | BANK OF AMERICA CORP /DE/ | 161 | 2,000 | 0.00% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
