| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Invesco Ltd. | 1,783,752 | 26,668,000 | 9.74% | ||
| 2 | Polar Capital LLP | 1,732,603 | 25,899,000 | 9.46% | ||
| 3 | Redmile Group, LLC | 1,701,049 | 25,431,000 | 9.29% | ||
| 4 | New Leaf Venture Partners, L.L.C. | 1,377,497 | 20,594,000 | 7.52% | ||
| 5 | Clarus Ventures, LLC | 1,159,425 | 17,333,000 | 6.33% | ||
| 6 | Alyeska Investment Group, L.P. | 868,965 | 12,991,000 | 4.74% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 810,327 | 12,114,000 | 4.42% | ||
| 8 | First Light Asset Management, LLC | 747,639 | 11,177,000 | 4.08% | ||
| 9 | BlackRock Fund Advisors | 711,194 | 10,632,000 | 3.88% | ||
| 10 | Grandeur Peak Global Advisors, LLC | 649,403 | 9,709,000 | 3.54% | ||
| 11 | AXA S.A. | 601,750 | 8,996,000 | 3.28% | ||
| 12 | Cortina Asset Management, LLC | 569,432 | 8,513,000 | 3.11% | ||
| 13 | RTW INVESTMENTS, LP | 543,287 | 8,122,000 | 2.97% | ||
| 14 | DEERFIELD MANAGEMENT COMPANY, L.P. | 529,197 | 7,911,000 | 2.89% | ||
| 15 | ACUTA CAPITAL PARTNERS, LLC | 470,834 | 7,039,000 | 2.57% | ||
| 16 | Fosun International Ltd | 467,551 | 6,990,000 | 2.55% | ||
| 17 | STATE STREET CORP | 320,599 | 4,792,000 | 1.75% | ||
| 18 | WASATCH ADVISORS LP | 315,897 | 4,723,000 | 1.72% | ||
| 19 | TIVERTON ASSET MANAGEMENT LLC | 262,500 | 3,925,000 | 1.43% | ||
| 20 | WADDELL & REED FINANCIAL INC | 222,200 | 3,322,000 | 1.21% | ||
| 21 | NORTHERN TRUST CORP | 206,681 | 3,090,000 | 1.13% | ||
| 22 | BlackRock Institutional Trust Company, N.A. | 185,629 | 2,775,000 | 1.01% | ||
| 23 | RENAISSANCE TECHNOLOGIES LLC | 183,700 | 2,746,000 | 1.00% | ||
| 24 | C WorldWide Group Holding A/S | 160,000 | 2,392,000 | 0.87% | ||
| 25 | BlackRock Investment Management, LLC | 90,607 | 1,355,000 | 0.49% | ||
| 26 | ESSEX INVESTMENT MANAGEMENT CO LLC | 90,472 | 1,353,000 | 0.49% | ||
| 27 | NEUBURGH ADVISERS LLC | 89,250 | 1,334,000 | 0.49% | ||
| 28 | KORNITZER CAPITAL MANAGEMENT INC /KS | 76,500 | 1,144,000 | 0.42% | ||
| 29 | FLINTON CAPITAL MANAGEMENT LLC | 73,500 | 1,099,000 | 0.40% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 72,555 | 1,085,000 | 0.40% | ||
| 31 | Bank of New York Mellon Corp | 70,306 | 1,051,000 | 0.38% | ||
| 32 | Nicholas Investment Partners, LP | 67,842 | 1,018,000 | 0.37% | ||
| 33 | Birchview Capital, LP | 67,303 | 1,006,000 | 0.37% | ||
| 34 | MORGAN STANLEY | 64,608 | 966,000 | 0.35% | ||
| 35 | VANGUARD GROUP INC | 64,298 | 961,000 | 0.35% | ||
| 36 | Spark Investment Management LLC | 61,200 | 914,000 | 0.33% | ||
| 37 | TYERS ASSET MANAGEMENT LLC | 57,750 | 863,000 | 0.32% | ||
| 38 | Neuberger Berman Group LLC | 55,100 | 824,000 | 0.30% | ||
| 39 | KEYBANK NATIONAL ASSOCIATION/OH | 45,980 | 687,000 | 0.25% | ||
| 40 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 45,646 | 682,000 | 0.25% | ||
| 41 | GEODE CAPITAL MANAGEMENT, LLC | 43,269 | 646,000 | 0.24% | ||
| 42 | JPMORGAN CHASE & CO | 42,850 | 641,000 | 0.23% | ||
| 43 | GLEN HARBOR CAPITAL MANAGEMENT LLC | 42,000 | 628,000 | 0.23% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 40,500 | 606,000 | 0.22% | ||
| 45 | TEACHERS ADVISORS, LLC | 39,932 | 597,000 | 0.22% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 36,308 | 543,000 | 0.20% | ||
| 47 | D. E. Shaw & Co., Inc. | 36,015 | 538,000 | 0.20% | ||
| 48 | CITIGROUP INC | 33,463 | 500,000 | 0.18% | ||
| 49 | ARDSLEY ADVISORY PARTNERS LP | 30,000 | 449,000 | 0.16% | ||
| 50 | WELLS FARGO & COMPANY/MN | 28,774 | 430,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
